| GO term: | intrinsic apoptotic signaling pathway |
| Synonym: | induction of apoptosis by intracellular signals |
| Synonym: | intrinsic apoptosis |
| Synonym: | intrinsic apoptotic pathway |
| Synonym: | intrinsic apoptotic signalling pathway |
| Synonym: | mitochondrial-mediated apoptotic pathway |
| GO id: | GO:0097193 |
| Definition: | A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). |
| Comments | The signals that start intrinsic apoptosis may come from extracellular sources (e.g. oxidative stress, UV exposure), but the reception of the signal and thus the signaling pathway start inside the cell (as a result of DNA damage, redox imbalance, etc.). |
| Number of paths to term: | 40 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade +TRAF-mediated signal transductionbiological_processcellular processregulation of cellular processregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processcellular processregulation of cellular processsignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processcellular processregulation of cellular processsignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade +TRAF-mediated signal transductionbiological_processcellular processsingle-organism cellular processcell communicationsignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processcellular processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade +TRAF-mediated signal transductionbiological_processcellular processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processcellular processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processexecution phase of apoptosisregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processcellular processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processcellular processsingle-organism cellular processcell deathprogrammed cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processcellular processsingle-organism cellular processcell deathregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade +TRAF-mediated signal transductionbiological_processcellular processsingle-organism cellular processexecution phase of apoptosisregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processregulation of biological processregulation of cellular processregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processregulation of biological processregulation of cellular processsignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processregulation of biological processregulation of cellular processsignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade +TRAF-mediated signal transductionbiological_processresponse to stimuluscellular response to stimulussignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processresponse to stimuluscellular response to stimulussignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade +TRAF-mediated signal transductionbiological_processsignalingsingle organism signalingsignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsignalingsingle organism signalingsignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade +TRAF-mediated signal transductionbiological_processsingle-organism processdeathcell deathprogrammed cell deathapoptotic processapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processdeathcell deathprogrammed cell deathapoptotic processexecution phase of apoptosisregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processdeathcell deathprogrammed cell deathapoptotic processregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processdeathcell deathprogrammed cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processdeathcell deathregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processsingle organism signalingsignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processsingle organism signalingsignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade +TRAF-mediated signal transductionbiological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade +TRAF-mediated signal transductionbiological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processexecution phase of apoptosisregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processsingle-organism cellular processcell deathregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductioncytoplasmic pattern recognition receptor signaling pathway +endosomal signal transductionhippo signaling cascade +inositol lipid-mediated signaling +intracellular protein kinase cascade +intrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +MAPK import into nucleus involved in innate immune responseNIK/NF-kappaB cascade +PKR signal transductionsecond-messenger-mediated signaling +signal transduction by p53 class mediator +signal transduction downstream of smoothened +signal transduction in response to DNA damage +signal transduction involved in cell cycle checkpoint +small GTPase mediated signal transduction +TOR signaling cascade +TRAF-mediated signal transductionbiological_processsingle-organism processsingle-organism cellular processexecution phase of apoptosisregulation of execution phase of apoptosisapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway [GO:0097193] (114 genes, 148 annotations)intrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressintrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
||
|
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support. |
last database update 05/08/2013 MGI 5.13 |
|
|
|
||
Analysis Tools