About   Help   FAQ
Targeted Allele Detail
Symbol: Mmp14tm1Hbh
Name: matrix metallopeptidase 14 (membrane-inserted); targeted mutation 1, Henning Birkedal-Hansen
MGI ID: MGI:2445723
Synonyms: Cartoon mice, MT1-, Mt1-MMP
Gene: Mmp14  Location: Chr14:54669055-54679913 bp, + strand  Genetic Position: Chr14, 27.79 cM
Alliance: Mmp14tm1Hbh page
Germline Transmission:  Earliest citation of germline transmission: J:57969
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence encompassing exons 2 through 5, encoding amino acids 6 through 274, was replaced when a PGK-hprt cassette was inserted at the endogenous locus via homologous recombination. The deleted region included all but 5 residues of the prodomain and 8 residues of the catalytic domain. Northern blot analysis using probes for the amino- and carboxyl-terminal untargeted regions indicated a complete absence of transcript produced from the targeted allele. (J:57969)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 30 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mmp14 Mutation:  29 strains or lines available
Original:  J:57969 Holmbeck K, et al., MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell. 1999 Oct 1;99(1):81-92
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory