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Flcn
Gene Detail
 Symbol
Name
ID
Flcn
folliculin
MGI:2442184
Synonyms B430214A04Rik, BHD
Feature Type protein coding gene
Genetic Map
Chromosome 11
37.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:59791408-59810016 bp, - strand
From VEGA annotation of GRCm38

  18609 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14583  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Flcn

Human
homologs
Human Homolog FLCN, folliculin
NCBI Gene ID 201163
neXtProt AC  NX_Q8NFG4
Human Synonyms  BHD, FLCL
Human Chr (Location)  17p11.2; chr17:17212209-17237190 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human FLCN
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(12) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for either of two different knock-out alleles exhibit prenatal lethality. Mice homozygous for a gene-trapped allele show prenatal lethality while a fraction of heterozygotes develop spontaneous oncocytic renal cysts and solid renal tumors.
 
Human Diseases Modeled Using Mouse Flcn (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Flcn interacts with 143 markers (Mir7-1, Mir15a, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process cell-cell junction assembly, hemopoiesis, ...
Component cell-cell contact zone, cytoplasm, ...
Function protein binding, protein complex binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (58)    Tissues (41)    Images (20)
Theiler Stages: 7, 9, 10, 11, 12, 13, 15, 17, 20, 26, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 25
In situ reporter (knock in) 2
Western blot 9
RT-PCR 21
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000008092 (Evidence)
Ensembl Gene ModelENSMUSG00000032633 (Evidence)
Entrez Gene216805 (Evidence)
DFCITC1572046, TC1649293, TC1673926
DoTSDT.101207350, DT.101339522, DT.101360832, DT.110533381, DT.110533438, DT.492574, DT.94218757, DT.99859685
NIA Mouse Gene IndexU032856
Consensus CDS ProjectCCDS24777.1
International Mouse Knockout Project StatusFlcn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008092 VEGA Gene Model | MGI Sequence Detail 18609 C57BL/6J ±  kb
transcript OTTMUST00000018400 VEGA | MGI Sequence Detail 3437 Not Applicable 
polypeptide OTTMUSP00000008459 VEGA | MGI Sequence Detail 579 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(7) UniProt(3)
Polymorphisms SNPs within 2kb(254 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021713 Folliculin
Protein Ontology PR:000007550 folliculin
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:201807 Petit CS, et al., Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases. J Cell Biol. 2013 Sep 30;202(7):1107-22
All references(44)
Disease annotation references (2)
Other
accession IDs
MGI:2144365

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory