| GO term: | cellular response to hypoxia |
| Synonym: | cellular response to hypoxic stress |
| Synonym: | cellular response to lowered oxygen tension |
| GO id: | GO:0071456 |
| Definition: | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
| Comments | Note that this term should not be confused with 'cellular response to anoxia ; GO:0071454'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. |
| Number of paths to term: | 12 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular processsingle-organism cellular processcellular response to stimuluscellular response to chemical stimuluscellular response to oxygen levelscellular response to decreased oxygen levelscellular response to anoxiacellular response to hypoxia [GO:0071456] (40 genes, 44 annotations)hypoxia-inducible factor-1alpha signaling pathway +negative regulation of cellular response to hypoxia +positive regulation of cellular response to hypoxia +positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxiaregulation of cellular response to hypoxia +regulation of transcription from RNA polymerase II promoter in response to hypoxia +positive regulation of SREBP signaling pathway in response to decreased oxygen levels +biological_processcellular processsingle-organism cellular processcellular response to stimuluscellular response to stresscellular detoxification of nitrogen compoundcellular response to anoxiacellular response to cold +cellular response to fluid shear stress +cellular response to heat +cellular response to hydrostatic pressure +cellular response to hyperoxiacellular response to hypoxia [GO:0071456] (40 genes, 44 annotations)hypoxia-inducible factor-1alpha signaling pathway +negative regulation of cellular response to hypoxia +positive regulation of cellular response to hypoxia +positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxiaregulation of cellular response to hypoxia +regulation of transcription from RNA polymerase II promoter in response to hypoxia +cellular response to immobilization stresscellular response to isolation stresscellular response to nitrosative stress +cellular response to osmotic stress +cellular response to oxidative stress +cellular response to starvation +cellular response to sterol depletion +cellular response to topologically incorrect protein +cellular response to water deprivation +cellular senescence +defense response by cell wall thickening +DNA protectionintracellular defense responsenegative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stressneuron projection regeneration +plant-type hypersensitive response +priming of cellular response to stressregulation of cellular response to stress +regulation of DNA-dependent transcription in response to stress +regulation of mRNA stability involved in response to stress +regulation of translation in response to stress +response to DNA damage stimulus +response to endoplasmic reticulum stress +SOS responsestress-activated protein kinase signaling cascade +stress-induced mitochondrial fusiontrehalose metabolism in response to stress +biological_processresponse to stimuluscellular response to stimuluscellular response to chemical stimuluscellular response to oxygen levelscellular response to decreased oxygen levelscellular response to anoxiacellular response to hypoxia [GO:0071456] (40 genes, 44 annotations)hypoxia-inducible factor-1alpha signaling pathway +negative regulation of cellular response to hypoxia +positive regulation of cellular response to hypoxia +positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxiaregulation of cellular response to hypoxia +regulation of transcription from RNA polymerase II promoter in response to hypoxia +positive regulation of SREBP signaling pathway in response to decreased oxygen levels +biological_processresponse to stimuluscellular response to stimuluscellular response to stresscellular detoxification of nitrogen compoundcellular response to anoxiacellular response to cold +cellular response to fluid shear stress +cellular response to heat +cellular response to hydrostatic pressure +cellular response to hyperoxiacellular response to hypoxia [GO:0071456] (40 genes, 44 annotations)hypoxia-inducible factor-1alpha signaling pathway +negative regulation of cellular response to hypoxia +positive regulation of cellular response to hypoxia +positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxiaregulation of cellular response to hypoxia +regulation of transcription from RNA polymerase II promoter in response to hypoxia +cellular response to immobilization stresscellular response to isolation stresscellular response to nitrosative stress +cellular response to osmotic stress +cellular response to oxidative stress +cellular response to starvation +cellular response to sterol depletion +cellular response to topologically incorrect protein +cellular response to water deprivation +cellular senescence +defense response by cell wall thickening +DNA protectionintracellular defense responsenegative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stressneuron projection regeneration +plant-type hypersensitive response +priming of cellular response to stressregulation of cellular response to stress +regulation of DNA-dependent transcription in response to stress +regulation of mRNA stability involved in response to stress +regulation of translation in response to stress +response to DNA damage stimulus +response to endoplasmic reticulum stress +SOS responsestress-activated protein kinase signaling cascade +stress-induced mitochondrial fusiontrehalose metabolism in response to stress +biological_processresponse to stimulusresponse to abiotic stimulusresponse to oxygen levelscellular response to oxygen levelscellular response to decreased oxygen levelscellular response to anoxiacellular response to hypoxia [GO:0071456] (40 genes, 44 annotations)hypoxia-inducible factor-1alpha signaling pathway +negative regulation of cellular response to hypoxia +positive regulation of cellular response to hypoxia +positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxiaregulation of cellular response to hypoxia +regulation of transcription from RNA polymerase II promoter in response to hypoxia +positive regulation of SREBP signaling pathway in response to decreased oxygen levels +biological_processresponse to stimulusresponse to abiotic stimulusresponse to oxygen levelsresponse to decreased oxygen levelscellular response to decreased oxygen levelscellular response to anoxiacellular response to hypoxia [GO:0071456] (40 genes, 44 annotations)hypoxia-inducible factor-1alpha signaling pathway +negative regulation of cellular response to hypoxia +positive regulation of cellular response to hypoxia +positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxiaregulation of cellular response to hypoxia +regulation of transcription from RNA polymerase II promoter in response to hypoxia +positive regulation of SREBP signaling pathway in response to decreased oxygen levels +biological_processresponse to stimulusresponse to abiotic stimulusresponse to oxygen levelsresponse to decreased oxygen levelsresponse to hypoxiacellular response to hypoxia [GO:0071456] (40 genes, 44 annotations)hypoxia-inducible factor-1alpha signaling pathway +negative regulation of cellular response to hypoxia +positive regulation of cellular response to hypoxia +positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxiaregulation of cellular response to hypoxia +regulation of transcription from RNA polymerase II promoter in response to hypoxia +detection of hypoxia +biological_processresponse to stimulusresponse to chemical stimuluscellular response to chemical stimuluscellular response to oxygen levelscellular response to decreased oxygen levelscellular response to anoxiacellular response to hypoxia [GO:0071456] (40 genes, 44 annotations)hypoxia-inducible factor-1alpha signaling pathway +negative regulation of cellular response to hypoxia +positive regulation of cellular response to hypoxia +positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxiaregulation of cellular response to hypoxia +regulation of transcription from RNA polymerase II promoter in response to hypoxia +positive regulation of SREBP signaling pathway in response to decreased oxygen levels +biological_processresponse to stimulusresponse to stresscellular response to stresscellular detoxification of nitrogen compoundcellular response to anoxiacellular response to cold +cellular response to fluid shear stress +cellular response to heat +cellular response to hydrostatic pressure +cellular response to hyperoxiacellular response to hypoxia [GO:0071456] (40 genes, 44 annotations)hypoxia-inducible factor-1alpha signaling pathway +negative regulation of cellular response to hypoxia +positive regulation of cellular response to hypoxia +positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxiaregulation of cellular response to hypoxia +regulation of transcription from RNA polymerase II promoter in response to hypoxia +cellular response to immobilization stresscellular response to isolation stresscellular response to nitrosative stress +cellular response to osmotic stress +cellular response to oxidative stress +cellular response to starvation +cellular response to sterol depletion +cellular response to topologically incorrect protein +cellular response to water deprivation +cellular senescence +defense response by cell wall thickening +DNA protectionintracellular defense responsenegative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stressneuron projection regeneration +plant-type hypersensitive response +priming of cellular response to stressregulation of cellular response to stress +regulation of DNA-dependent transcription in response to stress +regulation of mRNA stability involved in response to stress +regulation of translation in response to stress +response to DNA damage stimulus +response to endoplasmic reticulum stress +SOS responsestress-activated protein kinase signaling cascade +stress-induced mitochondrial fusiontrehalose metabolism in response to stress +biological_processresponse to stimulusresponse to stressresponse to hypoxiacellular response to hypoxia [GO:0071456] (40 genes, 44 annotations)hypoxia-inducible factor-1alpha signaling pathway +negative regulation of cellular response to hypoxia +positive regulation of cellular response to hypoxia +positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxiaregulation of cellular response to hypoxia +regulation of transcription from RNA polymerase II promoter in response to hypoxia +detection of hypoxia +biological_processsingle-organism processsingle-organism cellular processcellular response to stimuluscellular response to chemical stimuluscellular response to oxygen levelscellular response to decreased oxygen levelscellular response to anoxiacellular response to hypoxia [GO:0071456] (40 genes, 44 annotations)hypoxia-inducible factor-1alpha signaling pathway +negative regulation of cellular response to hypoxia +positive regulation of cellular response to hypoxia +positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxiaregulation of cellular response to hypoxia +regulation of transcription from RNA polymerase II promoter in response to hypoxia +positive regulation of SREBP signaling pathway in response to decreased oxygen levels +biological_processsingle-organism processsingle-organism cellular processcellular response to stimuluscellular response to stresscellular detoxification of nitrogen compoundcellular response to anoxiacellular response to cold +cellular response to fluid shear stress +cellular response to heat +cellular response to hydrostatic pressure +cellular response to hyperoxiacellular response to hypoxia [GO:0071456] (40 genes, 44 annotations)hypoxia-inducible factor-1alpha signaling pathway +negative regulation of cellular response to hypoxia +positive regulation of cellular response to hypoxia +positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxiaregulation of cellular response to hypoxia +regulation of transcription from RNA polymerase II promoter in response to hypoxia +cellular response to immobilization stresscellular response to isolation stresscellular response to nitrosative stress +cellular response to osmotic stress +cellular response to oxidative stress +cellular response to starvation +cellular response to sterol depletion +cellular response to topologically incorrect protein +cellular response to water deprivation +cellular senescence +defense response by cell wall thickening +DNA protectionintracellular defense responsenegative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stressneuron projection regeneration +plant-type hypersensitive response +priming of cellular response to stressregulation of cellular response to stress +regulation of DNA-dependent transcription in response to stress +regulation of mRNA stability involved in response to stress +regulation of translation in response to stress +response to DNA damage stimulus +response to endoplasmic reticulum stress +SOS responsestress-activated protein kinase signaling cascade +stress-induced mitochondrial fusiontrehalose metabolism in response to stress +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
||
|
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support. |
last database update 06/05/2013 MGI 5.13 |
|
|
|
||
Analysis Tools