Flcn Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Flcn
folliculin
MGI:2442184

32 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Flcn^{Gt(RRX115)Byg}/Flcn⁺ involves: 129P2/OlaHsd * C57BL/6	increased incidence of tumors by chemical induction	J:147582
	increased kidney tumor incidence	J:147582
	increased lymphoma incidence	J:147582
	kidney cyst	J:147582
Flcn^{Gt(RRX115)Byg}/Flcn^{Gt(RRX115)Byg} involves: 129P2/OlaHsd * C57BL/6	abnormal egg cylinder morphology	J:173708
	abnormal endoderm development	J:173708
	embryonic lethality between implantation and somite formation, complete penetrance	J:173708
	prenatal lethality, complete penetrance	J:147582
Flcn^tm1.1Btt/Flcn^tm1.1Btt involves: 129S4/SvJaeSor * C57BL/6	embryonic lethality, complete penetrance	J:143922
Flcn^tm1.1Lss/Flcn^tm1.1Lss involves: C57BL/6 * FVB/N * SJL	prenatal lethality, complete penetrance	J:130978
Flcn^tm1Baba/Flcn^tm1.1Lss Tg(CAG-cre/Esr1)1Lbe/0 involves: 129S1/Sv 129X1/SvJ	arrested B cell differentiation	J:189078
	decreased B cell number	J:189078
	kidney cyst	J:189078
	kidney failure	J:189078
Flcn^tm1Baba/Flcn^tm1.1Lss Tg(Cdh16-cre)91Igr/0 involves: C57BL/6 * FVB/N * ICR * SJL	abnormal kidney collecting duct morphology	J:130978
	abnormal kidney corticomedullary boundary morphology	J:130978
	abnormal kidney pyramid morphology	J:130978
	abnormal kidney vasculature morphology	J:130978
	abnormal renal tubule morphology	J:130978
	dilated kidney collecting duct	J:130978
	dilated renal tubule	J:130978
	distended abdomen	J:130978
	enlarged kidney	J:130978
	increased blood urea nitrogen level	J:130978
	increased kidney cell proliferation	J:130978
	increased kidney weight	J:130978
	kidney cyst	J:130978
	kidney failure	J:130978
	postnatal lethality, complete penetrance	J:130978
	premature death	J:130978
Flcn^tm1Btt/Flcn^tm1Btt Tg(Cdh16-cre)91Igr/0 involves: 129S4/SvJaeSor * C57BL/6 * ICR	abnormal renal tubule epithelium morphology	J:143922
	dilated kidney collecting duct	J:143922
	dilated proximal convoluted tubule	J:143922
	increased blood urea nitrogen level	J:143922
	increased kidney weight	J:143922
	increased renal carcinoma incidence	J:143922
	kidney failure	J:143922
	kidney hemorrhage	J:143922
	polycystic kidney	J:143922
	postnatal lethality, complete penetrance	J:143922
	renal glomerulus atrophy	J:143922

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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