Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables metalloendopeptidase activity. Involved in negative regulation of Notch signaling pathway; positive regulation of cell differentiation; and positive regulation of macrophage migration. Acts upstream of or within several processes, including chondrocyte proliferation; collagen catabolic process; and skeletal system morphogenesis. Predicted to be located in several cellular components, including cytosol; intermediate filament cytoskeleton; and macropinosome. Predicted to be active in extracellular space and plasma membrane. Predicted to colocalize with cytoplasm. Is expressed in several structures, including embryo mesenchyme; genitourinary system; heart; musculoskeletal system; and sensory organ. Used to study rheumatoid arthritis. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14).