| GO term: | endoplasmic reticulum unfolded protein response |
| Synonym: | ER unfolded protein response |
| Synonym: | erUPR |
| Synonym: | SREBP-mediated signalling pathway |
| GO id: | GO:0030968 |
| Definition: | The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. |
| Comments | Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'. |
| Number of paths to term: | 27 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionER-nucleus signaling pathwayendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responseER overload response +SREBP signaling pathway +biological_processcellular processregulation of cellular processsignal transductionER-nucleus signaling pathwayendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responseER overload response +SREBP signaling pathway +biological_processcellular processsingle-organism cellular processcell communicationsignal transductionER-nucleus signaling pathwayendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responseER overload response +SREBP signaling pathway +biological_processcellular processsingle-organism cellular processcellular response to stimuluscellular response to chemical stimuluscellular response to organic substancecellular response to topologically incorrect proteincellular response to unfolded proteinendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responsemitochondrial unfolded protein responsebiological_processcellular processsingle-organism cellular processcellular response to stimuluscellular response to stresscellular response to topologically incorrect proteincellular response to unfolded proteinendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responsemitochondrial unfolded protein responsebiological_processcellular processsingle-organism cellular processcellular response to stimuluscellular response to stressresponse to endoplasmic reticulum stressendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responseER overload response +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressnegative regulation of translation involved in response to endoplasmic reticulum stressregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stressbiological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionER-nucleus signaling pathwayendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responseER overload response +SREBP signaling pathway +biological_processregulation of biological processregulation of cellular processsignal transductionER-nucleus signaling pathwayendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responseER overload response +SREBP signaling pathway +biological_processresponse to stimuluscellular response to stimuluscellular response to chemical stimuluscellular response to organic substancecellular response to topologically incorrect proteincellular response to unfolded proteinendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responsemitochondrial unfolded protein responsebiological_processresponse to stimuluscellular response to stimuluscellular response to stresscellular response to topologically incorrect proteincellular response to unfolded proteinendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responsemitochondrial unfolded protein responsebiological_processresponse to stimuluscellular response to stimuluscellular response to stressresponse to endoplasmic reticulum stressendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responseER overload response +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressnegative regulation of translation involved in response to endoplasmic reticulum stressregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stressbiological_processresponse to stimuluscellular response to stimulussignal transductionER-nucleus signaling pathwayendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responseER overload response +SREBP signaling pathway +biological_processresponse to stimulusresponse to chemical stimuluscellular response to chemical stimuluscellular response to organic substancecellular response to topologically incorrect proteincellular response to unfolded proteinendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responsemitochondrial unfolded protein responsebiological_processresponse to stimulusresponse to chemical stimulusresponse to organic substancecellular response to organic substancecellular response to topologically incorrect proteincellular response to unfolded proteinendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responsemitochondrial unfolded protein responsebiological_processresponse to stimulusresponse to chemical stimulusresponse to organic substanceresponse to topologically incorrect proteincellular response to topologically incorrect proteincellular response to unfolded proteinendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responsemitochondrial unfolded protein responsebiological_processresponse to stimulusresponse to chemical stimulusresponse to organic substanceresponse to topologically incorrect proteinresponse to unfolded proteincellular response to unfolded proteinendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responsemitochondrial unfolded protein responsebiological_processresponse to stimulusresponse to stresscellular response to stresscellular response to topologically incorrect proteincellular response to unfolded proteinendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responsemitochondrial unfolded protein responsebiological_processresponse to stimulusresponse to stresscellular response to stressresponse to endoplasmic reticulum stressendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responseER overload response +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressnegative regulation of translation involved in response to endoplasmic reticulum stressregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stressbiological_processresponse to stimulusresponse to stressresponse to topologically incorrect proteincellular response to topologically incorrect proteincellular response to unfolded proteinendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responsemitochondrial unfolded protein responsebiological_processresponse to stimulusresponse to stressresponse to topologically incorrect proteinresponse to unfolded proteincellular response to unfolded proteinendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responsemitochondrial unfolded protein responsebiological_processsignalingsingle organism signalingsignal transductionER-nucleus signaling pathwayendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responseER overload response +SREBP signaling pathway +biological_processsingle-organism processsingle organism signalingsignal transductionER-nucleus signaling pathwayendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responseER overload response +SREBP signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionER-nucleus signaling pathwayendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responseER overload response +SREBP signaling pathway +biological_processsingle-organism processsingle-organism cellular processcellular response to stimuluscellular response to chemical stimuluscellular response to organic substancecellular response to topologically incorrect proteincellular response to unfolded proteinendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responsemitochondrial unfolded protein responsebiological_processsingle-organism processsingle-organism cellular processcellular response to stimuluscellular response to stresscellular response to topologically incorrect proteincellular response to unfolded proteinendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responsemitochondrial unfolded protein responsebiological_processsingle-organism processsingle-organism cellular processcellular response to stimuluscellular response to stressresponse to endoplasmic reticulum stressendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responseER overload response +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressnegative regulation of translation involved in response to endoplasmic reticulum stressregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stressbiological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionER-nucleus signaling pathwayendoplasmic reticulum unfolded protein response [GO:0030968] (31 genes, 39 annotations)activation of signaling protein activity involved in unfolded protein responsenegative regulation of endoplasmic reticulum unfolded protein responsepositive regulation of endoplasmic reticulum unfolded protein responsepositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseregulation of endoplasmic reticulum unfolded protein response +UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein responseER overload response +SREBP signaling pathway +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
||
|
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support. |
last database update 05/22/2013 MGI 5.13 |
|
|
|
||
Analysis Tools