Phenotypes Associated with This Genotype

Genotype
MGI:2663736

• Allelic Composition: Lepr^db-Pas/Lepr^db-Pas
• Genetic Background: involves: DW/Pas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:174584 , J:31095 )

• visible in 3 to 4 week old mice (J:174584)

• mice become grossly obese, gaining weight until at least 16 months of age (J:174584)

enlarged liver ( J:174584 )

• observed at 24 weeks of age

enlarged spleen ( J:174584 )

• observed at 24 weeks of age

adipose tissue

increased brown adipose tissue amount ( J:174584 )

• mutant mice have twice as much interscapular fat mass compared with non-obese control mice

increased total body fat amount ( J:174584 )

• detected by 6 months of age

• males show a hypertrophic obesity whereas females display both an enlargement and an increase in number of fat cells

• total mitochondrial protein of brown fat is reduced

behavior/neurological

polyphagia ( J:174584 )

• moderate increase in food intake compared with homozygous Lepr^ob mice

homeostasis/metabolism

hyperglycemia ( J:174584 )

• blood glucoes levels are slightly elevated in males; females are normal

increased circulating insulin level ( J:174584 )

• detected by 6 months of age

increased circulating cholesterol level ( J:174584 )

• detected by 6 months of age

reproductive system

female infertility ( J:174584 )

♀

male infertility ( J:174584 )

♂

hematopoietic system

enlarged spleen ( J:174584 )

• observed at 24 weeks of age

immune system

enlarged spleen ( J:174584 )

• observed at 24 weeks of age

liver/biliary system

enlarged liver ( J:174584 )

• observed at 24 weeks of age

muscle

decreased muscle weight ( J:174584 )

• observed at 24 weeks of age

limbs/digits/tail

short femur ( J:174584 )

• at 24 weeks of age mutant mice have significantly shortened femurs compared with those of normal mice

short tail ( J:174584 )

• at 24 weeks of age tails of mutant mice are significantly shorter compared with those of normal mice

skeleton

short femur ( J:174584 )

• at 24 weeks of age mutant mice have significantly shortened femurs compared with those of normal mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:31095