Irs2^tm2Tka
Targeted Allele Detail

Summary

• Symbol: Irs2^tm2Tka
• Name: insulin receptor substrate 2; targeted mutation 2, Tetsuo Noda
• MGI ID: MGI:3497742
• Synonyms: Irs2^lox
• Gene: Irs2 Location: Chr8:11034681-11058458 bp, - strand Genetic Position: Chr8, 5.35 cM
• Alliance: Irs2^tm2Tka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93416
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank the gene with loxp sites. Transient Cre excised a floxed neo that was inserted also inserted by the vector. (J:93416)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irs2 Mutation: 35 strains or lines available

References

• Original: J:93416 Kubota N, et al., Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest. 2004 Nov;114(7):917-27
• All: 9 reference(s)