Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Flcn

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes FLCN
- Mouse genes Flcn
- Rat genes Flcn
- Zfish genes flcn
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Flcn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	FLCN	IPI	UniProtKB:P00338	Human	PMID:34381247
Molecular Function	GO:0004857	enzyme inhibitor activity	FLCN	IDA		Human	PMID:34381247
Molecular Function	GO:0005096	GTPase activator activity	FLCN	IDA		Human	PMID:24095279
Molecular Function	GO:0005096	GTPase activator activity	FLCN	IDA		Human	PMID:31672913
Molecular Function	GO:0005096	GTPase activator activity	FLCN	IDA		Human	PMID:31704029
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:Q8TF40	Human	PMID:17028174
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:Q8TF40	Human	PMID:18403135
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:Q9P278	Human	PMID:18403135
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:Q9P278	Human	PMID:18663353
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:Q99569	Human	PMID:22965878
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:O75385	Human	PMID:25126726
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:O95166	Human	PMID:25126726
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:O95166,UniProtKB:Q8TF40	Human	PMID:25126726
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:O95166,UniProtKB:Q9P278	Human	PMID:25126726
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:Q96NA2	Human	PMID:27113757
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:O95433	Human	PMID:27353360
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:P07900	Human	PMID:27353360
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:P31948	Human	PMID:27353360
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:P53041	Human	PMID:27353360
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:P78371	Human	PMID:27353360
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:Q15185	Human	PMID:27353360
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:Q16543	Human	PMID:27353360
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:Q8TF40	Human	PMID:27353360
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:Q9P278	Human	PMID:27353360
Molecular Function	GO:0005515	protein binding	FLCN	IPI	UniProtKB:Q9UNE7	Human	PMID:27353360
Molecular Function	GO:0005515	protein binding	Flcn	IPI	UniProtKB:Q68FD7	Mouse	MGI:MGI:5512921\|PMID:23582324
Molecular Function	GO:0005515	protein binding	Flcn	IPI	UniProtKB:P54645	Rat	PMID:19914239\|RGD:8553849
Molecular Function	GO:0005515	protein binding	Flcn	IPI	UniProtKB:Q13131	Rat	PMID:19914239\|RGD:8553849
Molecular Function	GO:0005515	protein binding	Flcn	IPI	UniProtKB:Q8TF40	Rat	PMID:19914239\|RGD:8553849
Molecular Function	GO:0005515	protein binding	Flcn	IPI	UniProtKB:Q9P278	Rat	PMID:19914239\|RGD:8553849
Molecular Function	GO:0044877	protein-containing complex binding	FLCN	IDA		Human	PMID:17028174
Cellular Component	GO:0044291	cell-cell contact zone	FLCN	IDA		Human	PMID:22965878
Cellular Component	GO:0005813	centrosome	FLCN	IDA		Human	PMID:23784378
Cellular Component	GO:0005929	cilium	FLCN	IDA		Human	PMID:23784378
Cellular Component	GO:0005737	cytoplasm	FLCN	IDA		Human	PMID:17028174
Cellular Component	GO:0005737	cytoplasm	FLCN	IDA		Human	PMID:18663353
Cellular Component	GO:0005737	cytoplasm	FLCN	IDA		Human	PMID:22965878
Cellular Component	GO:0005829	cytosol	FLCN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	FLCN	IDA		Human	PMID:24081491
Cellular Component	GO:0005829	cytosol	FLCN	IDA		Human	PMID:24095279
Cellular Component	GO:0005829	cytosol	FLCN	IDA		Human	PMID:29848618
Cellular Component	GO:0005829	cytosol	FLCN	IDA		Human	PMID:31672913
Cellular Component	GO:0005765	lysosomal membrane	FLCN	IDA		Human	PMID:24081491
Cellular Component	GO:0005765	lysosomal membrane	FLCN	IDA		Human	PMID:24095279
Cellular Component	GO:0005765	lysosomal membrane	FLCN	IDA		Human	PMID:27113757
Cellular Component	GO:0005765	lysosomal membrane	FLCN	IDA		Human	PMID:29848618
Cellular Component	GO:0005765	lysosomal membrane	FLCN	IDA		Human	PMID:31672913
Cellular Component	GO:0030496	midbody	FLCN	IDA		Human	PMID:22965878
Cellular Component	GO:0072686	mitotic spindle	FLCN	IDA		Human	PMID:23784378
Cellular Component	GO:0005634	nucleus	FLCN	IDA		Human	PMID:17028174
Cellular Component	GO:0005634	nucleus	FLCN	IDA		Human	PMID:18663353
Cellular Component	GO:0005886	plasma membrane	FLCN	IDA		Human	GO_REF:0000052
Biological Process	GO:0072111	cell proliferation involved in kidney development	Flcn	IMP	MGI:MGI:3829641	Mouse	PMID:18974783
Biological Process	GO:0072111	cell proliferation involved in kidney development	Flcn	IMP	MGI:MGI:3842151	Mouse	PMID:19843504
Biological Process	GO:0072111	cell proliferation involved in kidney development	Flcn	IMP	MGI:MGI:3774414	Mouse	PMID:18182616
Biological Process	GO:0072111	cell proliferation involved in kidney development	Flcn	IMP	MGI:MGI:3774416	Mouse	PMID:19850877
Biological Process	GO:0007043	cell-cell junction assembly	Flcn	IMP		Mouse	MGI:MGI:5487492\|PMID:22965878
Biological Process	GO:0034198	cellular response to amino acid starvation	FLCN	IDA		Human	PMID:24095279
Biological Process	GO:0034198	cellular response to amino acid starvation	FLCN	IDA		Human	PMID:27113757
Biological Process	GO:0034198	cellular response to amino acid starvation	FLCN	IDA		Human	PMID:31672913
Biological Process	GO:0009267	cellular response to starvation	FLCN	IDA		Human	PMID:24095279
Biological Process	GO:0009267	cellular response to starvation	FLCN	IDA		Human	PMID:31672913
Biological Process	GO:0097009	energy homeostasis	Flcn	IMP		Mouse	MGI:MGI:5463828\|PMID:23150719
Biological Process	GO:0050673	epithelial cell proliferation	Flcn	IMP	MGI:MGI:3842151	Mouse	PMID:19843504
Biological Process	GO:0050673	epithelial cell proliferation	Flcn	IMP	MGI:MGI:3774414	Mouse	PMID:18182616
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Flcn	IMP	MGI:MGI:4348628	Mouse	PMID:21258407
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Flcn	IMP	MGI:MGI:3774414	Mouse	PMID:18182616
Biological Process	GO:0030097	hemopoiesis	Flcn	IMP	MGI:MGI:4348628	Mouse	PMID:21258407
Biological Process	GO:0001701	in utero embryonic development	Flcn	IMP	MGI:MGI:4348628	Mouse	PMID:21258407
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	Flcn	IMP	MGI:MGI:4348628	Mouse	PMID:21258407
Biological Process	GO:0032418	lysosome localization	FLCN	IDA		Human	PMID:27113757
Biological Process	GO:2001170	negative regulation of ATP biosynthetic process	Flcn	IMP		Mouse	MGI:MGI:5463828\|PMID:23150719
Biological Process	GO:1903444	negative regulation of brown fat cell differentiation	Flcn	IMP		Mouse	MGI:MGI:6393150\|PMID:27913603
Biological Process	GO:0030308	negative regulation of cell growth	FLCN	IDA		Human	PMID:20573232
Biological Process	GO:0030336	negative regulation of cell migration	FLCN	IMP		Human	PMID:22965878
Biological Process	GO:0008285	negative regulation of cell population proliferation	Flcn	IGI	MGI:MGI:2683054,MGI:MGI:2444668	Mouse	PMID:25775561
Biological Process	GO:1901723	negative regulation of cell proliferation involved in kidney development	Flcn	IMP	MGI:MGI:3774416	Mouse	PMID:19850877
Biological Process	GO:1901723	negative regulation of cell proliferation involved in kidney development	Flcn	IMP	MGI:MGI:3774414	Mouse	PMID:18182616
Biological Process	GO:1901723	negative regulation of cell proliferation involved in kidney development	Flcn	IMP	MGI:MGI:3842151	Mouse	PMID:19843504
Biological Process	GO:1901723	negative regulation of cell proliferation involved in kidney development	Flcn	IMP	MGI:MGI:3829641	Mouse	PMID:18974783
Biological Process	GO:1901856	negative regulation of cellular respiration	Flcn	IMP		Mouse	MGI:MGI:5463828\|PMID:23150719
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Flcn	IMP		Mouse	MGI:MGI:5779568\|PMID:27151976
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Flcn	IMP		Mouse	MGI:MGI:5487525\|PMID:21209915
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Flcn	IMP	MGI:MGI:3774414	Mouse	PMID:18182616
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Flcn	IMP	MGI:MGI:3842151	Mouse	PMID:19843504
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Flcn	IMP	MGI:MGI:4348628	Mouse	PMID:21258407
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Flcn	IMP	MGI:MGI:3774414	Mouse	PMID:18182616
Biological Process	GO:0010629	negative regulation of gene expression	Flcn	IMP		Mouse	MGI:MGI:5463828\|PMID:23150719
Biological Process	GO:0045820	negative regulation of glycolytic process	FLCN	IDA		Human	PMID:34381247
Biological Process	GO:1901859	negative regulation of mitochondrial DNA metabolic process	Flcn	IMP		Mouse	MGI:MGI:5463828\|PMID:23150719
Biological Process	GO:0010823	negative regulation of mitochondrion organization	Flcn	IMP		Mouse	MGI:MGI:5463828\|PMID:23150719
Biological Process	GO:1901862	negative regulation of muscle tissue development	Flcn	IMP		Mouse	MGI:MGI:5463828\|PMID:23150719
Biological Process	GO:1901874	negative regulation of post-translational protein modification	Flcn	IMP		Mouse	MGI:MGI:5487525\|PMID:21209915
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Flcn	IMP	MGI:MGI:3774416	Mouse	PMID:19850877
Biological Process	GO:1900181	negative regulation of protein localization to nucleus	FLCN	IDA		Human	PMID:21209915
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	FLCN	IMP		Human	PMID:22965878
Biological Process	GO:0032007	negative regulation of TOR signaling	Flcn	IMP	MGI:MGI:3774414	Mouse	PMID:18182616
Biological Process	GO:0032007	negative regulation of TOR signaling	Flcn	IMP	MGI:MGI:3829641	Mouse	PMID:18974783
Biological Process	GO:0032007	negative regulation of TOR signaling	Flcn	IMP	MGI:MGI:4348628	Mouse	PMID:21258407
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	FLCN	IDA		Human	PMID:20573232
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	FLCN	IMP		Human	PMID:21209915
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Flcn	IMP		Mouse	MGI:MGI:5487525\|PMID:21209915
Biological Process	GO:0010508	positive regulation of autophagy	FLCN	IDA		Human	PMID:25126726
Biological Process	GO:0010508	positive regulation of autophagy	FLCN	IMP		Human	PMID:25126726
Biological Process	GO:0045785	positive regulation of cell adhesion	FLCN	IMP		Human	PMID:21209915
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	Flcn	IMP	MGI:MGI:4348628	Mouse	PMID:21258407
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Flcn	IMP		Mouse	MGI:MGI:5487525\|PMID:21209915
Biological Process	GO:0032008	positive regulation of TOR signaling	FLCN	IDA		Human	PMID:24081491
Biological Process	GO:0032008	positive regulation of TOR signaling	FLCN	IDA		Human	PMID:24095279
Biological Process	GO:0032008	positive regulation of TOR signaling	FLCN	IDA		Human	PMID:31672913
Biological Process	GO:0032008	positive regulation of TOR signaling	FLCN	IDA		Human	PMID:31704029
Biological Process	GO:0032008	positive regulation of TOR signaling	Flcn	IMP	MGI:MGI:3842151	Mouse	PMID:19234517
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FLCN	IDA		Human	PMID:20573232
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FLCN	IMP		Human	PMID:21209915
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	FLCN	IDA		Human	PMID:20573232
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	Flcn	IMP	MGI:MGI:4348628	Mouse	PMID:21258407
Biological Process	GO:0043491	protein kinase B signaling	Flcn	IMP	MGI:MGI:3774416	Mouse	PMID:19850877
Biological Process	GO:0032465	regulation of cytokinesis	FLCN	IMP		Human	PMID:22965878
Biological Process	GO:2000973	regulation of pro-B cell differentiation	Flcn	IMP	MGI:MGI:3774414	Mouse	PMID:22709692
Biological Process	GO:0001932	regulation of protein phosphorylation	FLCN	IDA		Human	PMID:18663353
Biological Process	GO:0046578	regulation of Ras protein signal transduction	FLCN	IDA		Human	PMID:24081491
Biological Process	GO:0046578	regulation of Ras protein signal transduction	FLCN	IDA		Human	PMID:24095279
Biological Process	GO:0046578	regulation of Ras protein signal transduction	FLCN	IDA		Human	PMID:31672913
Biological Process	GO:0046578	regulation of Ras protein signal transduction	FLCN	IDA		Human	PMID:31704029
Biological Process	GO:0032006	regulation of TOR signaling	Flcn	IMP	MGI:MGI:3842151	Mouse	PMID:19843504
Biological Process	GO:0031929	TOR signaling	FLCN	IMP		Human	PMID:17028174
Biological Process	GO:0031929	TOR signaling	Flcn	IMP	MGI:MGI:3842151	Mouse	PMID:19234517
Biological Process	GO:0031929	TOR signaling	Flcn	IMP	MGI:MGI:4348628	Mouse	PMID:21258407
Biological Process	GO:0031929	TOR signaling	Flcn	IMP	MGI:MGI:3774414	Mouse	PMID:18182616
Biological Process	GO:0031929	TOR signaling	Flcn	IMP	MGI:MGI:3829641	Mouse	PMID:18974783
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Flcn	IMP	MGI:MGI:4348628	Mouse	PMID:21258407

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.