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Gene Ontology Browser
Term Detail
GO term:endoplasmic reticulum unfolded protein response
Synonym: ER unfolded protein response
Synonym: erUPR
Synonym: SREBP-mediated signalling pathway
GO id:GO:0030968
Definition:The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
CommentsNote that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'.
Number of paths to term: 23

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aapoptotic signaling pathway +
                                                is-abile acid signaling pathway +
                                                is-acarbohydrate mediated signaling +
                                                is-acell surface receptor signaling pathway +
                                                is-achloroplast-nucleus signaling pathway
                                                is-adefense response signaling pathway, resistance gene-dependent
                                                is-adefense response signaling pathway, resistance gene-independent
                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                        is-aATF6-mediated unfolded protein response +
                                                        is-aIRE1-mediated unfolded protein response +
                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                        is-aPERK-mediated unfolded protein response +
                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                is-aER-nucleus signaling pathway +
                                                is-ahormone-mediated signaling pathway +
                                                is-ahydrogen peroxide mediated signaling pathway +
                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                is-aimmune response-regulating signaling pathway +
                                                is-aintracellular receptor signaling pathway +
                                                is-aintracellular signal transduction +
                                                is-alipoprotein particle mediated signaling +
                                                is-amitochondria-nucleus signaling pathway
                                                is-anecroptotic signaling pathway
                                                negatively-regulatesnegative regulation of signal transduction +
                                                is-aneuronal signal transduction +
                                                is-aosmosensory signaling pathway +
                                                is-aphototransduction +
                                                positively-regulatespositive regulation of signal transduction +
                                                is-ared or far-red light signaling pathway +
                                                is-aregulation of blood pressure by chemoreceptor signaling pathway
                                                is-aregulation of floral organ abscission by signal transduction +
                                                regulatesregulation of signal transduction +
                                                is-asalicylic acid mediated signaling pathway +
                                                is-asignal transduction by conformational transition
                                                is-asignal transduction by phosphorylation +
                                                is-asignal transduction in absence of ligand +
                                                is-asignal transduction involved in cellular response to ammonium ion
                                                is-asignal transduction involved in conjugation with cellular fusion +
                                                is-asignal transduction involved in cytokinesis after mitosis checkpoint
                                                is-asignal transduction involved in Dma1-dependent checkpoint
                                                is-asignal transduction involved in filamentous growth
                                                is-asignal transduction involved in morphogenesis checkpoint
                                                is-asignal transduction involved in regulation of aerobic respiration
                                                is-asignal transduction involved in regulation of gene expression +
                                                is-aSMAD protein signal transduction
                                                is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to topologically incorrect protein
                                                        is-acellular response to unfolded protein
                                                                part-ofendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                        is-aATF6-mediated unfolded protein response +
                                                                        is-aIRE1-mediated unfolded protein response +
                                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                                        is-aPERK-mediated unfolded protein response +
                                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-acellular response to topologically incorrect protein
                                                is-acellular response to unfolded protein
                                                        part-ofendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                is-aATF6-mediated unfolded protein response +
                                                                is-aIRE1-mediated unfolded protein response +
                                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                                is-aPERK-mediated unfolded protein response +
                                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                        is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-aresponse to endoplasmic reticulum stress
                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                        is-aATF6-mediated unfolded protein response +
                                                        is-aIRE1-mediated unfolded protein response +
                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                        is-aPERK-mediated unfolded protein response +
                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                is-aER overload response +
                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                negatively-regulatesnegative regulation of response to endoplasmic reticulum stress +
                                                is-anegative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
                                                is-apositive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
                                                regulatesregulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
                                                is-aregulation of translation in response to endoplasmic reticulum stress +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                is-aATF6-mediated unfolded protein response +
                                                is-aIRE1-mediated unfolded protein response +
                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                is-aPERK-mediated unfolded protein response +
                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in cellular response to ammonium ion
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in cytokinesis after mitosis checkpoint
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in morphogenesis checkpoint
                                        is-asignal transduction involved in regulation of aerobic respiration
                                        is-asignal transduction involved in regulation of gene expression +
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                is-aATF6-mediated unfolded protein response +
                                                is-aIRE1-mediated unfolded protein response +
                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                is-aPERK-mediated unfolded protein response +
                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in cellular response to ammonium ion
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in cytokinesis after mitosis checkpoint
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in morphogenesis checkpoint
                                        is-asignal transduction involved in regulation of aerobic respiration
                                        is-asignal transduction involved in regulation of gene expression +
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aapoptotic signaling pathway +
                                                is-abile acid signaling pathway +
                                                is-acarbohydrate mediated signaling +
                                                is-acell surface receptor signaling pathway +
                                                is-achloroplast-nucleus signaling pathway
                                                is-adefense response signaling pathway, resistance gene-dependent
                                                is-adefense response signaling pathway, resistance gene-independent
                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                        is-aATF6-mediated unfolded protein response +
                                                        is-aIRE1-mediated unfolded protein response +
                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                        is-aPERK-mediated unfolded protein response +
                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                is-aER-nucleus signaling pathway +
                                                is-ahormone-mediated signaling pathway +
                                                is-ahydrogen peroxide mediated signaling pathway +
                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                is-aimmune response-regulating signaling pathway +
                                                is-aintracellular receptor signaling pathway +
                                                is-aintracellular signal transduction +
                                                is-alipoprotein particle mediated signaling +
                                                is-amitochondria-nucleus signaling pathway
                                                is-anecroptotic signaling pathway
                                                negatively-regulatesnegative regulation of signal transduction +
                                                is-aneuronal signal transduction +
                                                is-aosmosensory signaling pathway +
                                                is-aphototransduction +
                                                positively-regulatespositive regulation of signal transduction +
                                                is-ared or far-red light signaling pathway +
                                                is-aregulation of blood pressure by chemoreceptor signaling pathway
                                                is-aregulation of floral organ abscission by signal transduction +
                                                regulatesregulation of signal transduction +
                                                is-asalicylic acid mediated signaling pathway +
                                                is-asignal transduction by conformational transition
                                                is-asignal transduction by phosphorylation +
                                                is-asignal transduction in absence of ligand +
                                                is-asignal transduction involved in cellular response to ammonium ion
                                                is-asignal transduction involved in conjugation with cellular fusion +
                                                is-asignal transduction involved in cytokinesis after mitosis checkpoint
                                                is-asignal transduction involved in Dma1-dependent checkpoint
                                                is-asignal transduction involved in filamentous growth
                                                is-asignal transduction involved in morphogenesis checkpoint
                                                is-asignal transduction involved in regulation of aerobic respiration
                                                is-asignal transduction involved in regulation of gene expression +
                                                is-aSMAD protein signal transduction
                                                is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                is-aATF6-mediated unfolded protein response +
                                                is-aIRE1-mediated unfolded protein response +
                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                is-aPERK-mediated unfolded protein response +
                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in cellular response to ammonium ion
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in cytokinesis after mitosis checkpoint
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in morphogenesis checkpoint
                                        is-asignal transduction involved in regulation of aerobic respiration
                                        is-asignal transduction involved in regulation of gene expression +
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to topologically incorrect protein
                                                        is-acellular response to unfolded protein
                                                                part-ofendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                        is-aATF6-mediated unfolded protein response +
                                                                        is-aIRE1-mediated unfolded protein response +
                                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                                        is-aPERK-mediated unfolded protein response +
                                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-acellular response to topologically incorrect protein
                                                is-acellular response to unfolded protein
                                                        part-ofendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                is-aATF6-mediated unfolded protein response +
                                                                is-aIRE1-mediated unfolded protein response +
                                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                                is-aPERK-mediated unfolded protein response +
                                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                        is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-aresponse to endoplasmic reticulum stress
                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                        is-aATF6-mediated unfolded protein response +
                                                        is-aIRE1-mediated unfolded protein response +
                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                        is-aPERK-mediated unfolded protein response +
                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                is-aER overload response +
                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                negatively-regulatesnegative regulation of response to endoplasmic reticulum stress +
                                                is-anegative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
                                                is-apositive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
                                                regulatesregulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
                                                is-aregulation of translation in response to endoplasmic reticulum stress +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                is-aATF6-mediated unfolded protein response +
                                                is-aIRE1-mediated unfolded protein response +
                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                is-aPERK-mediated unfolded protein response +
                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in cellular response to ammonium ion
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in cytokinesis after mitosis checkpoint
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in morphogenesis checkpoint
                                        is-asignal transduction involved in regulation of aerobic respiration
                                        is-asignal transduction involved in regulation of gene expression +
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to topologically incorrect protein
                                                        is-acellular response to unfolded protein
                                                                part-ofendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                        is-aATF6-mediated unfolded protein response +
                                                                        is-aIRE1-mediated unfolded protein response +
                                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                                        is-aPERK-mediated unfolded protein response +
                                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-aresponse to organic substance
                                        is-acellular response to organic substance
                                                is-acellular response to topologically incorrect protein
                                                        is-acellular response to unfolded protein
                                                                part-ofendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                        is-aATF6-mediated unfolded protein response +
                                                                        is-aIRE1-mediated unfolded protein response +
                                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                                        is-aPERK-mediated unfolded protein response +
                                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-aresponse to organic substance
                                        is-aresponse to topologically incorrect protein
                                                is-acellular response to topologically incorrect protein
                                                        is-acellular response to unfolded protein
                                                                part-ofendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                        is-aATF6-mediated unfolded protein response +
                                                                        is-aIRE1-mediated unfolded protein response +
                                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                                        is-aPERK-mediated unfolded protein response +
                                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-aresponse to organic substance
                                        is-aresponse to topologically incorrect protein
                                                is-aresponse to unfolded protein
                                                        is-acellular response to unfolded protein
                                                                part-ofendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                        is-aATF6-mediated unfolded protein response +
