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Gata6 Gene Detail
Summary
  • Symbol
    Gata6
  • Name
    GATA binding protein 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:107516
    NCBI Gene: 14465
  • Gene Overview
    MyGene.info: GATA6
Location & Maps
more
  • Sequence Map
    Chr18:11052510-11085635 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33126 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 5.63 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GATA6, GATA binding protein 6
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GATA6, GATA binding protein 6
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 2627
    neXtProt AC: NX_Q92908

  • Chr Location
    18q11.1-q11.2; chr18:22169437-22202528 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    5 with human GATA6 associations

Human Disease Mouse Models
       Atrial Septal Defect 9; ASD9   OMIM: 614475
Atrioventricular Septal Defect 5; AVSD5   OMIM: 614474
Conotruncal Heart Malformations; CTHM   OMIM: 217095
Heart Defects, Congenital, and Other Congenital Anomalies; HDCA   OMIM: 600001
Tetralogy of Fallot; TOF   OMIM: 187500
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 10 alleles in 11 genetic backgrounds
    41 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    2
  • Targeted
    12
  • Transgenic
    2
  • Incidental Mutations
Homozygous null mutant E5.5 embryos lack parts of the visceral endoderm, show impaired embryonic ectoderm development, and die soon post-implantation, apparently of extraembryonic tissue defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005836 Ensembl Gene Model | MGI Sequence Detail 33126 C57BL/6J ±  kb
transcript ENSMUST00000047762 Ensembl | MGI Sequence Detail 3194 Not Applicable  
polypeptide ENSMUSP00000041774 Ensembl | MGI Sequence Detail 589 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    180 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007861 transcription factor GATA-6
  • InterPro Domains
    IPR008013 GATA-type transcription activator, N-terminal
    IPR028437 Transcription factor GATA-6
    IPR000679 Zinc finger, GATA-type
    IPR013088 Zinc finger, NHR/GATA-type
Molecular
Reagents
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  • All nucleic 59
    cDNA 49
    Primer pair 8
    Other 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-36086, MGI:2147171
References
more
  • Summaries
    All 231
    Developmental Gene Expression 158
    Gene Ontology 35
    Phenotypes 50
  • Earliest
    J:34197 Morrisey EE, et al., GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev Biol. 1996 Jul 10;177(1):309-22
  • Latest
    J:229891 Xuan S, et al., GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling. Development. 2016 Mar 1;143(5):780-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory