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Gene Ontology Browser
Term Detail
GO term:stem cell differentiation
GO id:GO:0048863
Definition:The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
Number of paths to term: 4

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aanther wall tapetum cell differentiation +
                                                is-aantipodal cell differentiation +
                                                is-abundle sheath cell differentiation
                                                is-acardiocyte differentiation +
                                                part-ofcell development +
                                                is-acell differentiation in hindbrain +
                                                is-acell differentiation in spinal cord +
                                                is-acell differentiation involved in embryonic placenta development +
                                                is-acell differentiation involved in kidney development +
                                                is-acell differentiation involved in salivary gland development +
                                                is-acell differentiation involved in spore germination
                                                part-ofcell fate commitment +
                                                is-achondroblast differentiation
                                                is-achondrocyte differentiation +
                                                is-achorionic trophoblast cell differentiation +
                                                is-acollenchyma cell differentiation
                                                is-acompound eye cone cell differentiation +
                                                is-acorticotropin hormone secreting cell differentiation +
                                                is-aectodermal cell differentiation +
                                                is-aembryo sac central cell differentiation +
                                                is-aembryo sac egg cell differentiation +
                                                is-aendodermal cell differentiation +
                                                is-aepithelial cell differentiation +
                                                is-afat cell differentiation +
                                                is-afoam cell differentiation +
                                                is-afollicular dendritic cell differentiation
                                                part-ofG1 to G0 transition involved in cell differentiation
                                                is-agenerative cell differentiation
                                                is-aglial cell differentiation +
                                                is-aguard cell differentiation +
                                                is-aguard mother cell differentiation
                                                is-ahematopoietic progenitor cell differentiation +
                                                is-ahemocyte differentiation +
                                                is-ahepatic stellate cell differentiation
                                                is-aheterocyst differentiation
                                                is-ahypothalamus cell differentiation +
                                                is-ainner cell mass cell differentiation +
                                                is-aleukocyte differentiation +
                                                is-aLeydig cell differentiation
                                                is-alung cell differentiation +
                                                is-aMalpighian tubule tip cell differentiation
                                                is-amesodermal cell differentiation +
                                                is-amicrosporocyte differentiation
                                                is-amuscle cell differentiation +
                                                is-amyeloid cell differentiation +
                                                is-amyofibroblast differentiation
                                                is-amystery cell differentiation
                                                negatively-regulatesnegative regulation of cell differentiation +
                                                is-aneurogenesis +
                                                is-aneuromast mantle cell differentiation +
                                                is-aneuromast support cell differentiation +
                                                is-aneuron differentiation +
                                                is-anotochord cell differentiation +
                                                is-aoenocyte differentiation +
                                                is-aoocyte differentiation +
                                                is-aosteoblast differentiation +
                                                is-apancreatic epsilon cell differentiation +
                                                is-apigment cell differentiation +
                                                is-apigment cell precursor differentiation
                                                is-aplant parenchymal cell differentiation +
                                                is-apollen sperm cell differentiation
                                                positively-regulatespositive regulation of cell differentiation +
                                                is-aprolactin secreting cell differentiation +
                                                regulatesregulation of cell differentiation +
                                                is-arenal filtration cell differentiation +
                                                is-arhombomere cell differentiation
                                                is-aroot epidermal cell differentiation +
                                                is-asclerenchyma cell differentiation
                                                is-asepal giant cell differentiation +
                                                is-asieve element differentiation +
                                                is-askeletal muscle cell differentiation +
                                                is-asocket cell differentiation
                                                is-asomatotropin secreting cell differentiation +
                                                is-asorocarp spore cell differentiation +
                                                is-aspermatid differentiation +
                                                is-asporocyte differentiation +
                                                is-asporulation resulting in formation of a cellular spore +
                                                is-astem cell differentiation [GO:0048863] (336 genes, 496 annotations)
                                                        is-acardioblast differentiation +
                                                        is-ahematopoietic stem cell differentiation +
                                                        is-ahepatoblast differentiation
                                                        is-alimb basal epidermal cell differentiation +
                                                        is-amesenchymal cell differentiation +
                                                        is-amesenchymal stem cell differentiation +
                                                        negatively-regulatesnegative regulation of stem cell differentiation +
                                                        is-aneuroblast differentiation +
                                                        positively-regulatespositive regulation of stem cell differentiation +
                                                        regulatesregulation of stem cell differentiation +
                                                        is-arespiratory basal cell differentiation
                                                        part-ofstem cell development +
                                                        part-ofstem cell fate commitment +
                                                is-asynergid differentiation +
                                                is-atendon cell differentiation +
                                                is-atransdifferentiation
                                                is-atrichome differentiation +
                                                is-atrophectodermal cell differentiation +
                                                is-avasculogenesis +
