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Term Detail
GO term:cysteine-type endopeptidase activity
Synonym: caspase activity
Synonym: lysosomal cysteine-type endopeptidase
Synonym: metacaspase activity
Synonym: thiol endopeptidase activity
GO id:GO:0004197
Definition:Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-apeptidase activity
                                        is-apeptidase activity, acting on L-amino acid peptides
                                                is-acysteine-type peptidase activity
                                                        is-acysteine-type endopeptidase activity [GO:0004197] (60 genes, 86 annotations)
                                                                is-acalcium-dependent cysteine-type endopeptidase activity
                                                                is-acysteine-type endopeptidase activity involved in apoptotic process +
                                                                is-acysteine-type endopeptidase activity involved in plant-type hypersensitive response
                                                                is-asmall conjugating protein-specific endopeptidase activity +
                                                        is-acysteine-type exopeptidase activity +
                                                        is-asmall conjugating protein-specific protease activity +


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-ahydrolase activity
                                is-apeptidase activity
                                        is-apeptidase activity, acting on L-amino acid peptides
                                                is-aendopeptidase activity
                                                        is-aaspartic-type endopeptidase activity +
                                                        is-acysteine-type endopeptidase activity [GO:0004197] (60 genes, 86 annotations)
                                                                is-acalcium-dependent cysteine-type endopeptidase activity
                                                                is-acysteine-type endopeptidase activity involved in apoptotic process +
                                                                is-acysteine-type endopeptidase activity involved in plant-type hypersensitive response
                                                                is-asmall conjugating protein-specific endopeptidase activity +
                                                        is-aglutamic-type endopeptidase activity
                                                        is-ametalloendopeptidase activity +
                                                        is-aserine-type endopeptidase activity
                                                        is-athreonine-type endopeptidase activity


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory