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Casp9 Gene Detail
Summary
  • Symbol
    Casp9
  • Name
    caspase 9
  • Synonyms
    Caspase-9, ICE-LAP6, Mch6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277950
    NCBI Gene: 12371
  • Gene Overview
    MyGene.info: CASP9
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:141793612-141815976 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 74.75 cM, cytoband E1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    502 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277950
protein coding gene Chr4:141793612-141815978 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029058
protein coding gene Chr4:144897950-144920323 (+)
A/J MGP_AJ_G0029018
protein coding gene Chr4:138577412-138599907 (+)
AKR/J MGP_AKRJ_G0028970
protein coding gene Chr4:142610190-142632631 (+)
BALB/cJ MGP_BALBcJ_G0029042
protein coding gene Chr4:139271973-139290598 (+)
C3H/HeJ MGP_C3HHeJ_G0028756
protein coding gene Chr4:142967037-142988655 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029483
protein coding gene Chr4:149936636-149958120 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026754
protein coding gene Chr4:131490505-131499572 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0028720
protein coding gene Chr4:154363775-154385200 (+)
DBA/2J MGP_DBA2J_G0028870
protein coding gene Chr4:138970485-138986653 (+)
FVB/NJ MGP_FVBNJ_G0028837
protein coding gene Chr4:138089094-138107626 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0028863
protein coding gene Chr4:158087728-158106355 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029521
protein coding gene Chr4:143125380-143153485 (+)
PWK/PhJ MGP_PWKPhJ_G0027909
protein coding gene Chr4:135868720-135885350 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027733
protein coding gene Chr4:138928123-138945668 (+)
WSB/EiJ MGP_WSBEiJ_G0028266
protein coding gene Chr4:143389313-143409575 (+)



Homology
more
  • Human Ortholog
    CASP9, caspase 9
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CASP9, caspase 9
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APAF3, APAF-3, ICE-LAP6, MCH6, PPP1R56
  • Links
    NCBI Gene ID: 842
    neXtProt AC: NX_P55211
    UniProt: P55211

  • Chr Location
    1p36.21; chr1:15491401-15524912 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous targeted mutants die perinatally with enlarged and malformed cerebrums caused by reduced apoptosis during brain development. Broad system- and stimulus-dependent effects are seen on apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028914 Ensembl Gene Model | MGI Sequence Detail 22365 C57BL/6J ±  kb
    transcript ENSMUST00000030747 Ensembl | MGI Sequence Detail 3897 Not Applicable  
    polypeptide ENSMUSP00000030747 Ensembl | MGI Sequence Detail 454 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 2
      cDNA 36
      Primer pair 3
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2140188, MGI:2140578
    References
    more
    • Summaries
      All 150
      Developmental Gene Expression 36
      Gene Ontology 19
      Phenotypes 40
    • Earliest
      J:47358 Sakamaki K, et al., Molecular cloning and characterization of mouse caspase-8. Eur J Biochem. 1998 Apr 15;253(2):399-405
    • Latest
      J:262835 Ke FFS, et al., Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK. Cell. 2018 May 17;173(5):1217-1230.e17

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory