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Casp9
Gene Detail
 Symbol
Name
ID
Casp9
caspase 9
MGI:1277950
Synonyms Caspase-9, ICE-LAP6, Mch6
Feature Type protein coding gene
Genetic Map
Chromosome 4
74.75 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:141793612-141815976 bp, + strand
From VEGA annotation of GRCm38

  22365 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31024  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: caspase, interleukin-1 beta convertase type
Gene Tree: Casp9

Human
homologs
Human Homolog CASP9, caspase 9, apoptosis-related cysteine peptidase
NCBI Gene ID 842
neXtProt AC  NX_P55211
Human Synonyms  APAF3, APAF-3, ICE-LAP6, MCH6, PPP1R56
Human Chr (Location)  1p36.21; chr1:15489723-15524912 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted mutants die perinatally with enlarged and malformed cerebrums caused by reduced apoptosis during brain development. Broad system- and stimulus-dependent effects are seen on apoptosis.
 
Interactions
Casp9 interacts with 236 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component apoptosome, cytoplasm, ...
Function cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (173)    Tissues (111)   
Theiler Stages: 2, 3, 10, 18, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 94
Northern blot 12
Western blot 31
RT-PCR 36
cDNA source data(33)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) Genomic(2) cDNA(35) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000009932 (Evidence)
Ensembl Gene ModelENSMUSG00000028914 (Evidence)
Entrez Gene12371 (Evidence)
UniGene88829
DFCITC1577151, TC1673435
DoTSDT.101254180, DT.101254987, DT.528266, DT.94038286, DT.99854483
NIA Mouse Gene IndexU005051
EC3.4.22.62
Consensus CDS ProjectCCDS18883.1, CCDS71510.1
International Mouse Knockout Project StatusCasp9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009932 VEGA Gene Model | MGI Sequence Detail 22365 C57BL/6J ±  kb
transcript OTTMUST00000023070 VEGA | MGI Sequence Detail 3897 Not Applicable 
polypeptide OTTMUSP00000010525 VEGA | MGI Sequence Detail 454 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(4) UniProt(8)
Polymorphisms SNPs within 2kb(529 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017350 Caspase, interleukin-1 beta convertase
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
InterPro IPR011600 Peptidase C14, caspase catalytic
InterPro IPR002138 Peptidase C14, caspase non-catalytic subunit p10
InterPro IPR015917 Peptidase C14, caspase precursor p45, core
InterPro IPR001309 Peptidase C14, ICE, catalytic subunit p20
InterPro IPR016129 Peptidase C14, ICE, catalytic subunit p20, active site
Protein Ontology PR:000002318 caspase-9
References (Earliest) J:47358 Sakamaki K, et al., Molecular cloning and characterization of mouse caspase-8. Eur J Biochem. 1998 Apr 15;253(2):399-405
(Latest) J:206578 Nonomura K, et al., Local apoptosis modulates early mammalian brain development through the elimination of morphogen-producing cells. Dev Cell. 2013 Dec 23;27(6):621-34
All references(128)
Other
accession IDs
MGI:2140188, MGI:2140578

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory