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Gata6
Gene Detail
 Symbol
Name
ID
Gata6
GATA binding protein 6
MGI:107516
Feature Type protein coding gene
Genetic Map
Chromosome 18
5.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:11052510-11085635 bp, + strand
From NCBI annotation of GRCm38

  33126 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68449  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor GATA-4/5/6 types
Gene Tree: Gata6

Human
homologs
Human Homolog GATA6, GATA binding protein 6
NCBI Gene ID 2627
neXtProt AC  NX_Q92908
Human Chr (Location)  18q11.1-q11.2; chr18:22169443-22202528 (+)  GRCh38
Disease Associations  (5) Diseases Associated with Human GATA6
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(2) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutant E5.5 embryos lack parts of the visceral endoderm, show impaired embryonic ectoderm development, and die soon post-implantation, apparently of extraembryonic tissue defects.
 
Interactions
Gata6 interacts with 208 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (82 annotations)
Process cardiac muscle cell differentiation, cardiac muscle hypertrophy in response to stress, ...
Component nucleus, transcription factor complex
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (130 records)
Data Summary: Results (362)    Tissues (189)    Images (85)
Theiler Stages: 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 23, 26, 27, 28
Assay TypeResults
Immunohistochemistry 20
RNA in situ 239
In situ reporter (knock in) 37
Northern blot 13
RT-PCR 53
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) cDNA(47) Primer pair(6) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000005836 (Evidence)
Entrez Gene14465 (Evidence)
UniGene329287
Consensus CDS ProjectCCDS29059.1
International Mouse Knockout Project StatusGata6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14465 NCBI Gene Model | MGI Sequence Detail 33126 C57BL/6J ±  kb
transcript NM_010258 RefSeq | MGI Sequence Detail 3194 C57BL/6 
polypeptide Q61169 UniProt | EBI | MGI Sequence Detail 589 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(14) UniProt(1)
Polymorphisms RFLP(2) : SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008013 GATA-type transcription activator, N-terminal
InterPro IPR000679 Zinc finger, GATA-type
InterPro IPR013088 Zinc finger, NHR/GATA-type
Protein Ontology PR:000007861 transcription factor GATA-6
Graphical View of Protein Domain Structure
References (Earliest) J:34197 Morrisey EE, et al., GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev Biol. 1996 Jul 10;177(1):309-22
(Latest) J:211301 Rosas M, et al., The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science. 2014 May 9;344(6184):645-8
All references(198)
Other
accession IDs
MGD-MRK-36086, MGI:2147171

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory