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Mmp14 Gene Detail
Summary
  • Symbol
    Mmp14
  • Name
    matrix metallopeptidase 14 (membrane-inserted)
  • Synonyms
    Membrane type 1-MMP, MT1-MMP, sabe
  • Feature Type
    protein coding gene
  • IDs
    MGI:101900
    NCBI Gene: 17387
  • Gene Overview
    MyGene.info: MMP14
Location & Maps
more
  • Sequence Map
    Chr14:54431612-54441265 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9654 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 27.79 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    MMP14, matrix metallopeptidase 14
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MMP14, matrix metallopeptidase 14
    Orthology source: HomoloGene
  • Synonyms
    MMP-14, MMP-X1, MT1MMP, MT1-MMP, MT-MMP, MTMMP1, MT-MMP 1, WNCHRS
  • Links
    NCBI Gene ID: 4323
    neXtProt AC: NX_P50281

  • Chr Location
    14q11.2; chr14:22836533-22847600 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Mmp14 mouse models; 1 with human MMP14 associations

Human Disease Mouse Models
       Osteopenia and Sparse Hair   OMIM: 259690 View 1 model
Rheumatoid Arthritis; RA   OMIM: 180300 View 1 model
       Winchester Syndrome; WNCHRS   OMIM: 277950
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    116 phenotypes from 7 alleles in 11 genetic backgrounds
    49 phenotypes from multigenic genotypes
    2 images
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Spontaneous
    1
  • Targeted
    11
  • Genomic Mutations
    1 involving Mmp14
  • Incidental Mutations
Nullizygous mutations may lead to postnatal or premature death, craniofacial anomalies, skeletal dysplasia, low body weight, reduced bone formation and chondrocyte proliferation, arthritis, and fibrosis as well as defects in angiogenesis and lung, tooth,kidney, and submaxillary gland development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053900 VEGA Gene Model | MGI Sequence Detail 9654 C57BL/6J ±  kb
transcript OTTMUST00000134095 VEGA | MGI Sequence Detail 2596 Not Applicable  
polypeptide OTTMUSP00000071180 VEGA | MGI Sequence Detail 582 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    87 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    Genomic 2
    cDNA 19
    Primer pair 5
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-18727, MGI:2145621, MGI:3717409
References
more
  • Summaries
    All 137
    Developmental Gene Expression 38
    Diseases 1
    Gene Ontology 7
    Phenotypes 63
  • Earliest
    J:22683 Sato H, et al., A matrix metalloproteinase expressed on the surface of invasive tumour cells [see comments]. Nature. 1994 Jul 7;370(6484):61-5
  • Latest
    J:227080 Taylor SH, et al., Matrix metalloproteinase 14 is required for fibrous tissue expansion. Elife. 2015;4:e09345

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory