Eif2ak3 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
MGI:1341830

11 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Eif2ak3^tm1.2Drc/Eif2ak3^tm1.2Drc Pten^tm1Hwu/Pten^tm1Hwu Tg(CAG-MYC,-GFP)#Rugg/0 Tg(Pbsn-cre)4Prb/0 involves: 129S4/SvJae 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2	decreased prostate gland tumor incidence	J:261540
Eif2ak3^tm1Dron/Eif2ak3⁺ Tg(GFAP-tTA)110Pop/0 Tg(tetO-Ifng)184Pop/0 involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * Swiss Webster	abnormal myelination	J:99655
	abnormal oligodendrocyte apoptosis	J:99655
	abnormal oligodendrocyte morphology	J:99655
	abnormal spinal cord white matter morphology	J:99655
	increased spinal cord apoptosis	J:99655
	postnatal growth retardation	J:99655
	premature death	J:99655
	tonic seizures	J:99655
	tremors	J:99655
Eif2ak3^tm1Dron/Eif2ak3^tm1Dron Tg(GFAP-tTA)110Pop/0 Tg(tetO-Ifng)184Pop/0 involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * Swiss Webster	postnatal lethality, complete penetrance	J:99655

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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