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Gene Ontology Browser
Term Detail
GO term:endoplasmic reticulum unfolded protein response
Synonym: ER unfolded protein response
Synonym: erUPR
Synonym: SREBP-mediated signalling pathway
GO id:GO:0030968
Definition:The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
CommentsNote that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'.
Number of paths to term: 23

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aER-nucleus signaling pathway
                                                        is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                        is-aER overload response +
                                                        is-aSREBP signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to topologically incorrect protein
                                                        is-acellular response to unfolded protein
                                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                        part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                                is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-acellular response to topologically incorrect protein
                                                is-acellular response to unfolded protein
                                                        is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                        is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-aresponse to endoplasmic reticulum stress
                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                        part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                is-aER overload response +
                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                part-ofnegative regulation of translation involved in response to endoplasmic reticulum stress
                                                is-aregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aER-nucleus signaling pathway
                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                        part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                is-aER overload response +
                                                is-aSREBP signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aER-nucleus signaling pathway
                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                        part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                is-aER overload response +
                                                is-aSREBP signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aER-nucleus signaling pathway
                                                        is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                        is-aER overload response +
                                                        is-aSREBP signaling pathway +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aER-nucleus signaling pathway
                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                        part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                is-aER overload response +
                                                is-aSREBP signaling pathway +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to topologically incorrect protein
                                                        is-acellular response to unfolded protein
                                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                        part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                                is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-acellular response to topologically incorrect protein
                                                is-acellular response to unfolded protein
                                                        is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                        is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-aresponse to endoplasmic reticulum stress
                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                        part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                is-aER overload response +
                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                part-ofnegative regulation of translation involved in response to endoplasmic reticulum stress
                                                is-aregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aER-nucleus signaling pathway
                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                        part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                is-aER overload response +
                                                is-aSREBP signaling pathway +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-acellular response to chemical stimulus
                                        is-acellular response to organic substance
                                                is-acellular response to topologically incorrect protein
                                                        is-acellular response to unfolded protein
                                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                        part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                                is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-aresponse to organic substance
                                        is-acellular response to organic substance
                                                is-acellular response to topologically incorrect protein
                                                        is-acellular response to unfolded protein
                                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                        part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                                is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-aresponse to organic substance
                                        is-aresponse to topologically incorrect protein
                                                is-acellular response to topologically incorrect protein
                                                        is-acellular response to unfolded protein
                                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                        part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                                is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-aresponse to organic substance
                                        is-aresponse to topologically incorrect protein
                                                is-aresponse to unfolded protein
                                                        is-acellular response to unfolded protein
                                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                        part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                                is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-acellular response to stress
                                        is-acellular response to topologically incorrect protein
                                                is-acellular response to unfolded protein
                                                        is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                        is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-acellular response to stress
                                        is-aresponse to endoplasmic reticulum stress
                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                        part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                is-aER overload response +
                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                part-ofnegative regulation of translation involved in response to endoplasmic reticulum stress
                                                is-aregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-aresponse to topologically incorrect protein
                                        is-acellular response to topologically incorrect protein
                                                is-acellular response to unfolded protein
                                                        is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                        is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-aresponse to topologically incorrect protein
                                        is-aresponse to unfolded protein
                                                is-acellular response to unfolded protein
                                                        is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                        is-amitochondrial unfolded protein response


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aER-nucleus signaling pathway
                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                        part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                is-aER overload response +
                                                is-aSREBP signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aER-nucleus signaling pathway
                                                is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                        part-ofactivation of signaling protein activity involved in unfolded protein response
                                                        negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                        positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                        regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                        part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                is-aER overload response +
                                                is-aSREBP signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aER-nucleus signaling pathway
                                                        is-aendoplasmic reticulum unfolded protein response [GO:0030968] (32 genes, 41 annotations)
                                                                part-ofactivation of signaling protein activity involved in unfolded protein response
                                                                negatively-regulatesnegative regulation of endoplasmic reticulum unfolded protein response
                                                                positively-regulatespositive regulation of endoplasmic reticulum unfolded protein response
                                                                part-ofpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
                                                                regulatesregulation of endoplasmic reticulum unfolded protein response +
                                                                part-ofUFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response
                                                        is-aER overload response +
                                                        is-aSREBP signaling pathway +


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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory