Gpx4^tm1Yana
Targeted Allele Detail

Summary

• Symbol: Gpx4^tm1Yana
• Name: glutathione peroxidase 4; targeted mutation 1, Yasuhito Nakagawa
• MGI ID: MGI:2663628
• Gene: Gpx4 Location: Chr10:79883000-79892273 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Gpx4^tm1Yana page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83472
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All of the exons of the endogenous locus, encompassing the entire coding regions of the mitochondrial, non-mitochondrial, and sperm nuclei isoforms, were replaced with a neomycin selection cassette inserted by homologous recombination. Reduced levels of transcript and protein were observed in various tissues obtained from heterozygous mutant mice. (J:83472)

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpx4 Mutation: 80 strains or lines available

References

• Original: J:83472 Imai H, et al., Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene. Biochem Biophys Res Commun. 2003 May 30;305(2):278-86
• All: 9 reference(s)