Gpx4^tm1Prol
Targeted Allele Detail

Summary

• Symbol: Gpx4^tm1Prol
• Name: glutathione peroxidase 4; targeted mutation 1, Tomas A Prolla
• MGI ID: MGI:2651590
• Synonyms: Gpx4^-
• Gene: Gpx4 Location: Chr10:79883000-79892273 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Gpx4^tm1Prol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82053
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 7 of the endogenous gene were replaced with an hprt cassette inserted by homologous recombination. Transcript and protein levels were reduced by approximately 50% relative to wild-type levels in heart, liver, kidney, brain, and testes tissues. (J:82053)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpx4 Mutation: 80 strains or lines available

References

• Original: J:82053 Yant LJ, et al., The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic Biol Med. 2003 Feb 15;34(4):496-502
• All: 9 reference(s)