Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Mmp14

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes MMP14
- Mouse genes Mmp14
- Rat genes Mmp14
- Zfish genes mmp14a,mmp14b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mmp14

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	MMP14	IDA		Human	PMID:20666777
Molecular Function	GO:0005178	integrin binding	Mmp14	IPI	RGD:2927	Rat	PMID:19027888\|RGD:2307395
Molecular Function	GO:0070006	metalloaminopeptidase activity	MMP14	IDA		Human	PMID:24970228
Molecular Function	GO:0004222	metalloendopeptidase activity	Mmp14	IMP		Mouse	MGI:MGI:5699659\|PMID:24990232
Molecular Function	GO:0004222	metalloendopeptidase activity	Mmp14	IDA		Mouse	MGI:MGI:5013661\|PMID:21572390
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:Q9BV57	Human	PMID:14718544
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:P56945	Human	PMID:18164686
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:P09958	Human	PMID:20608975
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:Q9R064	Human	PMID:20608975
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:Q9H7M9	Human	PMID:20666777
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:P22455	Human	PMID:20798051
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:P09958	Human	PMID:21152186
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:P53667	Human	PMID:21219645
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:Q61483	Human	PMID:21572390
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:Q10589	Human	PMID:22065321
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:P16035	Human	PMID:24112707
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:P51884	Human	PMID:25304424
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:Q8N6L0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:P27105	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:Q13643	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:Q15125	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:Q15800	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:Q7Z5P4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:Q96AP4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:Q9GZR5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MMP14	IPI	UniProtKB:Q9Y624	Human	PMID:32296183
Cellular Component	GO:0005737	cytoplasm	MMP14	IDA		Human	PMID:22065321
Cellular Component	GO:0005737	cytoplasm	Mmp14	IDA		Rat	PMID:16740171\|RGD:1582597
Cellular Component	GO:0031410	cytoplasmic vesicle	MMP14	IDA		Human	PMID:24859005
Cellular Component	GO:0005829	cytosol	MMP14	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005615	extracellular space	MMP14	IMP		Human	PMID:24784232
Cellular Component	GO:0005925	focal adhesion	MMP14	HDA		Human	PMID:21423176
Cellular Component	GO:0045111	intermediate filament cytoskeleton	MMP14	IDA		Human	GO_REF:0000052
Cellular Component	GO:0044354	macropinosome	MMP14	IDA		Human	PMID:24859005
Cellular Component	GO:0005634	nucleus	MMP14	IMP		Human	PMID:24784232
Cellular Component	GO:0005886	plasma membrane	MMP14	IDA		Human	PMID:15351710
Cellular Component	GO:0005886	plasma membrane	MMP14	IDA		Human	PMID:24859005
Biological Process	GO:0001525	angiogenesis	Mmp14	IEP		Rat	PMID:14766216\|RGD:1582561
Biological Process	GO:0009948	anterior/posterior axis specification	mmp14a	IMP		Zfish	PMID:12853038
Biological Process	GO:0009948	anterior/posterior axis specification	mmp14b	IMP		Zfish	PMID:12853038
Biological Process	GO:0043615	astrocyte cell migration	Mmp14	IEP		Rat	PMID:16265672\|RGD:1582598
Biological Process	GO:0060348	bone development	Mmp14	IGI	MGI:MGI:1276107	Mouse	PMID:18022611
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	Mmp14	IMP	MGI:MGI:2386246	Mouse	PMID:15572153
Biological Process	GO:0051216	cartilage development	mmp14a	IMP	ZFIN:ZDB-MRPHLNO-050208-7	Zfish	PMID:12853038
Biological Process	GO:0051216	cartilage development	mmp14b	IMP	ZFIN:ZDB-MRPHLNO-050208-8	Zfish	PMID:12853038
Biological Process	GO:0016477	cell migration	Mmp14	IMP	MGI:MGI:2386246	Mouse	PMID:15572153
Biological Process	GO:0016477	cell migration	mmp14b	IGI	ZFIN:ZDB-GENE-030901-2,ZFIN:ZDB-GENE-011119-1	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	mmp14a	IGI	ZFIN:ZDB-GENE-030901-1	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	mmp14a	IMP	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	mmp14b	IGI	ZFIN:ZDB-GENE-030901-2	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	mmp14a	IMP	ZFIN:ZDB-GENO-120430-1	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	mmp14b	IGI	ZFIN:ZDB-GENE-030901-1,ZFIN:ZDB-GENE-030901-2	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	mmp14b	IMP	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	mmp14a	IGI	ZFIN:ZDB-GENE-030901-1,ZFIN:ZDB-GENE-030901-2	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	mmp14b	IMP	ZFIN:ZDB-GENO-120430-1	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	mmp14a	IGI	ZFIN:ZDB-GENE-030901-1,ZFIN:ZDB-GENE-011119-1	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	mmp14b	IGI	ZFIN:ZDB-GENE-030901-1	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	mmp14a	IGI	ZFIN:ZDB-GENE-030901-2,ZFIN:ZDB-GENE-011119-1	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	mmp14b	IGI	ZFIN:ZDB-GENE-030901-1,ZFIN:ZDB-GENE-011119-1	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	mmp14a	IGI	ZFIN:ZDB-GENE-030901-2	Zfish	PMID:30082271
Biological Process	GO:0042074	cell migration involved in gastrulation	mmp14a	IGI	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:18423448
Biological Process	GO:0042074	cell migration involved in gastrulation	mmp14b	IGI	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:18423448
Biological Process	GO:0035988	chondrocyte proliferation	Mmp14	IGI	MGI:MGI:1276107	Mouse	PMID:18022611
Biological Process	GO:0030574	collagen catabolic process	Mmp14	IGI	MGI:MGI:1276107	Mouse	PMID:18022611
Biological Process	GO:0060026	convergent extension	mmp14a	IGI	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5,ZFIN:ZDB-MRPHLNO-101124-1	Zfish	PMID:20837484
Biological Process	GO:0060026	convergent extension	mmp14b	IGI	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5,ZFIN:ZDB-MRPHLNO-101124-1	Zfish	PMID:20837484
Biological Process	GO:0060027	convergent extension involved in gastrulation	mmp14a	IGI	ZFIN:ZDB-GENO-070906-1,ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:18423448
Biological Process	GO:0060027	convergent extension involved in gastrulation	mmp14a	IMP	ZFIN:ZDB-MRPHLNO-081029-4	Zfish	PMID:18423448
Biological Process	GO:0060027	convergent extension involved in gastrulation	mmp14a	IGI	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:18423448
Biological Process	GO:0060027	convergent extension involved in gastrulation	mmp14b	IGI	ZFIN:ZDB-GENO-070906-1,ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:18423448
Biological Process	GO:0060027	convergent extension involved in gastrulation	mmp14b	IMP	ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:18423448
Biological Process	GO:0060027	convergent extension involved in gastrulation	mmp14b	IGI	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:18423448
Biological Process	GO:0097094	craniofacial suture morphogenesis	Mmp14	IGI	MGI:MGI:1276107	Mouse	PMID:18022611
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	Mmp14	IGI	MGI:MGI:1276107	Mouse	PMID:18022611
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	mmp14a	IMP	ZFIN:ZDB-MRPHLNO-081029-4	Zfish	PMID:18423448
Biological Process	GO:0001958	endochondral ossification	Mmp14	IGI	MGI:MGI:1276107	Mouse	PMID:18022611
Biological Process	GO:0001958	endochondral ossification	mmp14b	IGI	ZFIN:ZDB-GENO-200618-12	Zfish	PMID:29741626
Biological Process	GO:0001958	endochondral ossification	mmp14a	IGI	ZFIN:ZDB-GENO-200618-12	Zfish	PMID:29741626
Biological Process	GO:0035987	endodermal cell differentiation	MMP14	IEP		Human	PMID:23154389
Biological Process	GO:0001935	endothelial cell proliferation	Mmp14	IEP		Rat	PMID:14766216\|RGD:1582561
Biological Process	GO:0030010	establishment of cell polarity	mmp14a	IGI	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:18423448
Biological Process	GO:0030010	establishment of cell polarity	mmp14b	IGI	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:18423448
Biological Process	GO:0060322	head development	Mmp14	IMP	MGI:MGI:3763359	Mouse	PMID:26234751
Biological Process	GO:0001957	intramembranous ossification	mmp14b	IGI	ZFIN:ZDB-GENO-200618-12	Zfish	PMID:29741626
Biological Process	GO:0001957	intramembranous ossification	mmp14a	IGI	ZFIN:ZDB-GENO-200618-12	Zfish	PMID:29741626
Biological Process	GO:0097581	lamellipodium organization	mmp14a	IGI	ZFIN:ZDB-GENE-030901-2,ZFIN:ZDB-GENE-011119-1	Zfish	PMID:30082271
Biological Process	GO:0097581	lamellipodium organization	mmp14b	IGI	ZFIN:ZDB-GENE-030901-1	Zfish	PMID:30082271
Biological Process	GO:0097581	lamellipodium organization	mmp14b	IGI	ZFIN:ZDB-GENE-030901-1,ZFIN:ZDB-GENE-011119-1	Zfish	PMID:30082271
Biological Process	GO:0097581	lamellipodium organization	mmp14a	IGI	ZFIN:ZDB-GENE-030901-2	Zfish	PMID:30082271
Biological Process	GO:0097581	lamellipodium organization	mmp14a	IMP	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:30082271
Biological Process	GO:0097581	lamellipodium organization	mmp14b	IMP	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:30082271
Biological Process	GO:0030324	lung development	Mmp14	IMP	MGI:MGI:2386246	Mouse	PMID:15572153
Biological Process	GO:0008584	male gonad development	Mmp14	IEP		Rat	PMID:22152881\|RGD:7207280
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	Mmp14	IDA		Rat	PMID:15044209\|RGD:1582604
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	Mmp14	IMP		Mouse	MGI:MGI:5013661\|PMID:21572390
Biological Process	GO:0003407	neural retina development	mmp14a	IMP	ZFIN:ZDB-MRPHLNO-081029-4	Zfish	PMID:23326364
Biological Process	GO:0001503	ossification	Mmp14	IGI	MGI:MGI:1276107	Mouse	PMID:18022611
Biological Process	GO:0001503	ossification	Mmp14	IEP		Rat	PMID:15883642\|RGD:1582555
Biological Process	GO:0001541	ovarian follicle development	Mmp14	IEP		Rat	PMID:15617683\|RGD:1582601
Biological Process	GO:0045579	positive regulation of B cell differentiation	Mmp14	IMP		Mouse	MGI:MGI:5013661\|PMID:21572390
Biological Process	GO:0030307	positive regulation of cell growth	MMP14	IDA		Human	PMID:22065321
Biological Process	GO:0030335	positive regulation of cell migration	MMP14	IDA		Human	PMID:22065321
Biological Process	GO:1905523	positive regulation of macrophage migration	Mmp14	IMP		Mouse	MGI:MGI:5699659\|PMID:24990232
Biological Process	GO:0010831	positive regulation of myotube differentiation	Mmp14	IMP		Mouse	MGI:MGI:5013661\|PMID:21572390
Biological Process	GO:0010954	positive regulation of protein processing	Mmp14	IMP		Rat	PMID:14668206\|RGD:1582606
Biological Process	GO:0006508	proteolysis	MMP14	IDA		Human	PMID:15863497
Biological Process	GO:0006508	proteolysis	MMP14	IDA		Human	PMID:24970228
Biological Process	GO:0030334	regulation of cell migration	mmp14a	IGI	ZFIN:ZDB-GENE-030901-2,ZFIN:ZDB-GENE-011119-1	Zfish	PMID:30082271
Biological Process	GO:0030334	regulation of cell migration	mmp14b	IGI	ZFIN:ZDB-GENE-030901-1,ZFIN:ZDB-GENE-011119-1	Zfish	PMID:30082271
Biological Process	GO:0030334	regulation of cell migration	mmp14a	IGI	ZFIN:ZDB-GENE-030901-2	Zfish	PMID:30082271
Biological Process	GO:0030334	regulation of cell migration	mmp14b	IGI	ZFIN:ZDB-GENE-030901-1	Zfish	PMID:30082271
Biological Process	GO:0030334	regulation of cell migration	mmp14a	IMP	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:30082271
Biological Process	GO:0030334	regulation of cell migration	mmp14b	IMP	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:30082271
Biological Process	GO:1901201	regulation of extracellular matrix assembly	mmp14a	IMP	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:30082271
Biological Process	GO:1901201	regulation of extracellular matrix assembly	mmp14a	IGI	ZFIN:ZDB-GENE-030901-2,ZFIN:ZDB-GENE-011119-1	Zfish	PMID:30082271
Biological Process	GO:1901201	regulation of extracellular matrix assembly	mmp14a	IGI	ZFIN:ZDB-GENE-030901-2	Zfish	PMID:30082271
Biological Process	GO:1901201	regulation of extracellular matrix assembly	mmp14b	IGI	ZFIN:ZDB-GENE-030901-1	Zfish	PMID:30082271
Biological Process	GO:1901201	regulation of extracellular matrix assembly	mmp14b	IMP	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:30082271
Biological Process	GO:1901201	regulation of extracellular matrix assembly	mmp14b	IGI	ZFIN:ZDB-GENE-030901-1,ZFIN:ZDB-GENE-011119-1	Zfish	PMID:30082271
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	MMP14	IMP		Human	PMID:20666777
Biological Process	GO:0043627	response to estrogen	Mmp14	IEP		Rat	PMID:15053235\|RGD:1582603
Biological Process	GO:0009725	response to hormone	Mmp14	IDA		Rat	PMID:14668206\|RGD:1582606
Biological Process	GO:0001666	response to hypoxia	Mmp14	IEP		Rat	PMID:16980344\|RGD:1582594
Biological Process	GO:0001666	response to hypoxia	mmp14a	IDA		Zfish	PMID:15994372
Biological Process	GO:0009612	response to mechanical stimulus	Mmp14	IEP		Rat	PMID:15350851\|RGD:1582602
Biological Process	GO:1990834	response to odorant	Mmp14	IEP		Rat	PMID:23103411\|RGD:11530015
Biological Process	GO:0014070	response to organic cyclic compound	Mmp14	IEP		Rat	PMID:11125539\|RGD:2314953
Biological Process	GO:0006979	response to oxidative stress	Mmp14	IEP		Rat	PMID:15642321\|RGD:1582600
Biological Process	GO:0010842	retina layer formation	mmp14a	IMP	ZFIN:ZDB-MRPHLNO-081029-4	Zfish	PMID:23326364
Biological Process	GO:0031290	retinal ganglion cell axon guidance	mmp14a	IGI	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-130220-4	Zfish	PMID:23326364
Biological Process	GO:0031290	retinal ganglion cell axon guidance	mmp14a	IMP	ZFIN:ZDB-MRPHLNO-081029-4	Zfish	PMID:23326364
Biological Process	GO:0048771	tissue remodeling	Mmp14	IDA		Rat	PMID:16740171\|RGD:1582597
Biological Process	GO:0031638	zymogen activation	MMP14	IDA		Human	PMID:20666777
Biological Process	GO:0031638	zymogen activation	Mmp14	IMP	MGI:MGI:2386246	Mouse	PMID:15572153

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/21/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.