Mmp14
Gene Detail

Symbol Name ID

Mmp14 matrix metallopeptidase 14 (membrane-inserted) MGI:101900

Synonyms

Membrane type 1-MMP, MT1-MMP, sabe

Feature Type

protein coding gene

Genetic Map

Chromosome 14

27.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr14:54431604-54441258 bp, + strand From NCBI annotation of GRCm38   9655 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21040  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp14

Human homologs

Human Homolog		MMP14, matrix metallopeptidase 14 (membrane-inserted)
NCBI Gene ID		4323
neXtProt AC		NX_P50281
Human Synonyms		1, MMP-14, MMP-X1, MT1MMP, MT1-MMP, MT-MMP, MTMMP1, MT-MMP 1
Human Chr (Location)		14q11-q12; chr14:23305793-23316803 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(16) : Targeted(8) Gene trapped(6) Spontaneous(1) Chemically induced(1)
 

Nullizygous mutations may lead to postnatal or premature death, craniofacial anomalies, skeletal dysplasia, low body weight, reduced bone formation and chondrocyte proliferation, arthritis, and fibrosis as well as defects in angiogenesis and lung, tooth, kidney, and submaxillary gland development.

 
Human Diseases Modeled Using Mouse Mmp14 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	branching morphogenesis of an epithelial tube, cell migration, ...
Component	cytoplasm, extracellular matrix, ...
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (32 records)
Data Summary: Results (65)    Tissues (13)    Images (28)
Theiler Stages: 17, 19, 22, 23, 25, 28

Assay Type	Results
RNA in situ	50
RT-PCR	15

cDNA source data(202)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(211) Genomic(2) cDNA(203) Primer pair(5) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000000957 (Evidence)
Entrez Gene	17387 (Evidence)
UniGene	280175
DFCI	TC1572262
DoTS	DT.87072804
NIA Mouse Gene Index	U015622
EC	3.4.24.80
Consensus CDS Project	CCDS36922.1
International Mouse Knockout Project Status	Mmp14

Sequences

Length	Strain/Species
genomic	17387	NCBI Gene Model | MGI Sequence Detail	9655	C57BL/6J
transcript	NM_008608	RefSeq | MGI Sequence Detail	2597	C57BL/6
polypeptide	P53690	UniProt | EBI | MGI Sequence Detail	582	Not Applicable

All sequences(55) RefSeq(2) UniProt(5)

Polymorphisms

PCR(1) : SNPs(44 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000585	Hemopexin/matrixin
InterPro	IPR018486	Hemopexin/matrixin, conserved site
InterPro	IPR018487	Hemopexin/matrixin, repeat
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021158	Peptidase M10A, cysteine switch, zinc binding site
InterPro	IPR021190	Peptidase M10A, matrix metallopeptidase
InterPro	IPR021805	Peptidase M10A, matrix metallopeptidase, C-terminal
InterPro	IPR016293	Peptidase M10A, matrix metallopeptidase, stromelysin type
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010474	matrix metalloproteinase-14

Graphical View of Protein Domain Structure

References

(Earliest) J:22683 Sato H, et al., A matrix metalloproteinase expressed on the surface of invasive tumour cells [see comments]. Nature. 1994 Jul 7;370(6484):61-5
(Latest) J:194480 Ma S, et al., Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling. PLoS Biol. 2013 Jan;11(1):e1001469
All references(126)

Other accession IDs

MGD-MRK-18727, MGI:2145621, MGI:3717409