Symbol
Name
ID

Lepr
leptin receptor
MGI:104993

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Increased LDL cholesterol concentration	Hypercholesterolemia	Hypertriglyceridemia	Decreased resting energy expenditure	Glucose intolerance	Diabetes mellitus	Type II diabetes mellitus	Impaired glucose tolerance	Insulin resistance	Hepatic steatosis
Disease(s) Associated with LEPR	Increased LDL cholesterol concentration	Hypercholesterolemia	Hypertriglyceridemia	Decreased resting energy expenditure	Glucose intolerance	Diabetes mellitus	Type II diabetes mellitus	Impaired glucose tolerance	Insulin resistance	Hepatic steatosis
coronary artery disease
metabolic dysfunction-associated steatotic liver disease
obesity
type 2 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

abnormal response to cardiac infarction

abnormal vascular wound healing

increased glucagon secretion

abnormal insulin secretion

decreased insulin secretion

increased insulin secretion

increased susceptibility to diet-induced obesity

increased glycosylated hemoglobin level

impaired adaptive thermogenesis

increased blood uric acid level

increased circulating fructosamine level

abnormal circulating glucose level

increased fasting circulating glucose level

decreased circulating glucose level

hypoglycemia

increased circulating glucose level

hyperglycemia

decreased circulating adrenaline level

increased circulating glucagon level

increased circulating corticosterone level

abnormal circulating insulin level

decreased circulating insulin level

increased circulating insulin level

decreased circulating leptin level

increased circulating leptin level

decreased circulating noradrenaline level

decreased circulating growth hormone level

decreased circulating thyroxine level

increased circulating ketone body level

abnormal circulating lipid level

abnormal circulating cholesterol level

increased circulating HDL cholesterol level

increased circulating LDL cholesterol level

increased circulating VLDL cholesterol level

decreased circulating cholesterol level

increased circulating cholesterol level

increased circulating free fatty acids level

decreased circulating triglyceride level

increased circulating triglyceride level

hyperlipidemia

increased circulating calcium level

increased circulating iron level

increased circulating phosphate level

increased circulating potassium level

increased circulating interleukin-6 level

increased circulating alanine transaminase level

increased circulating alkaline phosphatase level

increased circulating amylase level

increased circulating aspartate transaminase level

increased circulating serum albumin level

increased circulating total protein level

abnormal body temperature

decreased body temperature

decreased core body temperature

abnormal body temperature homeostasis

abnormal circadian temperature homeostasis

abnormal energy expenditure

decreased energy expenditure

abnormal carbon dioxide production

decreased carbon dioxide production

increased carbon dioxide production

abnormal oxygen consumption

decreased oxygen consumption

increased oxygen consumption

decreased respiratory quotient

increased respiratory quotient

abnormal glucose homeostasis

abnormal gluconeogenesis

impaired glucose tolerance

improved glucose tolerance

increased liver glycogen level

increased urine glucose level

increased insulin sensitivity

insulin resistance

abnormal hormone level

decreased circulating adiponectin level

decreased follicle stimulating hormone level

decreased circulating chloride level

increased cholesterol level

abnormal lipid level

decreased prostaglandin level

decreased liver triglyceride level

increased liver triglyceride level

abnormal chemokine level

abnormal interleukin level

increased susceptibility to non-insulin-dependent diabetes

increased susceptibility to diet-induced non-insulin dependent diabetes

decreased urine albumin level

increased urine protein level

albuminuria

abnormal enzyme/coenzyme activity

abnormal nucleotide metabolism

abnormal peptide metabolism

abnormal response/metabolism to endogenous compounds

delayed wound healing

Availability

Mouse Genotype

Lepr^brta/Lepr^brta

Lepr^db-2J/Lepr^db-2J

Lepr^db-3J/Lepr^db-3J

Lepr^db-5J/Lepr^db-5J

Lepr^db-9J/Lepr^db-9J

Lepr^db-ad/Lepr^db-ad

Lepr^Db-Btlr/Lepr^Db-Btlr

Lepr^db-lb/Lepr^db-lb

Lepr^db-NCSU/Lepr^db-NCSU

Lepr^db-Nokl/Lepr^db-Nokl

Lepr^db-rtnd/Lepr^db-rtnd

Lepr^db/Lepr^db

Lepr^KK/Lepr^KK

Lepr^m3Btlr/Lepr^m3Btlr

Lepr^m5Btlr/Lepr^m5Btlr

Lepr^m7Btlr/Lepr^m7Btlr

Lepr^tm1.1Chua/Lepr^tm1.1Chua

Lepr^tm1.1Rll/Lepr^tm1.1Rll

Lepr^tm1.2Chua/Lepr^tm1.2Chua

Lepr^{tm1b(EUCOMM)Wtsi}/Lepr^{tm1b(EUCOMM)Wtsi}

Lepr^tm1Chua/Lepr^tm1Chua

Lepr^tm1Jke/Lepr^tm1Jke

Lepr^tm1Mgmj/Lepr^tm1Mgmj

Lepr^tm1Yli/Lepr^tm1Yli

Lepr^tm2Mgmj/Lepr^tm2Mgmj

Lepr^tm2Yli/Lepr^tm2Yli

Lepr^tm3.1Yli/Lepr^tm3.1Yli

Lepr^tm4Mgmj/Lepr^tm4Mgmj

Lepr^tm5Mgmj/Lepr^tm5Mgmj

Lepr^db/Lepr⁺

Lepr^db/Lepr^db-Nokl

Lepr^tm2Mgmj/Lepr⁺

Tg(Apoe-Lepr)1Kry/0

Lepr^tm1.1Chua/Lepr^tm1.1Chua
Tg(Pomc1-cre)16Lowl/0 (conditional)

Lepr^tm1.1Chua/Lepr^tm1.1Chua
Tg(Nr5a1-cre)2Lowl/0 (conditional)

Lepr^tm1.1Chua/Lepr^tm1.1Chua
Tg(Nr5a1-cre)2Lowl/0
Tg(Pomc1-cre)16Lowl/0 (conditional)

Lepr^tm1.1Chua/Lepr^tm1.1Chua
Tg(Syn1-cre)671Jxm/0 (conditional)

Lepr^tm1.1Chua/Lepr^tm1.1Chua
Tg(Gh1-cre)bKnmn/0 (conditional)

Lepr^tm1.1Chua/Lepr^tm1.1Chua
Slc17a6^tm2(cre)Lowl/Slc17a6⁺ (conditional)

Lepr^tm1.1Chua/Lepr^tm1.1Chua
Slc32a1^tm2(cre)Lowl/Slc32a1⁺ (conditional)

Lepr^tm1.1Chua/Lepr^tm1.1Chua
Nts^tm1(cre)Mgmj/Nts⁺ (conditional)

Lepr^tm1.1Chua/Lepr^tm1.1Chua
Tg(Agrp-cre)1Gsb/0 (conditional)

Lepr^tm1.1Chua/Lepr^tm1.1Chua
Prlh^tm1(cre)Smln/Prlh⁺ (conditional)

Lepr^tm1.1Chua/Lepr^tm1.1Chua
Pgr^tm2(cre)Lyd/Pgr⁺ (conditional)

Lepr^tm1Jke/Lepr^tm1Jke
Tg(Pomc1-cre)16Lowl/0 (conditional)

Lepr^tm1.1Chua/Lepr^tm1.2Chua
Nos1^tm1(cre)Mgmj/Nos1⁺ (conditional)

Lepr^tm1Rck/Lepr^tm1.1Rck
Tg(Syn1-cre)671Jxm/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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