Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GATA6
  • Mouse genes Gata6
  • Rat genes Gata6
  • Zfish genes gata6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gata6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Gata6	IDA		Mouse	PMID:16199866
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Gata6	IDA		Rat	PMID:20855530|RGD:8554432
Molecular Function	GO:0003677	DNA binding	Gata6	IDA		Mouse	PMID:16912278
Molecular Function	GO:0003677	DNA binding	Gata6	IDA		Mouse	PMID:11733512
Molecular Function	GO:0003677	DNA binding	gata6	IDA		Zfish	PMID:24823378
Molecular Function	GO:0003700	DNA-binding transcription factor activity	GATA6	IDA		Human	PMID:19497978
Molecular Function	GO:0003700	DNA-binding transcription factor activity	GATA6	IDA		Human	PMID:19666519
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Gata6	IDA		Mouse	PMID:11914369
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Gata6	IDA		Mouse	PMID:17164424
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Gata6	IDA		Mouse	PMID:16621466
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GATA6	IMP		Human	PMID:21127043
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Gata6	IDA		Mouse	PMID:8660897
Molecular Function	GO:0140297	DNA-binding transcription factor binding	GATA6	IPI	UniProtKB:P08047	Human	PMID:14988427
Molecular Function	GO:0140297	DNA-binding transcription factor binding	GATA6	IPI	UniProtKB:Q03014	Human	PMID:15016828
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Gata6	IPI	UniProtKB:P46152	Rat	PMID:10330176|RGD:8553656
Molecular Function	GO:0003690	double-stranded DNA binding	Gata6	IDA		Rat	PMID:10851229|RGD:2314198
Molecular Function	GO:0051525	NFAT protein binding	GATA6	IPI	UniProtKB:O88942	Human	PMID:11889139
Molecular Function	GO:0005515	protein binding	GATA6	IPI	UniProtKB:Q9DBX7	Human	PMID:16199874
Molecular Function	GO:0005515	protein binding	GATA6	IPI	UniProtKB:Q9QUS4	Human	PMID:16199874
Molecular Function	GO:0005515	protein binding	GATA6	IPI	UniProtKB:Q9WV93	Human	PMID:16199874
Molecular Function	GO:0005515	protein binding	Gata6	IPI	PR:Q8VEE1	Mouse	PMID:16199866
Molecular Function	GO:0005515	protein binding	Gata6	IPI	UniProtKB:O88323	Mouse	PMID:11724781
Molecular Function	GO:0005515	protein binding	Gata6	IPI	PR:P50220	Mouse	PMID:11733512
Molecular Function	GO:0019901	protein kinase binding	GATA6	IPI	UniProtKB:P49841	Human	PMID:20864106
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Gata6	IDA		Mouse	PMID:21350014
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Gata6	IDA		Mouse	PMID:15987774
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Gata6	IDA		Mouse	PMID:16621466
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Gata6	IDA		Mouse	PMID:16199866
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Gata6	IPI	UniProtKB:Q9UBP5	Mouse	MGI:MGI:3610837|PMID:16293227
Molecular Function	GO:0043565	sequence-specific DNA binding	Gata6	IDA		Mouse	PMID:11914369
Molecular Function	GO:0043565	sequence-specific DNA binding	Gata6	IDA		Rat	PMID:8248184|RGD:728607
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	GATA6	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	GATA6	IDA		Human	PMID:18177748
Molecular Function	GO:0000976	transcription cis-regulatory region binding	GATA6	IDA		Human	PMID:19666519
Molecular Function	GO:0000976	transcription cis-regulatory region binding	GATA6	IDA		Human	PMID:20206639
Molecular Function	GO:0000976	transcription cis-regulatory region binding	GATA6	IDA		Human	PMID:9566909
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Gata6	IDA		Rat	PMID:12606287|RGD:8554170
Molecular Function	GO:0001223	transcription coactivator binding	GATA6	IPI	UniProtKB:Q15648	Human	PMID:19497978
Molecular Function	GO:0001223	transcription coactivator binding	Gata6	IPI	UniProtKB:Q925J9	Mouse	MGI:MGI:2158098|PMID:11724781
Molecular Function	GO:0008134	transcription factor binding	Gata6	IPI	PR:P42586	Mouse	PMID:16887115
Cellular Component	GO:0031965	nuclear membrane	GATA6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	GATA6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	GATA6	IDA		Human	PMID:17785913
Cellular Component	GO:0005634	nucleus	GATA6	IDA		Human	PMID:19666519
Cellular Component	GO:0005634	nucleus	GATA6	IDA		Human	PMID:20206639
Cellular Component	GO:0005634	nucleus	GATA6	IDA		Human	PMID:21127043
Cellular Component	GO:0005634	nucleus	GATA6	IDA		Human	PMID:21828274
Cellular Component	GO:0005634	nucleus	GATA6	IDA		Human	PMID:27756709
Cellular Component	GO:0005634	nucleus	GATA6	IDA		Human	PMID:9566909
Cellular Component	GO:0005634	nucleus	GATA6	IDA		Human	PMID:9593712
Cellular Component	GO:0005634	nucleus	Gata6	IDA		Mouse	PMID:12130579
Cellular Component	GO:0005634	nucleus	Gata6	IDA		Mouse	PMID:16199866
Cellular Component	GO:0005634	nucleus	Gata6	IDA		Mouse	PMID:23824537
Cellular Component	GO:0005634	nucleus	Gata6	IDA		Mouse	PMID:20123909
Cellular Component	GO:0005634	nucleus	Gata6	IDA		Mouse	PMID:24036311
Cellular Component	GO:0005634	nucleus	Gata6	IDA		Mouse	PMID:20705924
Cellular Component	GO:0005634	nucleus	Gata6	IDA		Mouse	PMID:16940177
Cellular Component	GO:0005634	nucleus	Gata6	IDA		Rat	PMID:10851229|RGD:2314198
Cellular Component	GO:0005667	transcription regulator complex	Gata6	IDA		Mouse	PMID:17164424
Biological Process	GO:0048645	animal organ formation	Gata6	IMP		Mouse	PMID:16887115
Biological Process	GO:0055007	cardiac muscle cell differentiation	Gata6	IGI	MGI:MGI:95664	Mouse	PMID:18400219
Biological Process	GO:0055007	cardiac muscle cell differentiation	Gata6	IMP	MGI:MGI:3793425	Mouse	PMID:18400219
Biological Process	GO:0060038	cardiac muscle cell proliferation	Gata6	IGI	MGI:MGI:102541	Mouse	PMID:19084512
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	Gata6	IMP	MGI:MGI:3054171,MGI:MGI:3654150	Mouse	PMID:20705924
Biological Process	GO:0048738	cardiac muscle tissue development	Gata6	IGI	MGI:MGI:95664	Mouse	PMID:20705924
Biological Process	GO:0060947	cardiac vascular smooth muscle cell differentiation	GATA6	IMP		Human	PMID:11889139
Biological Process	GO:0060947	cardiac vascular smooth muscle cell differentiation	GATA6	IMP		Human	PMID:12615657
Biological Process	GO:0060975	cardioblast migration to the midline involved in heart field formation	gata6	IGI	ZFIN:ZDB-MRPHLNO-050927-1,ZFIN:ZDB-MRPHLNO-060522-2	Zfish	PMID:19297410
Biological Process	GO:0071773	cellular response to BMP stimulus	Gata6	IDA		Mouse	PMID:20501701
Biological Process	GO:0071371	cellular response to gonadotropin stimulus	Gata6	IDA		Mouse	PMID:9231805
Biological Process	GO:0071456	cellular response to hypoxia	GATA6	IDA		Human	PMID:21127043
Biological Process	GO:0060486	club cell differentiation	Gata6	IGI	MGI:MGI:108067	Mouse	PMID:17164424
Biological Process	GO:0048565	digestive tract development	gata6	IMP	ZFIN:ZDB-MRPHLNO-050927-1	Zfish	PMID:22609551
Biological Process	GO:0035987	endodermal cell differentiation	Gata6	IMP	MGI:MGI:2177785	Mouse	PMID:9832509
Biological Process	GO:0007493	endodermal cell fate determination	Gata6	IDA		Mouse	PMID:20308546
Biological Process	GO:0030855	epithelial cell differentiation	Gata6	IMP		Mouse	PMID:16887115
Biological Process	GO:0070315	G1 to G0 transition involved in cell differentiation	GATA6	IDA		Human	PMID:9593712
Biological Process	GO:0010467	gene expression	Gata6	IMP	MGI:MGI:2177784	Mouse	PMID:33443158
Biological Process	GO:0060047	heart contraction	Gata6	IMP	MGI:MGI:2177784	Mouse	PMID:33443158
Biological Process	GO:0003007	heart morphogenesis	gata6	IMP	ZFIN:ZDB-MRPHLNO-050927-1	Zfish	PMID:17869240
Biological Process	GO:0001701	in utero embryonic development	Gata6	IMP	MGI:MGI:2177785	Mouse	PMID:9832509
Biological Process	GO:0001701	in utero embryonic development	Gata6	IMP	MGI:MGI:3793425	Mouse	PMID:20123909
Biological Process	GO:0060575	intestinal epithelial cell differentiation	GATA6	IDA		Human	PMID:9566909
Biological Process	GO:0001889	liver development	Gata6	IMP	MGI:MGI:3576383	Mouse	PMID:15767668
Biological Process	GO:0001889	liver development	gata6	IMP	ZFIN:ZDB-MRPHLNO-050927-1	Zfish	PMID:17507405
Biological Process	GO:0060430	lung saccule development	Gata6	IGI	MGI:MGI:108067	Mouse	PMID:17164424
Biological Process	GO:0008584	male gonad development	GATA6	IEP		Human	PMID:17848411
Biological Process	GO:0030099	myeloid cell differentiation	gata6	IGI	ZFIN:ZDB-MRPHLNO-050927-1,ZFIN:ZDB-MRPHLNO-060522-2	Zfish	PMID:19297410
Biological Process	GO:0043066	negative regulation of apoptotic process	GATA6	IMP		Human	PMID:21127043
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	GATA6	IDA		Human	PMID:18177748
Biological Process	GO:1902894	negative regulation of miRNA transcription	Gata6	IMP		Rat	PMID:25950484|RGD:11541106
Biological Process	GO:1904003	negative regulation of sebum secreting cell proliferation	GATA6	IDA		Human	PMID:33082341
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	GATA6	IDA		Human	PMID:18177748
Biological Process	GO:0032911	negative regulation of transforming growth factor beta1 production	GATA6	IMP		Human	PMID:21127043
Biological Process	GO:0032912	negative regulation of transforming growth factor beta2 production	GATA6	IMP		Human	PMID:21127043
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Gata6	IEP		Rat	PMID:17923110|RGD:2314196
Biological Process	GO:0003148	outflow tract septum morphogenesis	GATA6	IMP		Human	PMID:19666519
Biological Process	GO:0031016	pancreas development	Gata6	IMP		Mouse	PMID:16887115
Biological Process	GO:0003310	pancreatic A cell differentiation	Gata6	IMP		Mouse	PMID:16887115
Biological Process	GO:0006644	phospholipid metabolic process	Gata6	IGI	MGI:MGI:108067	Mouse	PMID:17164424
Biological Process	GO:0045766	positive regulation of angiogenesis	GATA6	IDA		Human	PMID:21127043
Biological Process	GO:0043065	positive regulation of apoptotic process	Gata6	IMP		Rat	PMID:19628789|RGD:2314195
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	Gata6	IDA		Rat	PMID:12606287|RGD:8554170
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	Gata6	IMP		Rat	PMID:25950484|RGD:11541106
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	Gata6	IGI	MGI:MGI:102541	Mouse	PMID:19084512
Biological Process	GO:0110024	positive regulation of cardiac muscle myoblast proliferation	GATA6	IDA		Human	PMID:25068583
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	GATA6	IMP		Human	PMID:22750565
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	GATA6	IMP		Human	PMID:22824924
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	GATA6	IMP		Human	PMID:27756709
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Gata6	IDA		Mouse	PMID:9738004
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Gata6	IDA		Mouse	PMID:8660897
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Gata6	IDA		Mouse	PMID:11733512
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GATA6	IDA		Human	PMID:19497978
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GATA6	IDA		Human	PMID:19666519
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata6	IGI	MGI:MGI:108067	Mouse	PMID:17164424
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata6	IDA		Mouse	PMID:8660897
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata6	IDA		Mouse	PMID:16199866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata6	IDA		Mouse	PMID:15539431
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata6	IDA		Mouse	PMID:16621466
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata6	IMP	MGI:MGI:2177785	Mouse	PMID:9832509
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata6	IGI	MGI:MGI:106658	Mouse	PMID:16510470
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata6	IMP	MGI:MGI:3623678	Mouse	PMID:21350014
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata6	IGI	MGI:MGI:107516	Mouse	PMID:16510470
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata6	IDA		Mouse	PMID:11914369
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata6	IDA		Mouse	PMID:9832509
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata6	IGI	MGI:MGI:108067	Mouse	PMID:16510470
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata6	IMP		Rat	PMID:15591218|RGD:2314197
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	gata6	IGI	ZFIN:ZDB-MRPHLNO-050927-1,ZFIN:ZDB-MRPHLNO-060522-2,ZFIN:ZDB-MRPHLNO-110124-1	Zfish	PMID:19441085
Biological Process	GO:1901390	positive regulation of transforming growth factor beta activation	GATA6	IDA		Human	PMID:33082341
Biological Process	GO:0002759	regulation of antimicrobial humoral response	GATA6	IDA		Human	PMID:33082341
Biological Process	GO:0006355	regulation of DNA-templated transcription	gata6	IDA		Zfish	PMID:24823378
Biological Process	GO:0010468	regulation of gene expression	Gata6	IGI	MGI:MGI:95664	Mouse	PMID:18400219
Biological Process	GO:0051591	response to cAMP	Gata6	IEP		Rat	PMID:9188781|RGD:2314199
Biological Process	GO:0043627	response to estrogen	Gata6	IDA		Mouse	PMID:9231805
Biological Process	GO:0070848	response to growth factor	GATA6	IDA		Human	PMID:21127043
Biological Process	GO:0032526	response to retinoic acid	GATA6	IDA		Human	PMID:33082341
Biological Process	GO:0009636	response to toxic substance	Gata6	IEP		Rat	PMID:9188781|RGD:2314199
Biological Process	GO:0009410	response to xenobiotic stimulus	GATA6	IMP		Human	PMID:18671946
Biological Process	GO:0009410	response to xenobiotic stimulus	Gata6	IEP		Rat	PMID:19842842|RGD:2314194
Biological Process	GO:0001949	sebaceous gland cell differentiation	GATA6	IDA		Human	PMID:33082341
Biological Process	GO:0003163	sinoatrial node development	Gata6	IMP	MGI:MGI:2177784	Mouse	PMID:33443158
Biological Process	GO:0098773	skin epidermis development	GATA6	IDA		Human	PMID:33082341
Biological Process	GO:0051145	smooth muscle cell differentiation	GATA6	IMP		Human	PMID:17626241
Biological Process	GO:0048863	stem cell differentiation	Gata6	IGI	MGI:MGI:95664	Mouse	PMID:18400219
Biological Process	GO:0048863	stem cell differentiation	Gata6	IMP	MGI:MGI:3793425	Mouse	PMID:18400219
Biological Process	GO:0035239	tube morphogenesis	Gata6	IGI	MGI:MGI:95664	Mouse	PMID:18400219
Biological Process	GO:0003309	type B pancreatic cell differentiation	Gata6	IMP		Mouse	PMID:16887115
Biological Process	GO:0060510	type II pneumocyte differentiation	Gata6	IGI	MGI:MGI:108067	Mouse	PMID:17164424

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern