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Gene Ontology Browser
Term Detail
GO term:RNA polymerase II core promoter proximal region sequence-specific DNA binding
Synonym: RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding
GO id:GO:0000978
Definition:Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
CommentsNote that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to regulatory sequences that occur in the region upstream and proximal to the core promoter. In contrast, in bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is a synonym for "enhancer".
Number of paths to term: 20

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-acore promoter proximal region DNA binding
                                                                        is-acore promoter proximal region sequence-specific DNA binding
                                                                                is-abacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                                is-amitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                                is-aRNA polymerase I upstream control element sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-aRNA polymerase II regulatory region DNA binding
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                                is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-atranscription regulatory region sequence-specific DNA binding
                                                                        is-acore promoter proximal region sequence-specific DNA binding
                                                                                is-abacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                                is-amitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                                is-aRNA polymerase I upstream control element sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-atranscription regulatory region sequence-specific DNA binding
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                                is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-asequence-specific DNA binding
                                                        is-atranscription regulatory region sequence-specific DNA binding
                                                                is-acore promoter proximal region sequence-specific DNA binding
                                                                        is-abacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                        is-amitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                        is-aRNA polymerase I upstream control element sequence-specific DNA binding
                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-asequence-specific DNA binding
                                                        is-atranscription regulatory region sequence-specific DNA binding
                                                                is-aRNA polymerase II regulatory region sequence-specific DNA binding
                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending
                                                                        is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                        is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                        is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-acore promoter proximal region DNA binding
                                                                        is-acore promoter proximal region sequence-specific DNA binding
                                                                                is-abacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                                is-amitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                                is-aRNA polymerase I upstream control element sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-aRNA polymerase II regulatory region DNA binding
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                                is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-atranscription regulatory region sequence-specific DNA binding
                                                                        is-acore promoter proximal region sequence-specific DNA binding
                                                                                is-abacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                                is-amitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                                is-aRNA polymerase I upstream control element sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-atranscription regulatory region sequence-specific DNA binding
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                                is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-acore promoter proximal region DNA binding
                                                                        is-acore promoter proximal region sequence-specific DNA binding
                                                                                is-abacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                                is-amitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                                is-aRNA polymerase I upstream control element sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-aRNA polymerase II regulatory region DNA binding
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                                is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-atranscription regulatory region sequence-specific DNA binding
                                                                        is-acore promoter proximal region sequence-specific DNA binding
                                                                                is-abacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                                is-amitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                                is-aRNA polymerase I upstream control element sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-atranscription regulatory region sequence-specific DNA binding
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                                is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-asequence-specific DNA binding
                                                        is-atranscription regulatory region sequence-specific DNA binding
                                                                is-acore promoter proximal region sequence-specific DNA binding
                                                                        is-abacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                        is-amitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                        is-aRNA polymerase I upstream control element sequence-specific DNA binding
                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-asequence-specific DNA binding
                                                        is-atranscription regulatory region sequence-specific DNA binding
                                                                is-aRNA polymerase II regulatory region sequence-specific DNA binding
                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending
                                                                        is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                        is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                        is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-acore promoter proximal region DNA binding
                                                                        is-acore promoter proximal region sequence-specific DNA binding
                                                                                is-abacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                                is-amitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                                is-aRNA polymerase I upstream control element sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-aRNA polymerase II regulatory region DNA binding
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                                is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-atranscription regulatory region sequence-specific DNA binding
                                                                        is-acore promoter proximal region sequence-specific DNA binding
                                                                                is-abacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                                is-amitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
                                                                                is-aRNA polymerase I upstream control element sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-atranscription regulatory region sequence-specific DNA binding
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978] (187 genes, 198 annotations)
                                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding, bending
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                                is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding


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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory