Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CASP9
  • Mouse genes Casp9
  • Rat genes Casp9
  • Zfish genes casp9
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Casp9

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CASP9	IDA		Human	PMID:16920334
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Casp9	IDA		Mouse	PMID:16183742
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	CASP9	IDA		Human	PMID:16352606
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	CASP9	IDA		Human	PMID:16916640
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	CASP9	IDA		Human	PMID:27889207
Molecular Function	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	CASP9	IDA		Human	PMID:16916640
Molecular Function	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	CASP9	IDA		Human	PMID:16920334
Molecular Function	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	CASP9	IMP		Human	PMID:21980415
Molecular Function	GO:0008234	cysteine-type peptidase activity	Casp9	IDA		Rat	PMID:16336964|RGD:2314393
Molecular Function	GO:0008234	cysteine-type peptidase activity	Casp9	IDA		Rat	PMID:18316105|RGD:2311460
Molecular Function	GO:0008233	peptidase activity	CASP9	IDA		Human	PMID:19740745
Molecular Function	GO:0008233	peptidase activity	CASP9	IDA		Human	PMID:20663920
Molecular Function	GO:0008233	peptidase activity	Casp9	IDA		Mouse	PMID:14561754
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:O14727	Human	PMID:10206961
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:O14727	Human	PMID:10376594
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q96CA5	Human	PMID:11024045
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:O15392-1	Human	PMID:11069302
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q13490	Human	PMID:11084335
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q96CA5	Human	PMID:11084335
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q8WU39-2	Human	PMID:11350957
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P98170	Human	PMID:11801603
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q96CA5	Human	PMID:11801603
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:O14727	Human	PMID:11821383
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q5EG05	Human	PMID:11821383
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P98170	Human	PMID:12620238
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P00519	Human	PMID:15657060
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P98170	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P43146	Human	PMID:16537496
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q13418	Human	PMID:16936772
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P98170	Human	PMID:18022362
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P42574	Human	PMID:18723680
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q13490	Human	PMID:19153467
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q9HD36	Human	PMID:19255499
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:O14727	Human	PMID:19494828
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P43146	Human	PMID:19721007
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:O14727	Human	PMID:20462491
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:O14727	Human	PMID:21827945
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q8XAL7	Human	PMID:23516580
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P42574	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P98170	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q13490	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P98170	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q13490	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q6PIA0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q96CA5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P98170	Human	PMID:25502805
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q8XAL7	Human	PMID:25519916
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P98170	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P98170	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P98170	Human	PMID:31467278
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P98170	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q13490	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q96CA5	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:P98170	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q13490	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:Q96CA5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CASP9	IPI	UniProtKB:O14727	Human	PMID:9922454
Molecular Function	GO:0005515	protein binding	Casp9	IPI	PR:P12815	Mouse	PMID:14561754
Molecular Function	GO:0005515	protein binding	Casp9	IPI	PR:Q01853	Mouse	PMID:14561754
Molecular Function	GO:0005515	protein binding	Casp9	IPI	RGD:620692	Rat	PMID:18485100|RGD:2314399
Molecular Function	GO:0019901	protein kinase binding	CASP9	IDA		Human	PMID:15657060
Molecular Function	GO:0017124	SH3 domain binding	CASP9	IDA		Human	PMID:15657060
Cellular Component	GO:0043293	apoptosome	CASP9	IPI		Human	PMID:10206961
Cellular Component	GO:0043293	apoptosome	CASP9	IDA		Human	PMID:21827945
Cellular Component	GO:0008303	caspase complex	CASP9	IPI		Human	PMID:11734640
Cellular Component	GO:0005737	cytoplasm	Casp9	IDA		Rat	PMID:11278518|RGD:62424
Cellular Component	GO:0005829	cytosol	CASP9	IDA		Human	PMID:17167422
Cellular Component	GO:0005829	cytosol	Casp9	IDA		Mouse	PMID:15271982
Cellular Component	GO:0005829	cytosol	Casp9	IDA		Rat	PMID:18316105|RGD:2311460
Cellular Component	GO:0005739	mitochondrion	CASP9	IDA		Human	PMID:12782307
Cellular Component	GO:0005739	mitochondrion	Casp9	IDA		Rat	PMID:18316105|RGD:2311460
Cellular Component	GO:0005634	nucleus	Casp9	IDA		Mouse	PMID:15271982
Cellular Component	GO:0005634	nucleus	Casp9	IDA		Rat	PMID:18316105|RGD:2311460
Cellular Component	GO:0032991	protein-containing complex	CASP9	IDA		Human	PMID:11821383
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	CASP9	IDA		Human	PMID:10206961
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	CASP9	IDA		Human	PMID:27882936
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	CASP9	IDA		Human	PMID:16916640
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Casp9	IMP	MGI:MGI:2158755	Mouse	PMID:15776018
Biological Process	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	CASP9	IDA		Human	PMID:10206961
Biological Process	GO:0007568	aging	Casp9	IEP		Rat	PMID:16139996|RGD:2311469
Biological Process	GO:0006915	apoptotic process	CASP9	IMP		Human	PMID:15069058
Biological Process	GO:0006915	apoptotic process	Casp9	IMP		Mouse	PMID:16469926
Biological Process	GO:0006915	apoptotic process	Casp9	IMP		Rat	PMID:18817839|RGD:2313963
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Casp9	IDA		Mouse	MGI:MGI:4456943|PMID:15944155
Biological Process	GO:0071407	cellular response to organic cyclic compound	Casp9	IEP		Rat	PMID:16987298|RGD:7240698
Biological Process	GO:0034644	cellular response to UV	CASP9	IDA		Human	PMID:15657060
Biological Process	GO:0006974	DNA damage response	CASP9	IDA		Human	PMID:15657060
Biological Process	GO:0006974	DNA damage response	CASP9	IMP		Human	PMID:15657060
Biological Process	GO:0006974	DNA damage response	Casp9	IMP	MGI:MGI:2158755	Mouse	PMID:11092819
Biological Process	GO:1904019	epithelial cell apoptotic process	Casp9	IDA		Mouse	PMID:17901126
Biological Process	GO:0044346	fibroblast apoptotic process	Casp9	IDA		Mouse	PMID:12847083
Biological Process	GO:0034349	glial cell apoptotic process	Casp9	IEP		Rat	PMID:18931364|RGD:2313998
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	CASP9	IDA		Human	PMID:35446120
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	CASP9	IMP		Human	PMID:15657060
Biological Process	GO:0001822	kidney development	Casp9	IEP		Rat	PMID:27665619|RGD:13703109
Biological Process	GO:0001822	kidney development	casp9	IMP	ZFIN:ZDB-MRPHLNO-080809-1	Zfish	PMID:22479191
Biological Process	GO:0071887	leukocyte apoptotic process	Casp9	IEP		Rat	PMID:26861981|RGD:13782282
Biological Process	GO:0051402	neuron apoptotic process	Casp9	IGI	MGI:MGI:99702	Mouse	PMID:11150333
Biological Process	GO:0051402	neuron apoptotic process	Casp9	IMP	MGI:MGI:2158755	Mouse	PMID:11150333
Biological Process	GO:0051402	neuron apoptotic process	Casp9	IMP	MGI:MGI:2158755	Mouse	PMID:11092819
Biological Process	GO:0043065	positive regulation of apoptotic process	CASP9	IMP		Human	PMID:11821383
Biological Process	GO:0043065	positive regulation of apoptotic process	Casp9	IMP		Rat	PMID:17869439|RGD:2314390
Biological Process	GO:0043065	positive regulation of apoptotic process	casp9	IDA		Zfish	PMID:16888647
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Casp9	IMP	MGI:MGI:2158755	Mouse	PMID:11150333
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Casp9	IMP	MGI:MGI:2158755	Mouse	PMID:11092819
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Casp9	IGI	MGI:MGI:99702	Mouse	PMID:11150333
Biological Process	GO:0051604	protein maturation	CASP9	IDA		Human	PMID:16352606
Biological Process	GO:0051604	protein maturation	CASP9	IDA		Human	PMID:16916640
Biological Process	GO:0016485	protein processing	Casp9	IDA		Rat	PMID:18316105|RGD:2311460
Biological Process	GO:0048696	regulation of collateral sprouting in absence of injury	casp9	IGI	ZFIN:ZDB-MRPHLNO-080809-1,ZFIN:ZDB-MRPHLNO-101025-4	Zfish	PMID:24385488
Biological Process	GO:0048696	regulation of collateral sprouting in absence of injury	casp9	IMP	ZFIN:ZDB-MRPHLNO-080809-1	Zfish	PMID:24385488
Biological Process	GO:0097205	renal filtration	casp9	IMP	ZFIN:ZDB-MRPHLNO-080809-1	Zfish	PMID:22479191
Biological Process	GO:0046677	response to antibiotic	Casp9	IEP		Rat	PMID:18595259|RGD:2311434
Biological Process	GO:0032025	response to cobalt ion	Casp9	IEP		Rat	PMID:18598848|RGD:2311433
Biological Process	GO:0032355	response to estradiol	Casp9	IEP		Rat	PMID:18598848|RGD:2311433
Biological Process	GO:0001666	response to hypoxia	Casp9	IEP		Rat	PMID:24089674|RGD:155882465
Biological Process	GO:0002931	response to ischemia	Casp9	IEP		Rat	PMID:11934844|RGD:13782263
Biological Process	GO:0032496	response to lipopolysaccharide	Casp9	IEP		Rat	PMID:18289516|RGD:2293323
Biological Process	GO:0014070	response to organic cyclic compound	Casp9	IDA		Rat	PMID:17297389|RGD:2315933
Biological Process	GO:0009411	response to UV	Casp9	IMP	MGI:MGI:2158755	Mouse	PMID:11092819
Biological Process	GO:0042770	signal transduction in response to DNA damage	CASP9	IDA		Human	PMID:15657060

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern