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Gene Ontology Browser
Term Detail
GO term:platelet activation
Synonym: blood coagulation, platelet activation
GO id:GO:0030168
Definition:A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
Number of paths to term: 8

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological quality
                                is-aregulation of body fluid levels
                                        is-ahemostasis
                                                is-ablood coagulation
                                                        part-ofblood coagulation, fibrin clot formation +
                                                        negatively-regulatesnegative regulation of blood coagulation +
                                                        part-ofplatelet activation [GO:0030168] (80 genes, 99 annotations)
                                                                negatively-regulatesnegative regulation of platelet activation
                                                                part-ofplatelet aggregation +
                                                                positively-regulatespositive regulation of platelet activation
                                                                regulatesregulation of platelet activation +
                                                        positively-regulatespositive regulation of blood coagulation +
                                                        regulatesregulation of blood coagulation +
                                                        part-ofthrombocyte activation


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell activation
                                        is-aastrocyte activation +
                                        is-acell activation involved in immune response +
                                        is-achondrocyte activation
                                        is-aegg activation +
                                        is-aendothelial cell activation +
                                        is-afibroblast activation +
                                        is-afollicular dendritic cell activation +
                                        is-akeratinocyte activation
                                        is-aleukocyte activation +
                                        negatively-regulatesnegative regulation of cell activation +
                                        is-aneuroblast activation
                                        is-aplatelet activation [GO:0030168] (80 genes, 99 annotations)
                                                negatively-regulatesnegative regulation of platelet activation
                                                part-ofplatelet aggregation +
                                                positively-regulatespositive regulation of platelet activation
                                                regulatesregulation of platelet activation +
                                        positively-regulatespositive regulation of cell activation +
                                        regulatesregulation of cell activation +
                                        is-askeletal muscle satellite cell activation +
                                        is-athrombocyte activation


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-acoagulation
                                        is-ablood coagulation
                                                part-ofblood coagulation, fibrin clot formation +
                                                negatively-regulatesnegative regulation of blood coagulation +
                                                part-ofplatelet activation [GO:0030168] (80 genes, 99 annotations)
                                                        negatively-regulatesnegative regulation of platelet activation
                                                        part-ofplatelet aggregation +
                                                        positively-regulatespositive regulation of platelet activation
                                                        regulatesregulation of platelet activation +
                                                positively-regulatespositive regulation of blood coagulation +
                                                regulatesregulation of blood coagulation +
                                                part-ofthrombocyte activation


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-aregulation of body fluid levels
                                        is-ahemostasis
                                                is-ablood coagulation
                                                        part-ofblood coagulation, fibrin clot formation +
                                                        negatively-regulatesnegative regulation of blood coagulation +
                                                        part-ofplatelet activation [GO:0030168] (80 genes, 99 annotations)
                                                                negatively-regulatesnegative regulation of platelet activation
                                                                part-ofplatelet aggregation +
                                                                positively-regulatespositive regulation of platelet activation
                                                                regulatesregulation of platelet activation +
                                                        positively-regulatespositive regulation of blood coagulation +
                                                        regulatesregulation of blood coagulation +
                                                        part-ofthrombocyte activation


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-aresponse to wounding
                                        is-awound healing
                                                part-ofblood coagulation
                                                        part-ofblood coagulation, fibrin clot formation +
                                                        negatively-regulatesnegative regulation of blood coagulation +
                                                        part-ofplatelet activation [GO:0030168] (80 genes, 99 annotations)
                                                                negatively-regulatesnegative regulation of platelet activation
                                                                part-ofplatelet aggregation +
                                                                positively-regulatespositive regulation of platelet activation
                                                                regulatesregulation of platelet activation +
                                                        positively-regulatespositive regulation of blood coagulation +
                                                        regulatesregulation of blood coagulation +
                                                        part-ofthrombocyte activation


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-acoagulation
                                        is-ablood coagulation
                                                part-ofblood coagulation, fibrin clot formation +
                                                negatively-regulatesnegative regulation of blood coagulation +
                                                part-ofplatelet activation [GO:0030168] (80 genes, 99 annotations)
                                                        negatively-regulatesnegative regulation of platelet activation
                                                        part-ofplatelet aggregation +
                                                        positively-regulatespositive regulation of platelet activation
                                                        regulatesregulation of platelet activation +
                                                positively-regulatespositive regulation of blood coagulation +
                                                regulatesregulation of blood coagulation +
                                                part-ofthrombocyte activation


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-aregulation of body fluid levels
                                        is-ahemostasis
                                                is-ablood coagulation
                                                        part-ofblood coagulation, fibrin clot formation +
                                                        negatively-regulatesnegative regulation of blood coagulation +
                                                        part-ofplatelet activation [GO:0030168] (80 genes, 99 annotations)
                                                                negatively-regulatesnegative regulation of platelet activation
                                                                part-ofplatelet aggregation +
                                                                positively-regulatespositive regulation of platelet activation
                                                                regulatesregulation of platelet activation +
                                                        positively-regulatespositive regulation of blood coagulation +
                                                        regulatesregulation of blood coagulation +
                                                        part-ofthrombocyte activation


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell activation
                                        is-aastrocyte activation +
                                        is-acell activation involved in immune response +
                                        is-achondrocyte activation
                                        is-aegg activation +
                                        is-aendothelial cell activation +
                                        is-afibroblast activation +
                                        is-afollicular dendritic cell activation +
                                        is-akeratinocyte activation
                                        is-aleukocyte activation +
                                        negatively-regulatesnegative regulation of cell activation +
                                        is-aneuroblast activation
                                        is-aplatelet activation [GO:0030168] (80 genes, 99 annotations)
                                                negatively-regulatesnegative regulation of platelet activation
                                                part-ofplatelet aggregation +
                                                positively-regulatespositive regulation of platelet activation
                                                regulatesregulation of platelet activation +
                                        positively-regulatespositive regulation of cell activation +
                                        regulatesregulation of cell activation +
                                        is-askeletal muscle satellite cell activation +
                                        is-athrombocyte activation


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory