| GO term: | TOR signaling cascade |
| Synonym: | target of rapamycin signaling pathway |
| Synonym: | target of rapamycin signalling pathway |
| Synonym: | TOR signaling pathway |
| Synonym: | TOR signalling pathway |
| GO id: | GO:0031929 |
| Definition: | A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. |
| Comments | Note that this term should not be confused with 'torso signaling pathway ; GO:0008293', although torso is abbreviated 'tor'. |
| Number of paths to term: | 10 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade [GO:0031929] (45 genes, 55 annotations)negative regulation of TOR signaling cascadepositive regulation of TOR signaling cascaderegulation of TOR signaling cascade +TRAF-mediated signal transductionbiological_processcellular processregulation of cellular processsignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade [GO:0031929] (45 genes, 55 annotations)negative regulation of TOR signaling cascadepositive regulation of TOR signaling cascaderegulation of TOR signaling cascade +TRAF-mediated signal transductionbiological_processcellular processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade [GO:0031929] (45 genes, 55 annotations)negative regulation of TOR signaling cascadepositive regulation of TOR signaling cascaderegulation of TOR signaling cascade +TRAF-mediated signal transductionbiological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade [GO:0031929] (45 genes, 55 annotations)negative regulation of TOR signaling cascadepositive regulation of TOR signaling cascaderegulation of TOR signaling cascade +TRAF-mediated signal transductionbiological_processregulation of biological processregulation of cellular processsignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade [GO:0031929] (45 genes, 55 annotations)negative regulation of TOR signaling cascadepositive regulation of TOR signaling cascaderegulation of TOR signaling cascade +TRAF-mediated signal transductionbiological_processresponse to stimuluscellular response to stimulussignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade [GO:0031929] (45 genes, 55 annotations)negative regulation of TOR signaling cascadepositive regulation of TOR signaling cascaderegulation of TOR signaling cascade +TRAF-mediated signal transductionbiological_processsignalingsingle organism signalingsignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade [GO:0031929] (45 genes, 55 annotations)negative regulation of TOR signaling cascadepositive regulation of TOR signaling cascaderegulation of TOR signaling cascade +TRAF-mediated signal transductionbiological_processsingle-organism processsingle organism signalingsignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade [GO:0031929] (45 genes, 55 annotations)negative regulation of TOR signaling cascadepositive regulation of TOR signaling cascaderegulation of TOR signaling cascade +TRAF-mediated signal transductionbiological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade [GO:0031929] (45 genes, 55 annotations)negative regulation of TOR signaling cascadepositive regulation of TOR signaling cascaderegulation of TOR signaling cascade +TRAF-mediated signal transductionbiological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade [GO:0031929] (45 genes, 55 annotations)negative regulation of TOR signaling cascadepositive regulation of TOR signaling cascaderegulation of TOR signaling cascade +TRAF-mediated signal transductionMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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