                                                is-avegetative cell differentiation
                                                is-axylem vessel member cell differentiation


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aanther wall tapetum cell differentiation +
                                                is-aantipodal cell differentiation +
                                                is-abundle sheath cell differentiation
                                                is-acardiocyte differentiation +
                                                part-ofcell development +
                                                is-acell differentiation in hindbrain +
                                                is-acell differentiation in spinal cord +
                                                is-acell differentiation involved in embryonic placenta development +
                                                is-acell differentiation involved in kidney development +
                                                is-acell differentiation involved in salivary gland development +
                                                is-acell differentiation involved in spore germination
                                                part-ofcell fate commitment +
                                                is-achondroblast differentiation
                                                is-achondrocyte differentiation +
                                                is-achorionic trophoblast cell differentiation +
                                                is-acollenchyma cell differentiation
                                                is-acompound eye cone cell differentiation +
                                                is-acorticotropin hormone secreting cell differentiation +
                                                is-aectodermal cell differentiation +
                                                is-aembryo sac central cell differentiation +
                                                is-aembryo sac egg cell differentiation +
                                                is-aendodermal cell differentiation +
                                                is-aepithelial cell differentiation +
                                                is-afat cell differentiation +
                                                is-afoam cell differentiation +
                                                is-afollicular dendritic cell differentiation
                                                part-ofG1 to G0 transition involved in cell differentiation
                                                is-agenerative cell differentiation
                                                is-aglial cell differentiation +
                                                is-aguard cell differentiation +
                                                is-aguard mother cell differentiation
                                                is-ahematopoietic progenitor cell differentiation +
                                                is-ahemocyte differentiation +
                                                is-ahepatic stellate cell differentiation
                                                is-aheterocyst differentiation
                                                is-ahypothalamus cell differentiation +
                                                is-ainner cell mass cell differentiation +
                                                is-aleukocyte differentiation +
                                                is-aLeydig cell differentiation
                                                is-alung cell differentiation +
                                                is-aMalpighian tubule tip cell differentiation
                                                is-amesodermal cell differentiation +
                                                is-amicrosporocyte differentiation
                                                is-amuscle cell differentiation +
                                                is-amyeloid cell differentiation +
                                                is-amyofibroblast differentiation
                                                is-amystery cell differentiation
                                                negatively-regulatesnegative regulation of cell differentiation +
                                                is-aneurogenesis +
                                                is-aneuromast mantle cell differentiation +
                                                is-aneuromast support cell differentiation +
                                                is-aneuron differentiation +
                                                is-anotochord cell differentiation +
                                                is-aoenocyte differentiation +
                                                is-aoocyte differentiation +
                                                is-aosteoblast differentiation +
                                                is-apancreatic epsilon cell differentiation +
                                                is-apigment cell differentiation +
                                                is-apigment cell precursor differentiation
                                                is-aplant parenchymal cell differentiation +
                                                is-apollen sperm cell differentiation
                                                positively-regulatespositive regulation of cell differentiation +
                                                is-aprolactin secreting cell differentiation +
                                                regulatesregulation of cell differentiation +
                                                is-arenal filtration cell differentiation +
                                                is-arhombomere cell differentiation
                                                is-aroot epidermal cell differentiation +
                                                is-asclerenchyma cell differentiation
                                                is-asepal giant cell differentiation +
                                                is-asieve element differentiation +
                                                is-askeletal muscle cell differentiation +
                                                is-asocket cell differentiation
                                                is-asomatotropin secreting cell differentiation +
                                                is-asorocarp spore cell differentiation +
                                                is-aspermatid differentiation +
                                                is-asporocyte differentiation +
                                                is-asporulation resulting in formation of a cellular spore +
                                                is-astem cell differentiation [GO:0048863] (336 genes, 496 annotations)
                                                        is-acardioblast differentiation +
                                                        is-ahematopoietic stem cell differentiation +
                                                        is-ahepatoblast differentiation
                                                        is-alimb basal epidermal cell differentiation +
                                                        is-amesenchymal cell differentiation +
                                                        is-amesenchymal stem cell differentiation +
                                                        negatively-regulatesnegative regulation of stem cell differentiation +
                                                        is-aneuroblast differentiation +
                                                        positively-regulatespositive regulation of stem cell differentiation +
                                                        regulatesregulation of stem cell differentiation +
                                                        is-arespiratory basal cell differentiation
                                                        part-ofstem cell development +
                                                        part-ofstem cell fate commitment +
                                                is-asynergid differentiation +
                                                is-atendon cell differentiation +
                                                is-atransdifferentiation
                                                is-atrichome differentiation +
                                                is-atrophectodermal cell differentiation +
                                                is-avasculogenesis +
                                                is-avegetative cell differentiation
                                                is-axylem vessel member cell differentiation


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aanther wall tapetum cell differentiation +
                                                is-aantipodal cell differentiation +
                                                is-abundle sheath cell differentiation
                                                is-acardiocyte differentiation +
                                                part-ofcell development +
                                                is-acell differentiation in hindbrain +
                                                is-acell differentiation in spinal cord +
                                                is-acell differentiation involved in embryonic placenta development +
                                                is-acell differentiation involved in kidney development +
                                                is-acell differentiation involved in salivary gland development +
                                                is-acell differentiation involved in spore germination
                                                part-ofcell fate commitment +
                                                is-achondroblast differentiation
                                                is-achondrocyte differentiation +
                                                is-achorionic trophoblast cell differentiation +
                                                is-acollenchyma cell differentiation
                                                is-acompound eye cone cell differentiation +
                                                is-acorticotropin hormone secreting cell differentiation +
                                                is-aectodermal cell differentiation +
                                                is-aembryo sac central cell differentiation +
                                                is-aembryo sac egg cell differentiation +
                                                is-aendodermal cell differentiation +
                                                is-aepithelial cell differentiation +
                                                is-afat cell differentiation +
                                                is-afoam cell differentiation +
                                                is-afollicular dendritic cell differentiation
                                                part-ofG1 to G0 transition involved in cell differentiation
                                                is-agenerative cell differentiation
                                                is-aglial cell differentiation +
                                                is-aguard cell differentiation +
                                                is-aguard mother cell differentiation
                                                is-ahematopoietic progenitor cell differentiation +
                                                is-ahemocyte differentiation +
                                                is-ahepatic stellate cell differentiation
                                                is-aheterocyst differentiation
                                                is-ahypothalamus cell differentiation +
                                                is-ainner cell mass cell differentiation +
                                                is-aleukocyte differentiation +
                                                is-aLeydig cell differentiation
                                                is-alung cell differentiation +
                                                is-aMalpighian tubule tip cell differentiation
                                                is-amesodermal cell differentiation +
                                                is-amicrosporocyte differentiation
                                                is-amuscle cell differentiation +
                                                is-amyeloid cell differentiation +
                                                is-amyofibroblast differentiation
                                                is-amystery cell differentiation
                                                negatively-regulatesnegative regulation of cell differentiation +
                                                is-aneurogenesis +
                                                is-aneuromast mantle cell differentiation +
                                                is-aneuromast support cell differentiation +
                                                is-aneuron differentiation +
                                                is-anotochord cell differentiation +
                                                is-aoenocyte differentiation +
                                                is-aoocyte differentiation +
                                                is-aosteoblast differentiation +
                                                is-apancreatic epsilon cell differentiation +
                                                is-apigment cell differentiation +
                                                is-apigment cell precursor differentiation
                                                is-aplant parenchymal cell differentiation +
                                                is-apollen sperm cell differentiation
                                                positively-regulatespositive regulation of cell differentiation +
                                                is-aprolactin secreting cell differentiation +
                                                regulatesregulation of cell differentiation +
                                                is-arenal filtration cell differentiation +
                                                is-arhombomere cell differentiation
                                                is-aroot epidermal cell differentiation +
                                                is-asclerenchyma cell differentiation
                                                is-asepal giant cell differentiation +
                                                is-asieve element differentiation +
                                                is-askeletal muscle cell differentiation +
                                                is-asocket cell differentiation
                                                is-asomatotropin secreting cell differentiation +
                                                is-asorocarp spore cell differentiation +
                                                is-aspermatid differentiation +
                                                is-asporocyte differentiation +
                                                is-asporulation resulting in formation of a cellular spore +
                                                is-astem cell differentiation [GO:0048863] (336 genes, 496 annotations)
                                                        is-acardioblast differentiation +
                                                        is-ahematopoietic stem cell differentiation +
                                                        is-ahepatoblast differentiation
                                                        is-alimb basal epidermal cell differentiation +
                                                        is-amesenchymal cell differentiation +
                                                        is-amesenchymal stem cell differentiation +
                                                        negatively-regulatesnegative regulation of stem cell differentiation +
                                                        is-aneuroblast differentiation +
                                                        positively-regulatespositive regulation of stem cell differentiation +
                                                        regulatesregulation of stem cell differentiation +
                                                        is-arespiratory basal cell differentiation
                                                        part-ofstem cell development +
                                                        part-ofstem cell fate commitment +
                                                is-asynergid differentiation +
                                                is-atendon cell differentiation +
                                                is-atransdifferentiation
                                                is-atrichome differentiation +
                                                is-atrophectodermal cell differentiation +
                                                is-avasculogenesis +
                                                is-avegetative cell differentiation
                                                is-axylem vessel member cell differentiation


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-aanther wall tapetum cell differentiation +
                                                is-aantipodal cell differentiation +
                                                is-abundle sheath cell differentiation
                                                is-acardiocyte differentiation +
                                                part-ofcell development +
                                                is-acell differentiation in hindbrain +
                                                is-acell differentiation in spinal cord +
                                                is-acell differentiation involved in embryonic placenta development +
                                                is-acell differentiation involved in kidney development +
                                                is-acell differentiation involved in salivary gland development +
                                                is-acell differentiation involved in spore germination
                                                part-ofcell fate commitment +
                                                is-achondroblast differentiation
                                                is-achondrocyte differentiation +
                                                is-achorionic trophoblast cell differentiation +
                                                is-acollenchyma cell differentiation
                                                is-acompound eye cone cell differentiation +
                                                is-acorticotropin hormone secreting cell differentiation +
                                                is-aectodermal cell differentiation +
                                                is-aembryo sac central cell differentiation +
                                                is-aembryo sac egg cell differentiation +
                                                is-aendodermal cell differentiation +
                                                is-aepithelial cell differentiation +
                                                is-afat cell differentiation +
                                                is-afoam cell differentiation +
                                                is-afollicular dendritic cell differentiation
                                                part-ofG1 to G0 transition involved in cell differentiation
                                                is-agenerative cell differentiation
                                                is-aglial cell differentiation +
                                                is-aguard cell differentiation +
                                                is-aguard mother cell differentiation
                                                is-ahematopoietic progenitor cell differentiation +
                                                is-ahemocyte differentiation +
                                                is-ahepatic stellate cell differentiation
                                                is-aheterocyst differentiation
                                                is-ahypothalamus cell differentiation +
                                                is-ainner cell mass cell differentiation +
                                                is-aleukocyte differentiation +
                                                is-aLeydig cell differentiation
                                                is-alung cell differentiation +
                                                is-aMalpighian tubule tip cell differentiation
                                                is-amesodermal cell differentiation +
                                                is-amicrosporocyte differentiation
                                                is-amuscle cell differentiation +
                                                is-amyeloid cell differentiation +
                                                is-amyofibroblast differentiation
                                                is-amystery cell differentiation
                                                negatively-regulatesnegative regulation of cell differentiation +
                                                is-aneurogenesis +
                                                is-aneuromast mantle cell differentiation +
                                                is-aneuromast support cell differentiation +
                                                is-aneuron differentiation +
                                                is-anotochord cell differentiation +
                                                is-aoenocyte differentiation +
                                                is-aoocyte differentiation +
                                                is-aosteoblast differentiation +
                                                is-apancreatic epsilon cell differentiation +
                                                is-apigment cell differentiation +
                                                is-apigment cell precursor differentiation
                                                is-aplant parenchymal cell differentiation +
                                                is-apollen sperm cell differentiation
                                                positively-regulatespositive regulation of cell differentiation +
                                                is-aprolactin secreting cell differentiation +
                                                regulatesregulation of cell differentiation +
                                                is-arenal filtration cell differentiation +
                                                is-arhombomere cell differentiation
                                                is-aroot epidermal cell differentiation +
                                                is-asclerenchyma cell differentiation
                                                is-asepal giant cell differentiation +
                                                is-asieve element differentiation +
                                                is-askeletal muscle cell differentiation +
                                                is-asocket cell differentiation
                                                is-asomatotropin secreting cell differentiation +
                                                is-asorocarp spore cell differentiation +
                                                is-aspermatid differentiation +
                                                is-asporocyte differentiation +
                                                is-asporulation resulting in formation of a cellular spore +
                                                is-astem cell differentiation [GO:0048863] (336 genes, 496 annotations)
                                                        is-acardioblast differentiation +
                                                        is-ahematopoietic stem cell differentiation +
                                                        is-ahepatoblast differentiation
                                                        is-alimb basal epidermal cell differentiation +
                                                        is-amesenchymal cell differentiation +
                                                        is-amesenchymal stem cell differentiation +
                                                        negatively-regulatesnegative regulation of stem cell differentiation +
                                                        is-aneuroblast differentiation +
                                                        positively-regulatespositive regulation of stem cell differentiation +
                                                        regulatesregulation of stem cell differentiation +
                                                        is-arespiratory basal cell differentiation
                                                        part-ofstem cell development +
                                                        part-ofstem cell fate commitment +
                                                is-asynergid differentiation +
                                                is-atendon cell differentiation +
                                                is-atransdifferentiation
                                                is-atrichome differentiation +
                                                is-atrophectodermal cell differentiation +
                                                is-avasculogenesis +
                                                is-avegetative cell differentiation
                                                is-axylem vessel member cell differentiation


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory