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Term Detail
GO term:cellular response to hypoxia
Synonym: cellular response to hypoxic stress
Synonym: cellular response to lowered oxygen tension
GO id:GO:0071456
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
CommentsNote that this term should not be confused with 'cellular response to anoxia ; GO:0071454'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
Number of paths to term: 10

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to oxygen levels
                                                is-acellular response to decreased oxygen levels
                                                        is-acellular response to anoxia
                                                        is-acellular response to hypoxia [GO:0071456] (55 genes, 65 annotations)
                                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                                negatively-regulatesnegative regulation of cellular response to hypoxia +
                                                                positively-regulatespositive regulation of cellular response to hypoxia +
                                                                part-ofpositive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
                                                                regulatesregulation of cellular response to hypoxia +
                                                                is-aregulation of transcription from RNA polymerase II promoter in response to hypoxia +
                                                        is-apositive regulation of SREBP signaling pathway in response to decreased oxygen levels +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-acellular detoxification of nitrogen compound
                                        is-acellular response to anoxia
                                        is-acellular response to cell envelope stress
                                        is-acellular response to cold +
                                        is-acellular response to DNA damage stimulus +
                                        is-acellular response to fluid shear stress +
                                        is-acellular response to heat +
                                        is-acellular response to hydrostatic pressure +
                                        is-acellular response to hyperoxia
                                        is-acellular response to hypoxia [GO:0071456] (55 genes, 65 annotations)
                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                negatively-regulatesnegative regulation of cellular response to hypoxia +
                                                positively-regulatespositive regulation of cellular response to hypoxia +
                                                part-ofpositive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
                                                regulatesregulation of cellular response to hypoxia +
                                                is-aregulation of transcription from RNA polymerase II promoter in response to hypoxia +
                                        is-acellular response to immobilization stress
                                        is-acellular response to isolation stress
                                        is-acellular response to nitrosative stress +
                                        is-acellular response to osmotic stress +
                                        is-acellular response to oxidative stress +
                                        is-acellular response to starvation +
                                        is-acellular response to sterol depletion +
                                        is-acellular response to sugar-phosphate stress +
                                        is-acellular response to topologically incorrect protein +
                                        is-acellular response to water deprivation +
                                        is-acellular senescence +
                                        is-acellular stress response to acid
                                        is-acellular stress response to acidity
                                        is-adefense response by cell wall thickening +
                                        is-aDNA protection
                                        is-aintracellular defense response
                                        is-anegative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress
                                        is-aneuron projection regeneration +
                                        is-aplant-type hypersensitive response +
                                        part-ofpriming of cellular response to stress
                                        regulatesregulation of cellular response to stress +
                                        is-aregulation of DNA-templated transcription in response to stress +
                                        part-ofregulation of mRNA stability involved in response to stress +
                                        is-aregulation of translation in response to stress +
                                        is-aresponse to endoplasmic reticulum stress +
                                        is-aSOS response
                                        is-astress-activated protein kinase signaling cascade +
                                        is-astress-induced mitochondrial fusion
                                        part-oftrehalose catabolic process involved in cellular response to stress
                                        is-atrehalose metabolism in response to stress +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to oxygen levels
                                                is-acellular response to decreased oxygen levels
                                                        is-acellular response to anoxia
                                                        is-acellular response to hypoxia [GO:0071456] (55 genes, 65 annotations)
                                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                                negatively-regulatesnegative regulation of cellular response to hypoxia +
                                                                positively-regulatespositive regulation of cellular response to hypoxia +
                                                                part-ofpositive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
                                                                regulatesregulation of cellular response to hypoxia +
                                                                is-aregulation of transcription from RNA polymerase II promoter in response to hypoxia +
                                                        is-apositive regulation of SREBP signaling pathway in response to decreased oxygen levels +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-acellular detoxification of nitrogen compound
                                        is-acellular response to anoxia
                                        is-acellular response to cell envelope stress
                                        is-acellular response to cold +
                                        is-acellular response to DNA damage stimulus +
                                        is-acellular response to fluid shear stress +
                                        is-acellular response to heat +
                                        is-acellular response to hydrostatic pressure +
                                        is-acellular response to hyperoxia
                                        is-acellular response to hypoxia [GO:0071456] (55 genes, 65 annotations)
                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                negatively-regulatesnegative regulation of cellular response to hypoxia +
                                                positively-regulatespositive regulation of cellular response to hypoxia +
                                                part-ofpositive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
                                                regulatesregulation of cellular response to hypoxia +
                                                is-aregulation of transcription from RNA polymerase II promoter in response to hypoxia +
                                        is-acellular response to immobilization stress
                                        is-acellular response to isolation stress
                                        is-acellular response to nitrosative stress +
                                        is-acellular response to osmotic stress +
                                        is-acellular response to oxidative stress +
                                        is-acellular response to starvation +
                                        is-acellular response to sterol depletion +
                                        is-acellular response to sugar-phosphate stress +
                                        is-acellular response to topologically incorrect protein +
                                        is-acellular response to water deprivation +
                                        is-acellular senescence +
                                        is-acellular stress response to acid
                                        is-acellular stress response to acidity
                                        is-adefense response by cell wall thickening +
                                        is-aDNA protection
                                        is-aintracellular defense response
                                        is-anegative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress
                                        is-aneuron projection regeneration +
                                        is-aplant-type hypersensitive response +
                                        part-ofpriming of cellular response to stress
                                        regulatesregulation of cellular response to stress +
                                        is-aregulation of DNA-templated transcription in response to stress +
                                        part-ofregulation of mRNA stability involved in response to stress +
                                        is-aregulation of translation in response to stress +
                                        is-aresponse to endoplasmic reticulum stress +
                                        is-aSOS response
                                        is-astress-activated protein kinase signaling cascade +
                                        is-astress-induced mitochondrial fusion
                                        part-oftrehalose catabolic process involved in cellular response to stress
                                        is-atrehalose metabolism in response to stress +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to abiotic stimulus
                                is-aresponse to oxygen levels
                                        is-acellular response to oxygen levels
                                                is-acellular response to decreased oxygen levels
                                                        is-acellular response to anoxia
                                                        is-acellular response to hypoxia [GO:0071456] (55 genes, 65 annotations)
                                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                                negatively-regulatesnegative regulation of cellular response to hypoxia +
                                                                positively-regulatespositive regulation of cellular response to hypoxia +
                                                                part-ofpositive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
                                                                regulatesregulation of cellular response to hypoxia +
                                                                is-aregulation of transcription from RNA polymerase II promoter in response to hypoxia +
                                                        is-apositive regulation of SREBP signaling pathway in response to decreased oxygen levels +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to abiotic stimulus
                                is-aresponse to oxygen levels
                                        is-aresponse to decreased oxygen levels
                                                is-acellular response to decreased oxygen levels
                                                        is-acellular response to anoxia
                                                        is-acellular response to hypoxia [GO:0071456] (55 genes, 65 annotations)
                                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                                negatively-regulatesnegative regulation of cellular response to hypoxia +
                                                                positively-regulatespositive regulation of cellular response to hypoxia +
                                                                part-ofpositive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
                                                                regulatesregulation of cellular response to hypoxia +
                                                                is-aregulation of transcription from RNA polymerase II promoter in response to hypoxia +
                                                        is-apositive regulation of SREBP signaling pathway in response to decreased oxygen levels +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to abiotic stimulus
                                is-aresponse to oxygen levels
                                        is-aresponse to decreased oxygen levels
                                                is-aresponse to hypoxia
                                                        is-acellular response to hypoxia [GO:0071456] (55 genes, 65 annotations)
                                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                                negatively-regulatesnegative regulation of cellular response to hypoxia +
                                                                positively-regulatespositive regulation of cellular response to hypoxia +
                                                                part-ofpositive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
                                                                regulatesregulation of cellular response to hypoxia +
                                                                is-aregulation of transcription from RNA polymerase II promoter in response to hypoxia +
                                                        is-adetection of hypoxia +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-acellular response to chemical stimulus
                                        is-acellular response to oxygen levels
                                                is-acellular response to decreased oxygen levels
                                                        is-acellular response to anoxia
                                                        is-acellular response to hypoxia [GO:0071456] (55 genes, 65 annotations)
                                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                                negatively-regulatesnegative regulation of cellular response to hypoxia +
                                                                positively-regulatespositive regulation of cellular response to hypoxia +
                                                                part-ofpositive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
                                                                regulatesregulation of cellular response to hypoxia +
                                                                is-aregulation of transcription from RNA polymerase II promoter in response to hypoxia +
                                                        is-apositive regulation of SREBP signaling pathway in response to decreased oxygen levels +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-acellular response to stress
                                        is-acellular detoxification of nitrogen compound
                                        is-acellular response to anoxia
                                        is-acellular response to cell envelope stress
                                        is-acellular response to cold +
                                        is-acellular response to DNA damage stimulus +
                                        is-acellular response to fluid shear stress +
                                        is-acellular response to heat +
                                        is-acellular response to hydrostatic pressure +
                                        is-acellular response to hyperoxia
                                        is-acellular response to hypoxia [GO:0071456] (55 genes, 65 annotations)
                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                negatively-regulatesnegative regulation of cellular response to hypoxia +
                                                positively-regulatespositive regulation of cellular response to hypoxia +
                                                part-ofpositive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
                                                regulatesregulation of cellular response to hypoxia +
                                                is-aregulation of transcription from RNA polymerase II promoter in response to hypoxia +
                                        is-acellular response to immobilization stress
                                        is-acellular response to isolation stress
                                        is-acellular response to nitrosative stress +
                                        is-acellular response to osmotic stress +
                                        is-acellular response to oxidative stress +
                                        is-acellular response to starvation +
                                        is-acellular response to sterol depletion +
                                        is-acellular response to sugar-phosphate stress +
                                        is-acellular response to topologically incorrect protein +
                                        is-acellular response to water deprivation +
                                        is-acellular senescence +
                                        is-acellular stress response to acid
                                        is-acellular stress response to acidity
                                        is-adefense response by cell wall thickening +
                                        is-aDNA protection
                                        is-aintracellular defense response
                                        is-anegative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress
                                        is-aneuron projection regeneration +
                                        is-aplant-type hypersensitive response +
                                        part-ofpriming of cellular response to stress
                                        regulatesregulation of cellular response to stress +
                                        is-aregulation of DNA-templated transcription in response to stress +
                                        part-ofregulation of mRNA stability involved in response to stress +
                                        is-aregulation of translation in response to stress +
                                        is-aresponse to endoplasmic reticulum stress +
                                        is-aSOS response
                                        is-astress-activated protein kinase signaling cascade +
                                        is-astress-induced mitochondrial fusion
                                        part-oftrehalose catabolic process involved in cellular response to stress
                                        is-atrehalose metabolism in response to stress +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-aresponse to hypoxia
                                        is-acellular response to hypoxia [GO:0071456] (55 genes, 65 annotations)
                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                negatively-regulatesnegative regulation of cellular response to hypoxia +
                                                positively-regulatespositive regulation of cellular response to hypoxia +
                                                part-ofpositive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
                                                regulatesregulation of cellular response to hypoxia +
                                                is-aregulation of transcription from RNA polymerase II promoter in response to hypoxia +
                                        is-adetection of hypoxia +


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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory