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Eif2ak3
Gene Detail
Symbol

Name
ID
Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
MGI:1341830
Synonyms
PERK
Feature Type
protein coding gene
Genetic Map
Chromosome 6
32.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:70844515-70905245 bp, + strand
From VEGA annotation of GRCm38

  60731 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3557  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EIF2AK3
Gene Tree: Eif2ak3

Human
homologs
EIF2AK3, eukaryotic translation initiation factor 2-alpha kinase 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9451
neXtProt AC: NX_Q9NZJ5

Human Synonyms: PEK, PERK, WRS

Human Chr (Location): 2p12; chr2:88556741-88627576 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human EIF2AK3

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(6) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice develop exocrine pancreatic insufficiency and progressive diabetes mellitus. They are growth retarded, hyperglycemic, exhibit increased cell death in the pancreas, have decreased numbers of pancreatic beta cells and about half die before weaning.
 
Human Diseases Modeled in Mice Using Eif2ak3 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Eif2ak3 interacts with 190 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (94 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, angiogenesis, ...
Component cell, cytoplasm, ...
Function ATP binding, enzyme binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (11)    Tissues (11)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 1
RT-PCR 4
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase eif2ak3    NEW 
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000031093 (Evidence)
Ensembl Gene Model ENSMUSG00000031668 (Evidence)
Entrez Gene 13666 (Evidence)
DFCI TC1592041, TC1578234, TC1614519, TC1611018, TC1621492
DoTS DT.91388692, DT.91333595, DT.55198265, DT.526528, DT.101172659, DT.97336329
NIA Mouse Gene Index U061049, U061050, U007008
EC 2.7.11.1
PDB 3QD2
Consensus CDS Project CCDS20223.1
International Mouse Phenotyping Consortium Status Eif2ak3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031093 VEGA Gene Model | MGI Sequence Detail 60731 C57BL/6J ±  kb
transcript OTTMUST00000077032 VEGA | MGI Sequence Detail 4513 Not Applicable 
polypeptide OTTMUSP00000040627 VEGA | MGI Sequence Detail 1114 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(509 from dbSNP Build 137)    SNPs within 2kb including multiple locations(515)
Protein-related
information
ResourceIDDescription
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR027295 Quinonprotein alcohol dehydrogenase-like domain
InterPro IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000006960 eukaryotic translation initiation factor 2-alpha kinase 3
References
(Earliest) J:51759 Harding HP, et al., Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase [published erratum appears in Nature 1999 Mar 4;398(6722):90] [see comments]. Nature. 1999 Jan 21;397(6716):271-4
(Latest) J:218404 Roobol A, et al., p58IPK is an inhibitor of the eIF2alpha kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity. Biochem J. 2015 Jan 15;465(2):213-25
All references(109)
Disease annotation references (2)
Other
accession IDs
MGI:2141404

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory