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Mmp14
Gene Detail
 Symbol
Name
ID
Mmp14
matrix metallopeptidase 14 (membrane-inserted)
MGI:101900
Synonyms Membrane type 1-MMP, MT1-MMP, sabe
Feature Type protein coding gene
Genetic Map
Chromosome 14
27.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr14:54431604-54441258 bp, + strand
From NCBI annotation of GRCm38

  9655 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21040  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp14

Human
homologs
Human Homolog MMP14, matrix metallopeptidase 14 (membrane-inserted)
NCBI Gene ID 4323
neXtProt AC  NX_P50281
Human Synonyms  MMP-14, MMP-X1, MT1MMP, MT1-MMP, MT-MMP, MTMMP1, MT-MMP 1, WNCHRS
Human Chr (Location)  14q11.2; chr14:22836533-22847600 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(1) Gene trapped(6) Spontaneous(1) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mutations may lead to postnatal or premature death, craniofacial anomalies, skeletal dysplasia, low body weight, reduced bone formation and chondrocyte proliferation, arthritis, and fibrosis as well as defects in angiogenesis and lung, tooth, kidney, and submaxillary gland development.
 
Human Diseases Modeled Using Mouse Mmp14 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Mmp14 interacts with 132 markers (Mir10b, Mir15a, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process bone development, branching morphogenesis of an epithelial tube, ...
Component cytoplasm, extracellular matrix, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (65)    Tissues (13)    Images (28)
Theiler Stages: 17, 19, 22, 23, 25, 28
Assay TypeResults
RNA in situ 50
RT-PCR 15
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(2) cDNA(18) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000000957 (Evidence)
Entrez Gene17387 (Evidence)
DFCITC1572262
DoTSDT.87072804
NIA Mouse Gene IndexU015622
EC3.4.24.80
Consensus CDS ProjectCCDS36922.1
International Mouse Knockout Project StatusMmp14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17387 NCBI Gene Model | MGI Sequence Detail 9655 C57BL/6J ±  kb
transcript NM_008608 RefSeq | MGI Sequence Detail 2597 C57BL/6 
polypeptide P53690 UniProt | EBI | MGI Sequence Detail 582 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(2) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(89 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminal
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010474 matrix metalloproteinase-14
Graphical View of Protein Domain Structure
References (Earliest) J:22683 Sato H, et al., A matrix metalloproteinase expressed on the surface of invasive tumour cells [see comments]. Nature. 1994 Jul 7;370(6484):61-5
(Latest) J:198679 Tang Y, et al., MT1-MMP-dependent control of skeletal stem cell commitment via a beta1-integrin/YAP/TAZ signaling axis. Dev Cell. 2013 May 28;25(4):402-16
All references(129)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-18727, MGI:2145621, MGI:3717409

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory