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Mmp14 Gene Detail
Summary
  • Symbol
    Mmp14
  • Name
    matrix metallopeptidase 14 (membrane-inserted)
  • Synonyms
    Membrane type 1-MMP, MT1-MMP, sabe
  • Feature Type
    protein coding gene
  • IDs
    MGI:101900
    NCBI Gene: 17387
  • Gene Overview
    MyGene.info: MMP14
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54431598-54442456 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 27.79 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101900
protein coding gene Chr14:54431598-54445364 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021309
protein coding gene Chr14:48377410-48386894 (+)
A/J MGP_AJ_G0021268
protein coding gene Chr14:47442367-47453044 (+)
AKR/J MGP_AKRJ_G0021244
protein coding gene Chr14:49156082-49165568 (+)
BALB/cJ MGP_BALBcJ_G0021272
protein coding gene Chr14:47412017-47421514 (+)
C3H/HeJ MGP_C3HHeJ_G0021052
protein coding gene Chr14:48840637-48850195 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021711
protein coding gene Chr14:50836333-50846840 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019255
protein coding gene Chr14:45860422-45869894 (+)
CAST/EiJ MGP_CASTEiJ_G0020571
protein coding gene Chr14:45083424-45094093 (+)
CBA/J MGP_CBAJ_G0021019
protein coding gene Chr14:52337708-52348381 (+)
DBA/2J MGP_DBA2J_G0021140
protein coding gene Chr14:47186054-47196740 (+)
FVB/NJ MGP_FVBNJ_G0021122
protein coding gene Chr14:46639096-46648580 (+)
LP/J MGP_LPJ_G0021214
protein coding gene Chr14:49385992-49395680 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021146
protein coding gene Chr14:51778127-51788780 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021737
protein coding gene Chr14:48338558-48349948 (+)
PWK/PhJ MGP_PWKPhJ_G0020317
protein coding gene Chr14:43712481-43723299 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020145
protein coding gene Chr14:44330200-44340860 (+)
WSB/EiJ MGP_WSBEiJ_G0020624
protein coding gene Chr14:48637475-48647547 (+)



Homology
more
  • Human Ortholog
    MMP14, matrix metallopeptidase 14
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MMP14, matrix metallopeptidase 14
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MMP-14, MMP-X1, MT1MMP, MT1-MMP, MT-MMP, MTMMP1, MT-MMP 1, WNCHRS
  • Links
    NCBI Gene ID: 4323
    neXtProt AC: NX_P50281
    UniProt: P50281

  • Chr Location
    14q11.2; chr14:22836533-22847600 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Mmp14 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    121 phenotypes from 7 alleles in 11 genetic backgrounds
    53 phenotypes from multigenic genotypes
    2 images
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mutations may lead to postnatal or premature death, craniofacial anomalies, skeletal dysplasia, low body weight, reduced bone formation and chondrocyte proliferation, arthritis, and fibrosis as well as defects in angiogenesis and lung, tooth,kidney, and submaxillary gland development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17387 NCBI Gene Model | MGI Sequence Detail 10859 C57BL/6J ±  kb
    transcript NM_008608 RefSeq | MGI Sequence Detail 3801 C57BL/6  
    polypeptide P53690 UniProt | EBI | MGI Sequence Detail 582 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 2
      cDNA 20
      Primer pair 6
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18727, MGI:2145621, MGI:3717409
    References
    more
    • Summaries
      All 162
      Developmental Gene Expression 44
      Diseases 1
      Gene Ontology 11
      Phenotypes 69
    • Earliest
      J:22683 Sato H, et al., A matrix metalloproteinase expressed on the surface of invasive tumour cells [see comments]. Nature. 1994 Jul 7;370(6484):61-5
    • Latest
      J:258136 Sanz RL, et al., MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding. J Neurosci. 2018 Jan 17;38(3):518-529

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory