65 phenotypes from 11 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gpx4tm1.1(KOMP)Vlcg/Gpx4+ C57BL/6N-Gpx4tm1.1(KOMP)Vlcg/MbpMmucd	hydrometra	J:211773
Gpx4tm1.1(KOMP)Vlcg/Gpx4tm1.1(KOMP)Vlcg C57BL/6N-Gpx4tm1.1(KOMP)Vlcg/MbpMmucd	preweaning lethality, complete penetrance	J:211773
Gpx4tm1.1(KOMP)Vlcg/Gpx4tm1.1(KOMP)Vlcg C57BL/6N-Gpx4tm1.1(KOMP)Vlcg/Ucd	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
Gpx4tm1.1Qra/Gpx4tm1.1Qra Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL	abnormal cellular respiration	J:183246
	astrocytosis	J:183246
	cachexia	J:183246
	increased hepatocyte apoptosis	J:183246
	lethality, complete penetrance	J:183246
	lethargy	J:183246
	neurodegeneration	J:183246
Gpx4tm1Marc/Gpx4tm1Marc involves: 129P2/OlaHsd	normal reproductive system phenotype	J:100525
Gpx4tm1Prol/Gpx4+ involves: 129	no abnormal phenotype detected	J:82053
Gpx4tm1Prol/Gpx4+ involves: 129 * C57BL/6J	increased mortality induced by gamma-irradiation	J:82053
Gpx4tm1Prol/Gpx4tm1Prol involves: 129 * C57BL/6J	abnormal germ layer development	J:82053
	embryonic lethality between implantation and somite formation, complete penetrance	J:82053
	failure to gastrulate	J:82053
Gpx4tm1Ssd/Gpx4+ B6.129-Gpx4tm1Ssd	abnormal mitochondrial physiology	J:134214
	oxidative stress	J:134214
Gpx4tm1Ssd/Gpx4tm1Ssd B6.129-Gpx4tm1Ssd	embryonic lethality, complete penetrance	J:134214
Gpx4tm1Yana/Gpx4tm1Yana involves: C57BL/6 * CBA	abnormal apoptosis	J:83472
	decreased embryo size	J:83472
	embryonic lethality between somite formation and embryo turning, complete penetrance	J:83472
	failure to gastrulate	J:83472
Gpx4tm1Yana/Gpx4tm1Yana Tg(Crx-cre)1Tfur/0 Tg(Gpx4)#Yana/0 involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2	abnormal photoreceptor connecting cilium morphology	J:182776
	abnormal photoreceptor inner segment morphology	J:182776
	abnormal photoreceptor outer segment morphology	J:182776
	abnormal retina morphology	J:182776
	decreased mitochondrial DNA content	J:182776
	disorganized photoreceptor outer segment	J:182776
	retina degeneration	J:182776
	retina outer nuclear layer degeneration	J:182776
	thin retina inner nuclear layer	J:182776
Gpx4tm1Yana/Gpx4tm1Yana Tg(Gpx4)#Yana/0 involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2 * ICR	no abnormal phenotype detected	J:156326
Gpx4tm1Yana/Gpx4tm1Yana Tg(Gpx4)#Yana/0 Tg(Pgk2-cre)24Shb/0 involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2 * ICR	abnormal male germ cell morphology	J:156326
	abnormal mitochondrial physiology	J:156326
	abnormal sperm mitochondrial sheath morphology	J:156326
	abnormal sperm physiology	J:156326
	asthenozoospermia	J:156326
	decreased body weight	J:156326
	decreased male germ cell number	J:156326
	decreased testis weight	J:156326
	hairpin sperm flagellum	J:156326
	male infertility	J:156326
	oligozoospermia	J:156326
	small testis	J:156326
Gpx4tm2.1Marc/Gpx4tm2.1Marc involves: 129P2/OlaHsd * BALB/c * C57BL/6	embryonic lethality between implantation and somite formation, complete penetrance	J:139668
Gpx4tm2Marc/Gpx4tm2Marc Tg(Camk2a-cre)2Gsc/0 involves: 129P2/OlaHsd * FVB/N	abnormal hippocampus CA3 region morphology	J:139668
	abnormal social/conspecific interaction behavior	J:139668
	abnormal somatosensory cortex morphology	J:139668
	astrocytosis	J:139668
	ataxia	J:139668
	convulsive seizures	J:139668
	increased neuron apoptosis	J:139668
	postnatal lethality	J:139668
	weight loss	J:139668
Gpx4tm3Marc/Gpx4tm3Marc involves: 129P2/OlaHsd	abnormal sperm head morphology	J:186906
	abnormal sperm mitochondrial sheath morphology	J:186906
	abnormal sperm principal piece morphology	J:186906
	normal cellular phenotype	J:186906
	decreased fertilization frequency	J:186906
	impaired fertilization	J:186906
	kinked sperm flagellum	J:186906
	male infertility	J:186906
	normal reproductive system phenotype	J:186906
Gpx4tm4Marc/Gpx4+ involves: 129S6/SvEvTac * C57BL/6J	abnormal sperm head morphology	J:225651
	abnormal sperm midpiece morphology	J:225651
	abnormal sperm mitochondrial sheath morphology	J:225651
	abnormal sperm motility	J:225651
	abnormal sperm physiology	J:225651
	decreased fertilization frequency	J:225651
	decreased litter size	J:225651
	impaired fertilization	J:225651
	kinked sperm flagellum	J:225651
	reduced male fertility	J:225651
Gpx4tm4Marc/Gpx4tm4Marc involves: 129S6/SvEvTac * C57BL/6J	abnormal embryonic tissue morphology	J:225651
	abnormal extraembryonic tissue morphology	J:225651
	abnormal germ layer development	J:225651
	embryonic lethality between implantation and placentation, complete penetrance	J:225651
	empty decidua capsularis	J:225651
	failure to gastrulate	J:225651