                                                                        is-aIRE1-mediated unfolded protein response +
                                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                                        is-aPERK-mediated unfolded protein response +
                                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-acellular response to stress
                                        is-acellular response to topologically incorrect protein
                                                is-acellular response to unfolded protein
                                                        part-ofendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                is-aATF6-mediated unfolded protein response +
                                                                is-aIRE1-mediated unfolded protein response +
                                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                                is-aPERK-mediated unfolded protein response +
                                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                        is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-acellular response to stress
                                        is-aresponse to endoplasmic reticulum stress
                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                        is-aATF6-mediated unfolded protein response +
                                                        is-aIRE1-mediated unfolded protein response +
                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                        is-aPERK-mediated unfolded protein response +
                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                is-aER overload response +
                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                negatively-regulatesnegative regulation of response to endoplasmic reticulum stress +
                                                is-anegative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
                                                is-apositive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
                                                regulatesregulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
                                                is-aregulation of translation in response to endoplasmic reticulum stress +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-aresponse to topologically incorrect protein
                                        is-acellular response to topologically incorrect protein
                                                is-acellular response to unfolded protein
                                                        part-ofendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                is-aATF6-mediated unfolded protein response +
                                                                is-aIRE1-mediated unfolded protein response +
                                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                                is-aPERK-mediated unfolded protein response +
                                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                        is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-aresponse to topologically incorrect protein
                                        is-aresponse to unfolded protein
                                                is-acellular response to unfolded protein
                                                        part-ofendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                is-aATF6-mediated unfolded protein response +
                                                                is-aIRE1-mediated unfolded protein response +
                                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                                is-aPERK-mediated unfolded protein response +
                                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                        is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                is-aATF6-mediated unfolded protein response +
                                                is-aIRE1-mediated unfolded protein response +
                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                is-aPERK-mediated unfolded protein response +
                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in cellular response to ammonium ion
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in cytokinesis after mitosis checkpoint
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in morphogenesis checkpoint
                                        is-asignal transduction involved in regulation of aerobic respiration
                                        is-asignal transduction involved in regulation of gene expression +
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                is-aATF6-mediated unfolded protein response +
                                                is-aIRE1-mediated unfolded protein response +
                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                is-aPERK-mediated unfolded protein response +
                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in cellular response to ammonium ion
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in cytokinesis after mitosis checkpoint
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in morphogenesis checkpoint
                                        is-asignal transduction involved in regulation of aerobic respiration
                                        is-asignal transduction involved in regulation of gene expression +
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aapoptotic signaling pathway +
                                                is-abile acid signaling pathway +
                                                is-acarbohydrate mediated signaling +
                                                is-acell surface receptor signaling pathway +
                                                is-achloroplast-nucleus signaling pathway
                                                is-adefense response signaling pathway, resistance gene-dependent
                                                is-adefense response signaling pathway, resistance gene-independent
                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (51 genes, 75 annotations)
                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                        is-aATF6-mediated unfolded protein response +
                                                        is-aIRE1-mediated unfolded protein response +
                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response +
                                                        is-aPERK-mediated unfolded protein response +
                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response +
                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                is-aER-nucleus signaling pathway +
                                                is-ahormone-mediated signaling pathway +
                                                is-ahydrogen peroxide mediated signaling pathway +
                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                is-aimmune response-regulating signaling pathway +
                                                is-aintracellular receptor signaling pathway +
                                                is-aintracellular signal transduction +
                                                is-alipoprotein particle mediated signaling +
                                                is-amitochondria-nucleus signaling pathway
                                                is-anecroptotic signaling pathway
                                                negatively-regulatesnegative regulation of signal transduction +
                                                is-aneuronal signal transduction +
                                                is-aosmosensory signaling pathway +
                                                is-aphototransduction +
                                                positively-regulatespositive regulation of signal transduction +
                                                is-ared or far-red light signaling pathway +
                                                is-aregulation of blood pressure by chemoreceptor signaling pathway
                                                is-aregulation of floral organ abscission by signal transduction +
                                                regulatesregulation of signal transduction +
                                                is-asalicylic acid mediated signaling pathway +
                                                is-asignal transduction by conformational transition
                                                is-asignal transduction by phosphorylation +
                                                is-asignal transduction in absence of ligand +
                                                is-asignal transduction involved in cellular response to ammonium ion
                                                is-asignal transduction involved in conjugation with cellular fusion +
                                                is-asignal transduction involved in cytokinesis after mitosis checkpoint
                                                is-asignal transduction involved in Dma1-dependent checkpoint
                                                is-asignal transduction involved in filamentous growth
                                                is-asignal transduction involved in morphogenesis checkpoint
                                                is-asignal transduction involved in regulation of aerobic respiration
                                                is-asignal transduction involved in regulation of gene expression +
                                                is-aSMAD protein signal transduction
                                                is-asphingolipid mediated signaling pathway +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory