Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Eif2ak3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes EIF2AK3
- Mouse genes Eif2ak3
- Rat genes Eif2ak3
- Zfish genes eif2ak3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eif2ak3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	EIF2AK3	IPI	UniProtKB:Q8N5Y8	Human	PMID:23103912
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	EIF2AK3	IDA		Human	PMID:10026192
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	EIF2AK3	IDA		Human	PMID:10677345
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	EIF2AK3	IDA		Human	PMID:11907036
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	EIF2AK3	IMP		Human	PMID:12086964
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	EIF2AK3	IMP		Human	PMID:25329545
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	Eif2ak3	IMP		Mouse	MGI:MGI:3722921\|PMID:14729979
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	Eif2ak3	IDA		Mouse	MGI:MGI:1333015\|PMID:9930704
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	Eif2ak3	IDA		Rat	PMID:9819435\|RGD:70729
Molecular Function	GO:0051879	Hsp90 protein binding	Eif2ak3	IDA		Rat	PMID:12446770\|RGD:10047277
Molecular Function	GO:0042802	identical protein binding	EIF2AK3	IPI	UniProtKB:Q9NZJ5	Human	PMID:11907036
Molecular Function	GO:0042802	identical protein binding	Eif2ak3	IPI	UniProtKB:Q9Z2B5	Mouse	MGI:MGI:6092864\|PMID:16973740
Molecular Function	GO:0005515	protein binding	EIF2AK3	IPI	UniProtKB:P11021	Human	PMID:11907036
Molecular Function	GO:0005515	protein binding	EIF2AK3	IPI	UniProtKB:P14625	Human	PMID:11907036
Molecular Function	GO:0005515	protein binding	EIF2AK3	IPI	UniProtKB:Q9Y4P3	Human	PMID:25393282
Molecular Function	GO:0005515	protein binding	EIF2AK3	IPI	UniProtKB:P57088	Human	PMID:26268696
Molecular Function	GO:0005515	protein binding	EIF2AK3	IPI	UniProtKB:P11021	Human	PMID:27238082
Molecular Function	GO:0005515	protein binding	Eif2ak3	IPI	UniProtKB:P27958:PRO_0000037569	Mouse	MGI:MGI:5516172\|PMID:23667408
Molecular Function	GO:0005515	protein binding	Eif2ak3	IPI	UniProtKB:Q80U63	Mouse	MGI:MGI:5506952\|PMID:23921556
Molecular Function	GO:0005515	protein binding	Eif2ak3	IPI	UniProtKB:P27958:PRO_0000037570	Mouse	MGI:MGI:5516172\|PMID:23667408
Molecular Function	GO:0005515	protein binding	Eif2ak3	IPI	UniProtKB:P27958:PRO_0000037570	Mouse	MGI:MGI:5514336\|PMID:12610133
Molecular Function	GO:0005515	protein binding	Eif2ak3	IPI	UniProtKB:P05198	Mouse	MGI:MGI:3847871\|PMID:16288713
Molecular Function	GO:0005515	protein binding	Eif2ak3	IPI	UniProtKB:P11021\|UniProtKB:Q9QXT0	Mouse	MGI:MGI:6355684\|PMID:28869608
Molecular Function	GO:0005515	protein binding	Eif2ak3	IPI	PR:Q60795	Mouse	PMID:14517290
Molecular Function	GO:0004672	protein kinase activity	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:15542627
Molecular Function	GO:0004672	protein kinase activity	Eif2ak3	IDA		Mouse	PMID:14517290
Molecular Function	GO:0019903	protein phosphatase binding	EIF2AK3	IPI	UniProtKB:P18031	Human	PMID:22169477
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Eif2ak3	IDA		Mouse	PMID:9930704
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Eif2ak3	IDA		Rat	PMID:11781318\|RGD:632569
Cellular Component	GO:0005737	cytoplasm	Eif2ak3	IDA		Mouse	PMID:11747369
Cellular Component	GO:0005783	endoplasmic reticulum	Eif2ak3	IDA		Mouse	PMID:11430819
Cellular Component	GO:0005783	endoplasmic reticulum	Eif2ak3	IDA		Mouse	PMID:14517290
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Eif2ak3	IDA		Mouse	PMID:9930704
Cellular Component	GO:0044322	endoplasmic reticulum quality control compartment	Eif2ak3	IDA		Mouse	MGI:MGI:6467680\|PMID:17707796
Cellular Component	GO:0016020	membrane	EIF2AK3	HDA		Human	PMID:19946888
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Eif2ak3	IDA		Rat	PMID:15936177\|RGD:1581062
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:10882126
Biological Process	GO:0001525	angiogenesis	EIF2AK3	IMP		Human	PMID:22915762
Biological Process	GO:0030282	bone mineralization	Eif2ak3	IMP	MGI:MGI:2183829	Mouse	PMID:11997520
Biological Process	GO:0019722	calcium-mediated signaling	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:16352659
Biological Process	GO:0034198	cellular response to amino acid starvation	EIF2AK3	IMP		Human	PMID:25329545
Biological Process	GO:0070417	cellular response to cold	EIF2AK3	IMP		Human	PMID:25329545
Biological Process	GO:0042149	cellular response to glucose starvation	EIF2AK3	IMP		Human	PMID:22915762
Biological Process	GO:0042149	cellular response to glucose starvation	Eif2ak3	IMP		Mouse	MGI:MGI:5607215\|PMID:22915762
Biological Process	GO:0002063	chondrocyte development	Eif2ak3	IMP	MGI:MGI:2183829	Mouse	PMID:12865332
Biological Process	GO:0036492	eiF2alpha phosphorylation in response to endoplasmic reticulum stress	EIF2AK3	IMP		Human	PMID:25329545
Biological Process	GO:0036492	eiF2alpha phosphorylation in response to endoplasmic reticulum stress	Eif2ak3	IMP		Mouse	MGI:MGI:6467680\|PMID:17707796
Biological Process	GO:0031018	endocrine pancreas development	EIF2AK3	IMP		Human	PMID:12086964
Biological Process	GO:0007029	endoplasmic reticulum organization	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:11430819
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	EIF2AK3	IDA		Human	PMID:10677345
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	EIF2AK3	IDA		Human	PMID:11907036
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	EIF2AK3	IDA		Human	PMID:22169477
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Eif2ak3	IDA		Mouse	PMID:9930704
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:15911877
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Eif2ak3	IDA		Mouse	PMID:14517290
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:10882126
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:15542627
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:16176978
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:11430819
Biological Process	GO:0006983	ER overload response	EIF2AK3	IDA		Human	PMID:10677345
Biological Process	GO:0006983	ER overload response	EIF2AK3	IDA		Human	PMID:11907036
Biological Process	GO:0045444	fat cell differentiation	Eif2ak3	IDA		Mouse	PMID:18852460
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Eif2ak3	IMP	MGI:MGI:2183829	Mouse	PMID:12865332
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:11430819
Biological Process	GO:0007595	lactation	Eif2ak3	IMP	MGI:MGI:3774276	Mouse	PMID:18852460
Biological Process	GO:0043066	negative regulation of apoptotic process	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:15542627
Biological Process	GO:0010629	negative regulation of gene expression	Eif2ak3	IMP		Mouse	PMID:23152784
Biological Process	GO:0031642	negative regulation of myelination	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:15911877
Biological Process	GO:0017148	negative regulation of translation	Eif2ak3	IMP		Mouse	MGI:MGI:5514336\|PMID:12610133
Biological Process	GO:0017148	negative regulation of translation	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:16176978
Biological Process	GO:0017148	negative regulation of translation	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:10882126
Biological Process	GO:0017148	negative regulation of translation	Eif2ak3	IGI	MGI:MGI:1353427	Mouse	PMID:16176978
Biological Process	GO:0017148	negative regulation of translation	Eif2ak3	IDA		Mouse	PMID:9930704
Biological Process	GO:1902010	negative regulation of translation in response to endoplasmic reticulum stress	Eif2ak3	IDA		Mouse	MGI:MGI:1333015\|PMID:9930704
Biological Process	GO:0032055	negative regulation of translation in response to stress	Eif2ak3	IDA		Rat	PMID:9819435\|RGD:70729
Biological Process	GO:0001503	ossification	EIF2AK3	IMP		Human	PMID:12086964
Biological Process	GO:0031016	pancreas development	Eif2ak3	IMP	MGI:MGI:2183829	Mouse	PMID:11997520
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Eif2ak3	IDA		Mouse	MGI:MGI:1333015\|PMID:9930704
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Eif2ak3	IDA		Mouse	MGI:MGI:5613478\|PMID:14676213
Biological Process	GO:0036499	PERK-mediated unfolded protein response	Eif2ak3	IMP		Mouse	MGI:MGI:6467680\|PMID:17707796
Biological Process	GO:0036499	PERK-mediated unfolded protein response	Eif2ak3	IMP		Mouse	MGI:MGI:3722921\|PMID:14729979
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Eif2ak3	IGI	MGI:MGI:1913418	Mouse	PMID:22240901
Biological Process	GO:0010628	positive regulation of gene expression	EIF2AK3	IMP		Human	PMID:22915762
Biological Process	GO:0010628	positive regulation of gene expression	Eif2ak3	IMP		Mouse	MGI:MGI:3722921\|PMID:14729979
Biological Process	GO:1903788	positive regulation of glutathione biosynthetic process	Eif2ak3	IMP		Mouse	MGI:MGI:5616326\|PMID:14978030
Biological Process	GO:0032092	positive regulation of protein binding	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:16352659
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	Eif2ak3	IMP		Mouse	MGI:MGI:2677605\|PMID:14517290
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	Eif2ak3	IMP		Mouse	MGI:MGI:5616326\|PMID:14978030
Biological Process	GO:0009967	positive regulation of signal transduction	Eif2ak3	IDA		Mouse	PMID:18852460
Biological Process	GO:0045943	positive regulation of transcription by RNA polymerase I	EIF2AK3	IMP		Human	PMID:22915762
Biological Process	GO:0045943	positive regulation of transcription by RNA polymerase I	Eif2ak3	IMP		Mouse	MGI:MGI:5607215\|PMID:22915762
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	Eif2ak3	IMP		Mouse	MGI:MGI:3722921\|PMID:14729979
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	EIF2AK3	IMP		Human	PMID:22915762
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	Eif2ak3	IMP		Mouse	MGI:MGI:5607215\|PMID:22915762
Biological Process	GO:0046777	protein autophosphorylation	EIF2AK3	IDA		Human	PMID:10026192
Biological Process	GO:0046777	protein autophosphorylation	EIF2AK3	IDA		Human	PMID:11907036
Biological Process	GO:0046777	protein autophosphorylation	EIF2AK3	IMP		Human	PMID:12086964
Biological Process	GO:0046777	protein autophosphorylation	Eif2ak3	IDA		Mouse	MGI:MGI:5514336\|PMID:12610133
Biological Process	GO:0046777	protein autophosphorylation	Eif2ak3	IDA		Mouse	PMID:9930704
Biological Process	GO:0046777	protein autophosphorylation	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:15542627
Biological Process	GO:0046777	protein autophosphorylation	Eif2ak3	IDA		Rat	PMID:9819435\|RGD:70729
Biological Process	GO:0006468	protein phosphorylation	Eif2ak3	IDA		Mouse	PMID:9930704
Biological Process	GO:0006468	protein phosphorylation	Eif2ak3	IDA		Mouse	PMID:12388085
Biological Process	GO:0006468	protein phosphorylation	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:10882126
Biological Process	GO:0006468	protein phosphorylation	Eif2ak3	IDA		Mouse	PMID:14517290
Biological Process	GO:0006468	protein phosphorylation	Eif2ak3	IMP	MGI:MGI:2183829	Mouse	PMID:11997520
Biological Process	GO:0006468	protein phosphorylation	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:15542627
Biological Process	GO:0006468	protein phosphorylation	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:16176978
Biological Process	GO:0006468	protein phosphorylation	Eif2ak3	IMP	MGI:MGI:2177666	Mouse	PMID:11430819
Biological Process	GO:0006468	protein phosphorylation	Eif2ak3	IDA		Rat	PMID:9819435\|RGD:70729
Biological Process	GO:0060734	regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	Eif2ak3	IMP		Mouse	MGI:MGI:3582244\|PMID:11106749
Biological Process	GO:1902235	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	EIF2AK3	IMP		Human	PMID:23000344
Biological Process	GO:0019217	regulation of fatty acid metabolic process	Eif2ak3	IMP	MGI:MGI:3774276	Mouse	PMID:18852460
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	Eif2ak3	IMP		Mouse	MGI:MGI:1858648\|PMID:10882126
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	Eif2ak3	IDA		Mouse	MGI:MGI:5613478\|PMID:14676213
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	Eif2ak3	IMP		Mouse	MGI:MGI:3582244\|PMID:11106749
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	Eif2ak3	IMP		Mouse	MGI:MGI:3722921\|PMID:14729979
Biological Process	GO:0034976	response to endoplasmic reticulum stress	EIF2AK3	IMP		Human	PMID:19061639
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Eif2ak3	IMP		Mouse	MGI:MGI:5616326\|PMID:14978030
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Eif2ak3	IDA		Mouse	MGI:MGI:3582244\|PMID:11106749
Biological Process	GO:0034976	response to endoplasmic reticulum stress	eif2ak3	IMP	ZFIN:ZDB-MRPHLNO-180802-2	Zfish	PMID:29472449
Biological Process	GO:0034976	response to endoplasmic reticulum stress	eif2ak3	IMP	ZFIN:ZDB-GENO-121120-1	Zfish	PMID:29472449
Biological Process	GO:0034976	response to endoplasmic reticulum stress	eif2ak3	IGI	ZFIN:ZDB-GENO-190219-3	Zfish	PMID:29472449
Biological Process	GO:0001666	response to hypoxia	eif2ak3	IDA		Zfish	PMID:25814654
Biological Process	GO:1990737	response to manganese-induced endoplasmic reticulum stress	Eif2ak3	IEP		Rat	PMID:23934647\|RGD:10047151
Biological Process	GO:0001501	skeletal system development	Eif2ak3	IMP	MGI:MGI:2183829	Mouse	PMID:11997520
Biological Process	GO:0032933	SREBP signaling pathway	Eif2ak3	IDA		Mouse	PMID:18852460
Biological Process	GO:0006412	translation	Eif2ak3	IDA		Mouse	PMID:12388085
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	Eif2ak3	IMP		Mouse	MGI:MGI:6467680\|PMID:17707796

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.