Gata6
Gene Detail

Symbol Name ID

Gata6 GATA binding protein 6 MGI:107516

Feature Type

protein coding gene

Genetic Map

Chromosome 18

5.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr18:11052510-11085635 bp, + strand From NCBI annotation of GRCm38   33126 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68449  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor GATA-4/5/6 types
Gene Tree: Gata6

Human homologs

Human Homolog		GATA6, GATA binding protein 6
NCBI Gene ID		2627
neXtProt AC		NX_Q92908
Human Chr (Location)		18q11.1-q11.2; chr18:19749404-19782491 (+)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human GATA6

Alleles and phenotypes

All alleles(13) : Targeted(11) Gene trapped(2)
 

Homozygous null mutant E5.5 embryos lack parts of the visceral endoderm, show impaired embryonic ectoderm development, and die soon post-implantation, apparently of extraembryonic tissue defects.

 

Gene Ontology (GO) classifications

All GO classifications: (80 annotations)

Process	cardiac muscle cell differentiation, cardiac muscle hypertrophy in response to stress, ...
Component	nucleus, transcription factor complex
Function	chromatin binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (116 records)
Data Summary: Results (333)    Tissues (165)    Images (66)
Theiler Stages: 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15, 17, 18, 19, 20, 21, 23, 26, 28

Assay Type	Results
Immunohistochemistry	20
RNA in situ	240
Northern blot	13
RT-PCR	60

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) cDNA(23) Primer pair(6) Other(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000005836 (Evidence)
Entrez Gene	14465 (Evidence)
DFCI	TC1586257, TC1616140, TC1618133, TC1619484, TC1647652, TC1726393
Consensus CDS Project	CCDS29059.1
International Mouse Knockout Project Status	Gata6

Sequences

Length	Strain/Species
genomic	14465	NCBI Gene Model | MGI Sequence Detail	33126	C57BL/6J
transcript	NM_010258	RefSeq | MGI Sequence Detail	3194	C57BL/6
polypeptide	Q61169	UniProt | EBI | MGI Sequence Detail	589	Not Applicable

All sequences(29) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs within 2kb(165 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR008013	GATA-type transcription activator, N-terminal
InterPro	IPR000679	Zinc finger, GATA-type
InterPro	IPR013088	Zinc finger, NHR/GATA-type
Protein Ontology	PR:000007861	transcription factor GATA-6

Graphical View of Protein Domain Structure

References

(Earliest) J:34197 Morrisey EE, et al., GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev Biol. 1996 Jul 10;177(1):309-22
(Latest) J:191565 Grote P, et al., The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse. Dev Cell. 2013 Jan 28;24(2):206-14
All references(174)

Other accession IDs

MGD-MRK-36086, MGI:2147171