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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Irs2
insulin receptor substrate 2
MGI:109334
45 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Cdkn1btm1Kin/\Cdkn1b+
\Irs2tm1Mfw/\Irs2tm1Mfw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		enlarged pancreatic islets J:96047
increased circulating glucose level J:96047
increased circulating insulin level J:96047
increased pancreatic beta cell number J:96047
\Cdkn1btm1Kin/\Cdkn1btm1Kin
\Irs2tm1Mfw/\Irs2tm1Mfw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		enlarged pancreatic islets J:96047
increased circulating glucose level J:96047
increased circulating insulin level J:96047
increased pancreatic beta cell number J:96047
\Foxo1tm1Rdp/\Foxo1tm1Rdp
\Irs1tm1Mfw/\Irs1tm1Mfw
\Irs2tm2Mfw/\Irs2tm2Mfw
\Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB 		abnormal triglyceride level J:137845
decreased circulating cholesterol level J:137845
decreased circulating free fatty acids level J:137845
decreased circulating HDL cholesterol level J:137845
decreased circulating triglyceride level J:137845
normal homeostasis/metabolism phenotype J:137845
\Foxo1tm1Whb/\Foxo1+
\Irs2tm1Mfw/\Irs2tm1Mfw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal endocrine/exocrine gland phenotype J:80826
normal homeostasis/metabolism phenotype J:80826
\Gsk3btm1Jrw/\Gsk3b+
\Irs2tm1Mfw/\Irs2tm1Mfw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal circulating glucose level J:135659
abnormal pancreatic islet cell apoptosis J:135659
normal growth/size/body region phenotype J:135659
increased circulating glucose level J:135659
increased circulating insulin level J:135659
increased pancreatic beta cell proliferation J:135659
insulin resistance J:135659
\Gsk3btm2Jrw/\Gsk3btm2Jrw
\Irs2tm1Mfw/\Irs2tm1Mfw
\Tg(Ins2-cre)23Herr/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J 		abnormal circulating glucose level J:135659
increased circulating insulin level J:135659
\Insrtm1Dac/\Insr+
\Irs2tm1Mfw/\Irs2tm1Mfw
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		abnormal glucose homeostasis J:80826
absent pancreatic beta cells J:80826
postnatal lethality J:80826
\Irs1tm1Jos/\Irs1+
\Irs2tm2Mfw/\Irs2tm2Mfw
\Tg(Ins2-cre)25Mgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal pancreatic beta cell morphology J:93415
decreased body weight J:93415
decreased circulating insulin level J:93415
hyperglycemia J:93415
\Irs1tm1Mfw/\Irs1+
\Irs2tm2Mfw/\Irs2tm2Mfw
\Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N 		impaired glucose tolerance J:156999
\Irs1tm1Mfw/\Irs1tm1Mfw
\Irs2tm2Mfw/\Irs2tm2Mfw
\Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA 		abnormal triglyceride level J:137845
decreased body size J:137845
decreased circulating cholesterol level J:137845
decreased circulating free fatty acids level J:137845
decreased circulating HDL cholesterol level J:137845
decreased circulating triglyceride level J:137845
decreased liver glycogen level J:137845
hyperglycemia J:137845
impaired glucose tolerance J:137845
increased circulating glucose level J:137845
increased circulating insulin level J:137845
increased susceptibility to autoimmune diabetes J:137845
insulin resistance J:137845
\Irs1tm1Mfw/\Irs1tm2.1Mfw
\Irs2tm2Mfw/\Irs2tm2Mfw
\Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N 		impaired glucose tolerance J:156999
increased circulating insulin level J:156999
insulin resistance J:156999
\Irs1tm1Tka/\Irs1tm1Tka
\Irs2tm1Tka/\Irs2tm1Tka
involves: C57BL/6 * CBA 		abnormal cell differentiation J:68004
decreased white adipose tissue amount J:68004
\Irs1tm2.1Mfw/\Irs1tm2.1Mfw
\Irs2tm2Mfw/\Irs2tm2Mfw
\Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N 		impaired glucose tolerance J:156999
increased circulating insulin level J:156999
\Irs1tm2Tka/\Irs1tm2Tka
\Irs2tm2Tka/\Irs2tm2Tka
\Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA 		increased susceptibility to autoimmune diabetes J:137846
insulin resistance J:137846
\Irs2tm1Mfw/\Irs2tm1Mfw
\Ptpn1tm1Bbk/\Ptpn1tm1Bbk
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal pancreatic beta cell morphology J:87249
decreased body weight J:87249
hyperglycemia J:87249
impaired glucose tolerance J:87249
increased insulin sensitivity J:87249
pancreatic islet hyperplasia J:87249
premature death J:87249
\Irs2tm1Mfw/\Irs2tm1Mfw
\Tg(Pdx1)#Mmy/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal retina layer morphology J:98107
decreased total retina thickness J:98107
retina outer nuclear layer degeneration J:98107
retina photoreceptor degeneration J:98107
\Irs2tm2Mfw/\Irs2tm2Mfw
\Irs4tm1.1Mfw/Y
\Leprtm3(cre)Mgmj/\Lepr+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal growth/size/body region phenotype J:221293
normal homeostasis/metabolism phenotype J:221293
\Irs2tm2Mfw/\Irs2tm2Mfw
\Irs4tm1.1Mfw/Y
\Tg(Nes-cre)1Kln/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal adipose tissue amount J:221293
abnormal glucose homeostasis J:221293
decreased basal metabolism J:221293
decreased oxygen consumption J:221293
hepatic steatosis J:221293
impaired glucose tolerance J:221293
increased body weight J:221293
increased brown fat cell lipid droplet size J:221293
increased circulating glucose level J:221293
increased circulating insulin level J:221293
increased circulating leptin level J:221293
increased fasting circulating glucose level J:221293
increased food intake J:221293
insulin resistance J:221293
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory