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Transgene Detail
Symbol: Tg(CAG-cre/Esr1*)1Lbe
Name: transgene insertion 1, Corrinne Lobe
MGI ID: MGI:2677720
Synonyms: actin-creER, beta-actin-CreER, CAGG-CreER, CX-CreERx, pCX-CreERTM, Tg(ACTB-cre/Esr1)1Lbe, Tg(CAG-cre/Esr1)1Lbe
Transgene: Tg(CAG-cre/Esr1*)1Lbe  Location: unknown  
Alliance: Tg(CAG-cre/Esr1*)1Lbe page
Germline Transmission:  Earliest citation of germline transmission: J:81562
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
Tg(CAG-cre/Esr1*)1Lbe expression driven by 1 gene
Mutation detailsThis transgenic construct was generated by ligating sequence encoding a fusion protein of cre recombinase and a mutant mouse estrogen receptor ligand binding domain to a CMV early enhancer and chicken beta-actin promoter. In the absence of ligand binding, the fusion protein remains in the cytoplasm. Binding of 4-hydroxytamoxifen enables the fusion protein to move to nucleus where it may act upon DNA. This transgenic line was generated by electroporating the contstruct into ES cells. Expression of the fusion protein was in a widespread mosaic pattern. Two lines were generated, BD8 with two copies of the transgene and CA6 with one copy. (J:81562)
 Tissue activity of this recombinase allele
Driver: CAG (chicken)
Summary of all recombinase alleles driven by CAG.

View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Tumor Data
List all tumor models in MMHCdb carrying Tg(CAG-cre/Esr1*)1Lbe
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:81562 Guo C, et al., A Cre recombinase transgene with mosaic, widespread tamoxifen-inducible action. Genesis. 2002 Jan;32(1):8-18
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory