Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.1.0)

Enables several functions, including identical protein binding activity; misfolded protein binding activity; and protein kinase activity. Involved in several processes, including PERK-mediated unfolded protein response; positive regulation of glutathione biosynthetic process; and regulation of gene expression. Acts upstream of or within several processes, including insulin-like growth factor receptor signaling pathway; intracellular signal transduction; and regulation of intrinsic apoptotic signaling pathway. Located in endoplasmic reticulum membrane and endoplasmic reticulum quality control compartment. Is expressed in several structures, including cerebral cortex; eye; liver; pancreas tip epithelium; and tooth. Used to study Wolcott-Rallison syndrome. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3).

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Gene Ontology Evidence Code Abbreviations:

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