Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1tm2Tka mutation
(0 available);
any
Irs1 mutation
(51 available)
Irs2tm2Tka mutation
(0 available);
any
Irs2 mutation
(35 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation
(6 available);
any
Speer6-ps1 mutation
(4 available)
|
|
|
homeostasis/metabolism
immune system
|
• mice develop diabetes
• however, over-expression of a dominant negative Foxo1 by adenoviral transfection improves diabetes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs2tm2Tka mutation
(0 available);
any
Irs2 mutation
(35 available)
Tg(Ins2-cre)25Mgn mutation
(2 available)
|
|
|
adipose tissue
|
• the mass of the epididymal fat pad is increased at 12 weeks of age
|
endocrine/exocrine glands
|
• beta cell mass is significantly reduced with or without caloric restriction at 8 and 12 weeks of age
• however at 10 days of age beta cell mass is not reduced
|
growth/size/body
|
• body weights are significantly greater than controls by 5 weeks of age
|
|
• on a regular or high fat diet mutants become obese, however pair fed mutants do not become obese
|
homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs2tm2Tka mutation
(0 available);
any
Irs2 mutation
(35 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation
(6 available);
any
Speer6-ps1 mutation
(4 available)
|
|
|