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Cdkn1btm1Kin
Targeted Allele Detail
Summary
Symbol: Cdkn1btm1Kin
Name: cyclin dependent kinase inhibitor 1B; targeted mutation 1, Kei-ichi Nakayama
MGI ID: MGI:1888790
Synonyms: p27-, p27Kip1, p27Kip1-
Gene: Cdkn1b  Location: Chr6:134897364-134902476 bp, + strand  Genetic Position: Chr6, 65.77 cM
Alliance: Cdkn1btm1Kin page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33402
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette in reverse orientation replaced a 2.5kb sequence containing exons 1 and 2. This deletes the entire coding portion of the gene. Immunoblots of whole tissue lysates of the thymus demnonstrate the absence of protein product. (J:33402)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 44 assay results
In Structures Affected by this Mutation: 19 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Cdkn1btm1Kin
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn1b Mutation:  25 strains or lines available
References
Original:  J:33402 Nakayama K, et al., Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell. 1996 May 31;85(5):707-20
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory