Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse F2r

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes F2R
- Mouse genes F2r
- Rat genes F2r
- Zfish genes f2r
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set F2r

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	F2r	IMP		Mouse	MGI:MGI:5285163\|PMID:20215560
Molecular Function	GO:0001965	G-protein alpha-subunit binding	F2r	IDA		Mouse	MGI:MGI:5285163\|PMID:20215560
Molecular Function	GO:0031681	G-protein beta-subunit binding	F2r	IDA		Mouse	MGI:MGI:5285163\|PMID:20215560
Molecular Function	GO:0005515	protein binding	F2R	IPI	UniProtKB:Q9UNN8	Human	PMID:17299037
Molecular Function	GO:0005515	protein binding	F2R	IPI	UniProtKB:Q03135	Human	PMID:17848177
Molecular Function	GO:0005515	protein binding	F2R	IPI	UniProtKB:D4ADZ2	Human	PMID:20164183
Molecular Function	GO:0005515	protein binding	F2R	IPI	UniProtKB:Q8BR07	Human	PMID:20164183
Molecular Function	GO:0005515	protein binding	F2R	IPI	UniProtKB:Q03135	Human	PMID:20826780
Molecular Function	GO:0005515	protein binding	F2R	IPI	UniProtKB:Q9UNN8	Human	PMID:20826780
Molecular Function	GO:0005515	protein binding	F2R	IPI	UniProtKB:Q8WUM4	Human	PMID:22547407
Molecular Function	GO:0005515	protein binding	F2R	IPI	UniProtKB:P35232	Human	PMID:24732013
Molecular Function	GO:0005102	signaling receptor binding	F2R	IPI	UniProtKB:P25116	Human	PMID:1672265
Molecular Function	GO:0015057	thrombin-activated receptor activity	F2R	IDA		Human	PMID:10692450
Molecular Function	GO:0015057	thrombin-activated receptor activity	F2R	IDA		Human	PMID:1672265
Molecular Function	GO:0015057	thrombin-activated receptor activity	f2r	IDA		Zfish	PMID:21181945
Cellular Component	GO:0005901	caveola	F2R	IDA		Human	PMID:17848177
Cellular Component	GO:0009986	cell surface	F2R	IDA		Human	PMID:24732013
Cellular Component	GO:0005769	early endosome	F2R	IDA		Human	PMID:22547407
Cellular Component	GO:0005769	early endosome	F2R	IDA		Human	PMID:24732013
Cellular Component	GO:0005770	late endosome	F2R	IDA		Human	PMID:24732013
Cellular Component	GO:0031594	neuromuscular junction	F2r	IDA		Rat	PMID:12815704\|RGD:1582330
Cellular Component	GO:0005886	plasma membrane	F2R	IDA		Human	PMID:22547407
Cellular Component	GO:0005886	plasma membrane	F2R	IDA		Human	PMID:9038223
Cellular Component	GO:0005886	plasma membrane	F2r	IDA		Rat	PMID:15145074\|RGD:1582290
Cellular Component	GO:0031094	platelet dense tubular network	F2R	IDA		Human	PMID:9038223
Cellular Component	GO:0045211	postsynaptic membrane	F2r	IDA		Rat	PMID:12815704\|RGD:1582330
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	F2R	IDA		Human	PMID:10692450
Biological Process	GO:0045217	cell-cell junction maintenance	F2R	IMP		Human	PMID:23202369
Biological Process	GO:0072359	circulatory system development	f2r	IMP	ZFIN:ZDB-MRPHLNO-120816-5	Zfish	PMID:22860064
Biological Process	GO:0072359	circulatory system development	f2r	IMP	ZFIN:ZDB-MRPHLNO-120604-3	Zfish	PMID:22860064
Biological Process	GO:0002248	connective tissue replacement involved in inflammatory response wound healing	F2R	IDA		Human	PMID:9639571
Biological Process	GO:0036145	dendritic cell homeostasis	F2r	IMP	MGI:MGI:3038377	Mouse	PMID:18305483
Biological Process	GO:0098508	endothelial to hematopoietic transition	f2r	IMP	ZFIN:ZDB-MRPHLNO-120604-4	Zfish	PMID:22521721
Biological Process	GO:0007529	establishment of synaptic specificity at neuromuscular junction	F2r	IDA		Rat	PMID:12815704\|RGD:1582330
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	F2r	IDA		Rat	PMID:12372796\|RGD:728482
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	F2r	IMP	MGI:MGI:3038377	Mouse	PMID:18305483
Biological Process	GO:0006954	inflammatory response	F2r	IMP	MGI:MGI:3038377	Mouse	PMID:18305483
Biological Process	GO:0008285	negative regulation of cell population proliferation	F2R	IDA		Human	PMID:10692450
Biological Process	GO:0003105	negative regulation of glomerular filtration	F2r	IDA		Rat	PMID:12644441\|RGD:1582293
Biological Process	GO:1902037	negative regulation of hematopoietic stem cell differentiation	f2r	IMP	ZFIN:ZDB-MRPHLNO-120604-4	Zfish	PMID:22521721
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	F2r	IMP		Rat	PMID:11919511\|RGD:1582353
Biological Process	GO:1900134	negative regulation of renin secretion into blood stream	F2r	IDA		Mouse	MGI:MGI:5315674\|PMID:21859963
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	F2R	IDA		Human	PMID:20164183
Biological Process	GO:0030168	platelet activation	F2R	IDA		Human	PMID:9038223
Biological Process	GO:0030194	positive regulation of blood coagulation	F2R	IDA		Human	PMID:9038223
Biological Process	GO:0030194	positive regulation of blood coagulation	F2r	IMP		Mouse	PMID:18305483
Biological Process	GO:0030194	positive regulation of blood coagulation	F2r	IMP	MGI:MGI:3038377	Mouse	PMID:18305483
Biological Process	GO:0051928	positive regulation of calcium ion transport	F2r	IMP		Rat	PMID:15145074\|RGD:1582290
Biological Process	GO:0030335	positive regulation of cell migration	F2R	IMP		Human	PMID:9701242
Biological Process	GO:0030335	positive regulation of cell migration	F2r	IDA		Mouse	MGI:MGI:5285163\|PMID:20215560
Biological Process	GO:0008284	positive regulation of cell population proliferation	F2r	IDA		Rat	PMID:12372796\|RGD:728482
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	F2R	IDA		Human	PMID:9639571
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	F2R	IDA		Human	PMID:10692450
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	F2r	IDA		Mouse	MGI:MGI:5285163\|PMID:20215560
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	F2r	IMP		Rat	PMID:15145074\|RGD:1582290
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	F2R	IDA		Human	PMID:17848177
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	F2r	IDA		Mouse	MGI:MGI:5285163\|PMID:20215560
Biological Process	GO:0043547	positive regulation of GTPase activity	F2R	IMP		Human	PMID:23202369
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	F2R	IEP		Human	PMID:12761501
Biological Process	GO:0032755	positive regulation of interleukin-6 production	F2R	IDA		Human	PMID:11447194
Biological Process	GO:0032757	positive regulation of interleukin-8 production	F2R	IDA		Human	PMID:17404307
Biological Process	GO:0043410	positive regulation of MAPK cascade	F2R	IDA		Human	PMID:17848177
Biological Process	GO:0043410	positive regulation of MAPK cascade	F2r	IMP		Rat	PMID:12372796\|RGD:728482
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	F2r	IDA		Mouse	MGI:MGI:5285163\|PMID:20215560
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	F2r	IGI	MGI:MGI:88380	Mouse	PMID:18398001
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	F2R	IDA		Human	PMID:1672265
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	F2r	IDA		Mouse	MGI:MGI:5285163\|PMID:20215560
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	F2r	IDA		Rat	PMID:14699501\|RGD:1582292
Biological Process	GO:0045907	positive regulation of vasoconstriction	F2r	IDA		Mouse	MGI:MGI:5315674\|PMID:21859963
Biological Process	GO:0045907	positive regulation of vasoconstriction	F2r	IDA		Rat	PMID:12644441\|RGD:1582293
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	F2r	IMP		Rat	PMID:12644441\|RGD:1582293
Biological Process	GO:0030193	regulation of blood coagulation	F2R	IDA		Human	PMID:17848177
Biological Process	GO:0032651	regulation of interleukin-1 beta production	F2r	IMP	MGI:MGI:3038377	Mouse	PMID:18305483
Biological Process	GO:0051930	regulation of sensory perception of pain	F2r	IDA		Rat	PMID:12126749\|RGD:1582348
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	F2r	IMP		Rat	PMID:15145074\|RGD:1582290
Biological Process	GO:0032496	response to lipopolysaccharide	F2r	IMP	MGI:MGI:3038377	Mouse	PMID:18305483
Biological Process	GO:0009611	response to wounding	F2R	IDA		Human	PMID:9639571
Biological Process	GO:0070493	thrombin-activated receptor signaling pathway	F2r	IGI	MGI:MGI:88380	Mouse	PMID:18398001
Biological Process	GO:0070493	thrombin-activated receptor signaling pathway	f2r	IDA		Zfish	PMID:21181945\|ZFIN:ZDB-PUB-110103-12
Biological Process	GO:0099553	trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	F2r	IMP		Mouse	MGI:MGI:5816443\|PMID:21414931

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.