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F2r
Gene Detail
 Symbol
Name
ID
F2r
coagulation factor II (thrombin) receptor
MGI:101802
Synonyms Cf2r, Par1, thrombin receptor, ThrR
Feature Type protein coding gene
Genetic Map
Chromosome 13
50.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr13:95601789-95618433 bp, - strand
From NCBI annotation of GRCm38

  16645 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1510  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: proteinase-activated receptor
Gene Tree: F2r

Human
homologs
Human Homolog F2R, coagulation factor II (thrombin) receptor
NCBI Gene ID 2149
neXtProt AC  NX_P25116
Human Synonyms  CF2R, HTR, PAR1, PAR-1, TR
Human Chr (Location)  5q13; chr5:76716043-76735770 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(5) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted mutations of this locus result in increased midgestational lethality, with up to ~50% of mutants surviving to adulthood. Gene deficiency does not affect thrombin signaling in mouse platelets but markedly attenuates thrombin signaling in mouse microvascular endothelial cells.
 
Interactions
F2r interacts with 223 markers (Mir10b, Mir16-1, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (72 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of MAPKK activity, ...
Component caveola, cell, ...
Function G-protein alpha-subunit binding, G-protein beta-subunit binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (157)    Tissues (109)    Images (41)
Theiler Stages: 11, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 137
In situ reporter (knock in) 6
RT-PCR 14
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(4) cDNA(10) Primer pair(4) Other(3)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000048376 (Evidence)
Entrez Gene14062 (Evidence)
DFCITC1572371
DoTSDT.110971791, DT.489079
NIA Mouse Gene IndexU035056
Consensus CDS ProjectCCDS26701.1
International Mouse Knockout Project StatusF2r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14062 NCBI Gene Model | MGI Sequence Detail 16645 C57BL/6J ±  kb
transcript NM_010169 RefSeq | MGI Sequence Detail 3296 C57BL/6 
polypeptide P30558 UniProt | EBI | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR003912 Protease-activated receptor
InterPro IPR000935 Thrombin receptor
Protein Ontology PR:000001661 proteinase-activated receptor 1
Graphical View of Protein Domain Structure
References (Earliest) J:16414 Soifer SJ, et al., Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development. Am J Pathol. 1994 Jan;144(1):60-9
(Latest) J:203434 Aronovich A, et al., A novel role for factor VIII and thrombin/PAR1 in regulating hematopoiesis and its interplay with the bone structure. Blood. 2013 Oct 10;122(15):2562-71
All references(115)
Other
accession IDs
MGD-MRK-18613, MGI:2145260

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory