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Eif2ak3
Gene Detail
 Symbol
Name
ID
Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
MGI:1341830
Synonyms PERK
Feature Type protein coding gene
Genetic Map
Chromosome 6
32.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:70844515-70905245 bp, + strand
From VEGA annotation of GRCm38

  60731 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3557  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Eif2ak3

Human
homologs
Human Homolog EIF2AK3, eukaryotic translation initiation factor 2-alpha kinase 3
NCBI Gene ID 9451
neXtProt AC  NX_Q9NZJ5
Human Synonyms  PEK, PERK, WRS
Human Chr (Location)  2p12; chr2:88556741-88627576 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human EIF2AK3
Alleles
and
phenotypes
All alleles(13) : Gene trapped(6) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice develop exocrine pancreatic insufficiency and progressive diabetes mellitus. They are growth retarded, hyperglycemic, exhibit increased cell death in the pancreas, have decreased numbers of pancreatic beta cells and about half die before weaning.
 
Human Diseases Modeled Using Mouse Eif2ak3 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (73 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, bone mineralization, ...
Component cell, cytoplasm, ...
Function ATP binding, enzyme binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (11)    Tissues (11)    Images (7)
Theiler Stages: 19, 20, 22, 24, 26, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 1
RT-PCR 4
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000031093 (Evidence)
Ensembl Gene ModelENSMUSG00000031668 (Evidence)
Entrez Gene13666 (Evidence)
DFCITC1578234, TC1592041, TC1611018, TC1614519, TC1621492
DoTSDT.101172659, DT.526528, DT.55198265, DT.91333595, DT.91388692, DT.97336329
NIA Mouse Gene IndexU007008, U061049, U061050
EC2.7.11.1
PDB3QD2
Consensus CDS ProjectCCDS20223.1
International Mouse Knockout Project StatusEif2ak3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031093 VEGA Gene Model | MGI Sequence Detail 60731 C57BL/6J ±  kb
transcript OTTMUST00000077032 VEGA | MGI Sequence Detail 4513 Not Applicable 
polypeptide OTTMUSP00000040627 VEGA | MGI Sequence Detail 1114 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(509 from dbSNP Build 137)    SNPs within 2kb including multiple locations(515)
Protein-related
information
ResourceIDDescription
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR027295 Quinonprotein alcohol dehydrogenase-like domain
InterPro IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000006960 eukaryotic translation initiation factor 2-alpha kinase 3
References (Earliest) J:51759 Harding HP, et al., Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase [published erratum appears in Nature 1999 Mar 4;398(6722):90] [see comments]. Nature. 1999 Jan 21;397(6716):271-4
(Latest) J:207477 Hussien Y, et al., Genetic inactivation of PERK signaling in mouse oligodendrocytes: Normal developmental myelination with increased susceptibility to inflammatory demyelination. Glia. 2014 May;62(5):680-91
All references(101)
Other
accession IDs
MGI:2141404

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory