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Lepr Gene Detail
Summary
  • Symbol
    Lepr
  • Name
    leptin receptor
  • Synonyms
    Leprb, LEPROT, leptin receptor gene-related protein, Modb1, obese-like, obl, Obr, OB-RGRP
  • Feature Type
    protein coding gene
  • IDs
    MGI:104993
    NCBI Gene: 16847
  • Alliance
  • Transcription Start Sites
    8 TSS
  • Candidate for QTL
    5 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:101574601-101672549 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 46.96 cM
  • Mapping Data
    26 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2478 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104993
protein coding gene Chr4:101574393-101676375 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028495
protein coding gene Chr4:102035017-102133442 (+)
A/J MGP_AJ_G0028458
protein coding gene Chr4:98469344-98556097 (+)
AKR/J MGP_AKRJ_G0028405
protein coding gene Chr4:100847814-100940547 (+)
BALB/cJ MGP_BALBcJ_G0028476
protein coding gene Chr4:98686364-98780446 (+)
C3H/HeJ MGP_C3HHeJ_G0028189
protein coding gene Chr4:101658146-101748029 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028915
protein coding gene Chr4:105886442-105978637 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026207
protein coding gene Chr4:93738476-93827797 (+)
CAST/EiJ MGP_CASTEiJ_G0027629
protein coding gene Chr4:99445243-99612951 (+)
CBA/J MGP_CBAJ_G0028158
protein coding gene Chr4:109217703-109320032 (+)
DBA/2J MGP_DBA2J_G0028308
protein coding gene Chr4:98161318-98253235 (+)
FVB/NJ MGP_FVBNJ_G0028275
protein coding gene Chr4:97005246-97096556 (+)
LP/J MGP_LPJ_G0028408
protein coding gene Chr4:102339642-102438731 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028303
protein coding gene Chr4:114751153-114854079 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028953
protein coding gene Chr4:101110668-101268560 (+)
PWK/PhJ MGP_PWKPhJ_G0027354
protein coding gene Chr4:96342329-96428860 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027176
protein coding gene Chr4:98557873-98643336 (+)
WSB/EiJ MGP_WSBEiJ_G0027707
protein coding gene Chr4:101275652-101449429 (+)



Homology
more
  • Human Ortholog
    LEPR, leptin receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LEPR, leptin receptor
  • Synonyms
    CD295, LEP-R, LEPRD, OB-R, OBR
  • Links
    NCBI Gene ID: 3953
    neXtProt AC: NX_P48357
    UniProt: P48357

  • Chr Location
    1p31.3; chr1:65420652-65641559 (+)  GRCh38

Human Diseases
more
  • Diseases
    3 with Lepr mouse models; 11 with human LEPR associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 21 models
IDs
View 8 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    16 with disease annotations
  • References
    28 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    334 phenotypes from 42 alleles in 73 genetic backgrounds
    113 phenotypes from multigenic genotypes
    6 images
    2463 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants are hyperphagic, low-activity, poorly cold-adapted, sterile and have enhanced fat conversion. They are obese, hyperinsulinemic and, on certain strains, severely hyperglycemic. Heterozygotes are normal but resistant to prolonged fasting.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057722 Ensembl Gene Model | MGI Sequence Detail 97949 C57BL/6J ±  kb
    transcript ENSMUST00000037552 Ensembl | MGI Sequence Detail 4127 Not Applicable  
    polypeptide ENSMUSP00000037385 Ensembl | MGI Sequence Detail 1162 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      Genomic 24
      cDNA 30
      Primer pair 10
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12969, MGD-MRK-31066, MGD-MRK-8799
    References
    more
    • Summaries
      All 2679
      Developmental Gene Expression 37
      Diseases 28
      Gene Ontology 21
      Phenotypes 2463
    • Earliest
      J:31691 Falconer DS, et al., Adipose, a new inherited obesity of the mouse. J Hered. 1959;50(6):290-292
    • Latest
      J:358232 Nishimura S, et al., LRP1-deficient leptin receptor-positive cells in periodontal ligament tissue reduce alveolar bone mass by inhibiting bone formation. Arch Oral Biol. 2024 Feb;158:105853

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory