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Gene Ontology Browser
Term Detail
GO term:intrinsic apoptotic signaling pathway
Synonym: induction of apoptosis by intracellular signals
Synonym: intrinsic apoptosis
Synonym: intrinsic apoptotic pathway
Synonym: intrinsic apoptotic signalling pathway
Synonym: mitochondrial-mediated apoptotic pathway
GO id:GO:0097193
Definition:A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
CommentsThe signals that start intrinsic apoptosis may come from extracellular sources (e.g. oxidative stress, UV exposure), but the reception of the signal and thus the signaling pathway start inside the cell (as a result of DNA damage, redox imbalance, etc.). Examples are ZPR9 (ZNF622) and ASK1 (MAP3K5) (UniProt symbols Q969S3 and Q99683) in PMID:21771788. A diagram of the intrinsic apoptotic pathway including examples of molecular players can be found in Figure 2 in PMID:21760595.
Number of paths to term: 21

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aapoptotic signaling pathway
                                                        part-ofapoptosome assembly
                                                        is-aextrinsic apoptotic signaling pathway +
                                                        is-agranzyme-mediated apoptotic signaling pathway
                                                        is-ahormone-mediated apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                                is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                                is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                                is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                regulatesregulation of intrinsic apoptotic signaling pathway +
                                                        part-ofmitochondrial outer membrane permeabilization +
                                                        negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of apoptotic signaling pathway +
                                                        part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                        regulatesregulation of apoptotic signaling pathway +
                                                        part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aintracellular signal transduction
                                                        is-acytoplasmic pattern recognition receptor signaling pathway +
                                                        is-aendosomal signal transduction
                                                        is-ahippo signaling +
                                                        is-aI-kappaB kinase/NF-kappaB signaling +
                                                        is-ainositol lipid-mediated signaling +
                                                        is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                                is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                                is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                                is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                regulatesregulation of intrinsic apoptotic signaling pathway +
                                                        is-aJAK-STAT cascade +
                                                        is-aMAPK cascade +
                                                        is-aMAPK import into nucleus involved in innate immune response
                                                        negatively-regulatesnegative regulation of intracellular signal transduction +
                                                        is-aNIK/NF-kappaB signaling +
                                                        is-aphosphorelay signal transduction system +
                                                        is-aPKR signal transduction
                                                        positively-regulatespositive regulation of intracellular signal transduction +
                                                        is-aprotein kinase A signaling +
                                                        is-aprotein kinase B signaling +
                                                        is-aprotein kinase C signaling +
                                                        is-aprotein kinase D signaling +
                                                        regulatesregulation of intracellular signal transduction +
                                                        is-asecond-messenger-mediated signaling +
                                                        is-asignal transduction by p53 class mediator +
                                                        is-asignal transduction downstream of smoothened +
                                                        is-asignal transduction in response to DNA damage +
                                                        is-asignal transduction involved in cell cycle checkpoint +
                                                        is-asmall GTPase mediated signal transduction +
                                                        is-astress-activated protein kinase signaling cascade +
                                                        is-aTOR signaling +
                                                        is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                        is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                        is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aphosphorelay signal transduction system +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                is-aprotein kinase D signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                        is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                        is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aphosphorelay signal transduction system +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                is-aprotein kinase D signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aapoptotic signaling pathway
                                                        part-ofapoptosome assembly
                                                        is-aextrinsic apoptotic signaling pathway +
                                                        is-agranzyme-mediated apoptotic signaling pathway
                                                        is-ahormone-mediated apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                                is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                                is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                                is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                regulatesregulation of intrinsic apoptotic signaling pathway +
                                                        part-ofmitochondrial outer membrane permeabilization +
                                                        negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of apoptotic signaling pathway +
                                                        part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                        regulatesregulation of apoptotic signaling pathway +
                                                        part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-acytoplasmic pattern recognition receptor signaling pathway +
                                                        is-aendosomal signal transduction
                                                        is-ahippo signaling +
                                                        is-aI-kappaB kinase/NF-kappaB signaling +
                                                        is-ainositol lipid-mediated signaling +
                                                        is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                                is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                                is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                                is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                regulatesregulation of intrinsic apoptotic signaling pathway +
                                                        is-aJAK-STAT cascade +
                                                        is-aMAPK cascade +
                                                        is-aMAPK import into nucleus involved in innate immune response
                                                        negatively-regulatesnegative regulation of intracellular signal transduction +
                                                        is-aNIK/NF-kappaB signaling +
                                                        is-aphosphorelay signal transduction system +
                                                        is-aPKR signal transduction
                                                        positively-regulatespositive regulation of intracellular signal transduction +
                                                        is-aprotein kinase A signaling +
                                                        is-aprotein kinase B signaling +
                                                        is-aprotein kinase C signaling +
                                                        is-aprotein kinase D signaling +
                                                        regulatesregulation of intracellular signal transduction +
                                                        is-asecond-messenger-mediated signaling +
                                                        is-asignal transduction by p53 class mediator +
                                                        is-asignal transduction downstream of smoothened +
                                                        is-asignal transduction in response to DNA damage +
                                                        is-asignal transduction involved in cell cycle checkpoint +
                                                        is-asmall GTPase mediated signal transduction +
                                                        is-astress-activated protein kinase signaling cascade +
                                                        is-aTOR signaling +
                                                        is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic signaling pathway
                                                                part-ofapoptosome assembly
                                                                is-aextrinsic apoptotic signaling pathway +
                                                                is-agranzyme-mediated apoptotic signaling pathway
                                                                is-ahormone-mediated apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                                        is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                        regulatesregulation of intrinsic apoptotic signaling pathway +
                                                                part-ofmitochondrial outer membrane permeabilization +
                                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                                regulatesregulation of apoptotic signaling pathway +
                                                                part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                        is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                        is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aphosphorelay signal transduction system +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                is-aprotein kinase D signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                        is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                        is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aphosphorelay signal transduction system +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                is-aprotein kinase D signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                        is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                        is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aphosphorelay signal transduction system +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                is-aprotein kinase D signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-adeath
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic signaling pathway
                                                                part-ofapoptosome assembly
                                                                is-aextrinsic apoptotic signaling pathway +
                                                                is-agranzyme-mediated apoptotic signaling pathway
                                                                is-ahormone-mediated apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                                        is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                        regulatesregulation of intrinsic apoptotic signaling pathway +
                                                                part-ofmitochondrial outer membrane permeabilization +
                                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                                regulatesregulation of apoptotic signaling pathway +
                                                                part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                        is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                        is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aphosphorelay signal transduction system +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                is-aprotein kinase D signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aapoptotic signaling pathway
                                                        part-ofapoptosome assembly
                                                        is-aextrinsic apoptotic signaling pathway +
                                                        is-agranzyme-mediated apoptotic signaling pathway
                                                        is-ahormone-mediated apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                                is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                                is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                                is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                regulatesregulation of intrinsic apoptotic signaling pathway +
                                                        part-ofmitochondrial outer membrane permeabilization +
                                                        negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of apoptotic signaling pathway +
                                                        part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                        regulatesregulation of apoptotic signaling pathway +
                                                        part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-acytoplasmic pattern recognition receptor signaling pathway +
                                                        is-aendosomal signal transduction
                                                        is-ahippo signaling +
                                                        is-aI-kappaB kinase/NF-kappaB signaling +
                                                        is-ainositol lipid-mediated signaling +
                                                        is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                                is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                                is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                                is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                regulatesregulation of intrinsic apoptotic signaling pathway +
                                                        is-aJAK-STAT cascade +
                                                        is-aMAPK cascade +
                                                        is-aMAPK import into nucleus involved in innate immune response
                                                        negatively-regulatesnegative regulation of intracellular signal transduction +
                                                        is-aNIK/NF-kappaB signaling +
                                                        is-aphosphorelay signal transduction system +
                                                        is-aPKR signal transduction
                                                        positively-regulatespositive regulation of intracellular signal transduction +
                                                        is-aprotein kinase A signaling +
                                                        is-aprotein kinase B signaling +
                                                        is-aprotein kinase C signaling +
                                                        is-aprotein kinase D signaling +
                                                        regulatesregulation of intracellular signal transduction +
                                                        is-asecond-messenger-mediated signaling +
                                                        is-asignal transduction by p53 class mediator +
                                                        is-asignal transduction downstream of smoothened +
                                                        is-asignal transduction in response to DNA damage +
                                                        is-asignal transduction involved in cell cycle checkpoint +
                                                        is-asmall GTPase mediated signal transduction +
                                                        is-astress-activated protein kinase signaling cascade +
                                                        is-aTOR signaling +
                                                        is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic signaling pathway
                                                                part-ofapoptosome assembly
                                                                is-aextrinsic apoptotic signaling pathway +
                                                                is-agranzyme-mediated apoptotic signaling pathway
                                                                is-ahormone-mediated apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway [GO:0097193] (248 genes, 352 annotations)
                                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia +
                                                                        is-aintrinsic apoptotic signaling pathway in response to nitrosative stress
                                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                        regulatesregulation of intrinsic apoptotic signaling pathway +
                                                                part-ofmitochondrial outer membrane permeabilization +
                                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                                regulatesregulation of apoptotic signaling pathway +
                                                                part-ofrelease of cytochrome c from mitochondria +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory