| GO term: | elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway |
| Synonym: | elevation of calcium ion concentration in cytoplasm during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) |
| Synonym: | elevation of calcium ion concentration in cytosol during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) |
| Synonym: | elevation of cytoplasmic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) |
| Synonym: | elevation of cytoplasmic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating) |
| Synonym: | elevation of cytosolic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating) |
| Synonym: | elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger |
| GO id: | GO:0051482 |
| Definition: | Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G-protein coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol. |
| Number of paths to term: | 26 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayphospholipase C-activating G-protein coupled receptor signaling pathwayelevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-activating adrenergic receptor signaling pathwayphospholipase C-activating angiotensin-mediated signaling pathway +phospholipase C-activating dopamine receptor signaling pathway +phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayphospholipase C-activating G-protein coupled glutamate receptor signaling pathwayphospholipase C-activating rhodopsin mediated signaling pathwayphospholipase C-activating serotonin receptor signaling pathwayphospholipase C-activating tachykinin receptor signaling pathwaypositive regulation of phospholipase C-activating G-protein coupled receptor signaling pathwayregulation of phospholipase C-activating G-protein coupled receptor signaling pathway +biological_processbiological regulationregulation of biological qualityhomeostatic processcellular homeostasiscellular chemical homeostasiscellular ion homeostasiscellular cation homeostasiscellular divalent inorganic cation homeostasiscellular calcium ion homeostasiscytosolic calcium ion homeostasiselevation of cytosolic calcium ion concentrationcalcium ion transport into cytosol +elevation of cytosolic calcium ion concentration involved in egg activation +elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)biological_processbiological regulationregulation of biological qualityhomeostatic processcellular homeostasiscellular chemical homeostasiscellular ion homeostasiscellular cation homeostasiscellular metal ion homeostasiscellular calcium ion homeostasiscytosolic calcium ion homeostasiselevation of cytosolic calcium ion concentrationcalcium ion transport into cytosol +elevation of cytosolic calcium ion concentration involved in egg activation +elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)biological_processbiological regulationregulation of biological qualityhomeostatic processchemical homeostasiscellular chemical homeostasiscellular ion homeostasiscellular cation homeostasiscellular divalent inorganic cation homeostasiscellular calcium ion homeostasiscytosolic calcium ion homeostasiselevation of cytosolic calcium ion concentrationcalcium ion transport into cytosol +elevation of cytosolic calcium ion concentration involved in egg activation +elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)biological_processbiological regulationregulation of biological qualityhomeostatic processchemical homeostasiscellular chemical homeostasiscellular ion homeostasiscellular cation homeostasiscellular metal ion homeostasiscellular calcium ion homeostasiscytosolic calcium ion homeostasiselevation of cytosolic calcium ion concentrationcalcium ion transport into cytosol +elevation of cytosolic calcium ion concentration involved in egg activation +elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)biological_processbiological regulationregulation of biological qualityhomeostatic processchemical homeostasision homeostasiscation homeostasiscellular cation homeostasiscellular divalent inorganic cation homeostasiscellular calcium ion homeostasiscytosolic calcium ion homeostasiselevation of cytosolic calcium ion concentrationcalcium ion transport into cytosol +elevation of cytosolic calcium ion concentration involved in egg activation +elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)biological_processbiological regulationregulation of biological qualityhomeostatic processchemical homeostasision homeostasiscation homeostasiscellular cation homeostasiscellular metal ion homeostasiscellular calcium ion homeostasiscytosolic calcium ion homeostasiselevation of cytosolic calcium ion concentrationcalcium ion transport into cytosol +elevation of cytosolic calcium ion concentration involved in egg activation +elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)biological_processbiological regulationregulation of biological qualityhomeostatic processchemical homeostasision homeostasiscation homeostasisdivalent inorganic cation homeostasiscalcium ion homeostasiscellular calcium ion homeostasiscytosolic calcium ion homeostasiselevation of cytosolic calcium ion concentrationcalcium ion transport into cytosol +elevation of cytosolic calcium ion concentration involved in egg activation +elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)biological_processbiological regulationregulation of biological qualityhomeostatic processchemical homeostasision homeostasiscation homeostasisdivalent inorganic cation homeostasiscellular divalent inorganic cation homeostasiscellular calcium ion homeostasiscytosolic calcium ion homeostasiselevation of cytosolic calcium ion concentrationcalcium ion transport into cytosol +elevation of cytosolic calcium ion concentration involved in egg activation +elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)biological_processbiological regulationregulation of biological qualityhomeostatic processchemical homeostasision homeostasiscation homeostasismetal ion homeostasiscalcium ion homeostasiscellular calcium ion homeostasiscytosolic calcium ion homeostasiselevation of cytosolic calcium ion concentrationcalcium ion transport into cytosol +elevation of cytosolic calcium ion concentration involved in egg activation +elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)biological_processbiological regulationregulation of biological qualityhomeostatic processchemical homeostasision homeostasiscation homeostasismetal ion homeostasiscellular metal ion homeostasiscellular calcium ion homeostasiscytosolic calcium ion homeostasiselevation of cytosolic calcium ion concentrationcalcium ion transport into cytosol +elevation of cytosolic calcium ion concentration involved in egg activation +elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)biological_processbiological regulationregulation of biological qualityhomeostatic processchemical homeostasision homeostasiscellular ion homeostasiscellular cation homeostasiscellular divalent inorganic cation homeostasiscellular calcium ion homeostasiscytosolic calcium ion homeostasiselevation of cytosolic calcium ion concentrationcalcium ion transport into cytosol +elevation of cytosolic calcium ion concentration involved in egg activation +elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)biological_processbiological regulationregulation of biological qualityhomeostatic processchemical homeostasision homeostasiscellular ion homeostasiscellular cation homeostasiscellular metal ion homeostasiscellular calcium ion homeostasiscytosolic calcium ion homeostasiselevation of cytosolic calcium ion concentrationcalcium ion transport into cytosol +elevation of cytosolic calcium ion concentration involved in egg activation +elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)biological_processcellular processregulation of cellular processsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayphospholipase C-activating G-protein coupled receptor signaling pathwayelevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-activating adrenergic receptor signaling pathwayphospholipase C-activating angiotensin-mediated signaling pathway +phospholipase C-activating dopamine receptor signaling pathway +phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayphospholipase C-activating G-protein coupled glutamate receptor signaling pathwayphospholipase C-activating rhodopsin mediated signaling pathwayphospholipase C-activating serotonin receptor signaling pathwayphospholipase C-activating tachykinin receptor signaling pathwaypositive regulation of phospholipase C-activating G-protein coupled receptor signaling pathwayregulation of phospholipase C-activating G-protein coupled receptor signaling pathway +biological_processcellular processsingle-organism cellular processcell communicationsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayphospholipase C-activating G-protein coupled receptor signaling pathwayelevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-activating adrenergic receptor signaling pathwayphospholipase C-activating angiotensin-mediated signaling pathway +phospholipase C-activating dopamine receptor signaling pathway +phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayphospholipase C-activating G-protein coupled glutamate receptor signaling pathwayphospholipase C-activating rhodopsin mediated signaling pathwayphospholipase C-activating serotonin receptor signaling pathwayphospholipase C-activating tachykinin receptor signaling pathwaypositive regulation of phospholipase C-activating G-protein coupled receptor signaling pathwayregulation of phospholipase C-activating G-protein coupled receptor signaling pathway +biological_processcellular processsingle-organism cellular processcellular homeostasiscellular chemical homeostasiscellular ion homeostasiscellular cation homeostasiscellular divalent inorganic cation homeostasiscellular calcium ion homeostasiscytosolic calcium ion homeostasiselevation of cytosolic calcium ion concentrationcalcium ion transport into cytosol +elevation of cytosolic calcium ion concentration involved in egg activation +elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)biological_processcellular processsingle-organism cellular processcellular homeostasiscellular chemical homeostasiscellular ion homeostasiscellular cation homeostasiscellular metal ion homeostasiscellular calcium ion homeostasiscytosolic calcium ion homeostasiselevation of cytosolic calcium ion concentrationcalcium ion transport into cytosol +elevation of cytosolic calcium ion concentration involved in egg activation +elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayphospholipase C-activating G-protein coupled receptor signaling pathwayelevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-activating adrenergic receptor signaling pathwayphospholipase C-activating angiotensin-mediated signaling pathway +phospholipase C-activating dopamine receptor signaling pathway +phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayphospholipase C-activating G-protein coupled glutamate receptor signaling pathwayphospholipase C-activating rhodopsin mediated signaling pathwayphospholipase C-activating serotonin receptor signaling pathwayphospholipase C-activating tachykinin receptor signaling pathwaypositive regulation of phospholipase C-activating G-protein coupled receptor signaling pathwayregulation of phospholipase C-activating G-protein coupled receptor signaling pathway +biological_processregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayphospholipase C-activating G-protein coupled receptor signaling pathwayelevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-activating adrenergic receptor signaling pathwayphospholipase C-activating angiotensin-mediated signaling pathway +phospholipase C-activating dopamine receptor signaling pathway +phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayphospholipase C-activating G-protein coupled glutamate receptor signaling pathwayphospholipase C-activating rhodopsin mediated signaling pathwayphospholipase C-activating serotonin receptor signaling pathwayphospholipase C-activating tachykinin receptor signaling pathwaypositive regulation of phospholipase C-activating G-protein coupled receptor signaling pathwayregulation of phospholipase C-activating G-protein coupled receptor signaling pathway +biological_processresponse to stimuluscellular response to stimulussignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayphospholipase C-activating G-protein coupled receptor signaling pathwayelevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-activating adrenergic receptor signaling pathwayphospholipase C-activating angiotensin-mediated signaling pathway +phospholipase C-activating dopamine receptor signaling pathway +phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayphospholipase C-activating G-protein coupled glutamate receptor signaling pathwayphospholipase C-activating rhodopsin mediated signaling pathwayphospholipase C-activating serotonin receptor signaling pathwayphospholipase C-activating tachykinin receptor signaling pathwaypositive regulation of phospholipase C-activating G-protein coupled receptor signaling pathwayregulation of phospholipase C-activating G-protein coupled receptor signaling pathway +biological_processsignalingsingle organism signalingsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayphospholipase C-activating G-protein coupled receptor signaling pathwayelevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-activating adrenergic receptor signaling pathwayphospholipase C-activating angiotensin-mediated signaling pathway +phospholipase C-activating dopamine receptor signaling pathway +phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayphospholipase C-activating G-protein coupled glutamate receptor signaling pathwayphospholipase C-activating rhodopsin mediated signaling pathwayphospholipase C-activating serotonin receptor signaling pathwayphospholipase C-activating tachykinin receptor signaling pathwaypositive regulation of phospholipase C-activating G-protein coupled receptor signaling pathwayregulation of phospholipase C-activating G-protein coupled receptor signaling pathway +biological_processsingle-organism processsingle organism signalingsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayphospholipase C-activating G-protein coupled receptor signaling pathwayelevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-activating adrenergic receptor signaling pathwayphospholipase C-activating angiotensin-mediated signaling pathway +phospholipase C-activating dopamine receptor signaling pathway +phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayphospholipase C-activating G-protein coupled glutamate receptor signaling pathwayphospholipase C-activating rhodopsin mediated signaling pathwayphospholipase C-activating serotonin receptor signaling pathwayphospholipase C-activating tachykinin receptor signaling pathwaypositive regulation of phospholipase C-activating G-protein coupled receptor signaling pathwayregulation of phospholipase C-activating G-protein coupled receptor signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayphospholipase C-activating G-protein coupled receptor signaling pathwayelevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-activating adrenergic receptor signaling pathwayphospholipase C-activating angiotensin-mediated signaling pathway +phospholipase C-activating dopamine receptor signaling pathway +phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayphospholipase C-activating G-protein coupled glutamate receptor signaling pathwayphospholipase C-activating rhodopsin mediated signaling pathwayphospholipase C-activating serotonin receptor signaling pathwayphospholipase C-activating tachykinin receptor signaling pathwaypositive regulation of phospholipase C-activating G-protein coupled receptor signaling pathwayregulation of phospholipase C-activating G-protein coupled receptor signaling pathway +biological_processsingle-organism processsingle-organism cellular processcellular homeostasiscellular chemical homeostasiscellular ion homeostasiscellular cation homeostasiscellular divalent inorganic cation homeostasiscellular calcium ion homeostasiscytosolic calcium ion homeostasiselevation of cytosolic calcium ion concentrationcalcium ion transport into cytosol +elevation of cytosolic calcium ion concentration involved in egg activation +elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)biological_processsingle-organism processsingle-organism cellular processcellular homeostasiscellular chemical homeostasiscellular ion homeostasiscellular cation homeostasiscellular metal ion homeostasiscellular calcium ion homeostasiscytosolic calcium ion homeostasiselevation of cytosolic calcium ion concentrationcalcium ion transport into cytosol +elevation of cytosolic calcium ion concentration involved in egg activation +elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayphospholipase C-activating G-protein coupled receptor signaling pathwayelevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482] (14 genes, 14 annotations)negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-activating adrenergic receptor signaling pathwayphospholipase C-activating angiotensin-mediated signaling pathway +phospholipase C-activating dopamine receptor signaling pathway +phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayphospholipase C-activating G-protein coupled glutamate receptor signaling pathwayphospholipase C-activating rhodopsin mediated signaling pathwayphospholipase C-activating serotonin receptor signaling pathwayphospholipase C-activating tachykinin receptor signaling pathwaypositive regulation of phospholipase C-activating G-protein coupled receptor signaling pathwayregulation of phospholipase C-activating G-protein coupled receptor signaling pathway +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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