Casp9 MGI Mouse Gene Detail - MGI:1277950

Symbol

Casp9
Name

caspase 9
Synonyms

Caspase-9, ICE-LAP6, Mch6

Feature Type

protein coding gene
IDs

MGI:1277950
NCBI Gene: 12371
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:141520923-141543287 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 74.75 cM, cytoband E1
Mapping Data

4 experiments

SNPs within 2kb

1145 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277950	protein coding gene	Chr4:141520923-141543289 (+)
129S1/SvImJ	ENSMUSG00200042130	protein coding gene	Chr4:134943678-134968405 (+)
A/J	ENSMUSG00195031442	protein coding gene	Chr4:136290817-136315537 (+)
AKR/J	ENSMUSG00220047834	protein coding gene	Chr4:135291536-135318314 (+)
BALB/cJ	ENSMUSG00180039462	protein coding gene	Chr4:133931701-133958484 (+)
C3H/HeJ	ENSMUSG00175034198	protein coding gene	Chr4:134958266-134985050 (+)
C57BL/6NJ	ENSMUSG00215048085	protein coding gene	Chr4:136473413-136498127 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026754	protein coding gene	Chr4:131490505-131499572 (+)
CAST/EiJ	ENSTCUG00005012674	protein coding gene	Chr4:135918505-135944916 (+)
CBA/J	ENSMUSG00210026982	protein coding gene	Chr4:134582197-134608973 (+)
DBA/2J	ENSMUSG00185051179	protein coding gene	Chr4:136090711-136110801 (+)
FVB/NJ	ENSMUSG00205025327	protein coding gene	Chr4:134340636-134365355 (+)
JF1/MsJ	ENSUMUG00000032456	protein coding gene	Chr4:136780210-136807031 (+)
LP/J	ENSMUSG00230039015	protein coding gene	Chr4:139882123-139906847 (+)
NOD/ShiLtJ	ENSMUSG00190028471	protein coding gene	Chr4:134336099-134360813 (+)
NZO/HlLtJ	ENSMUSG00225009533	protein coding gene	Chr4:145829023-145855445 (+)
PWK/PhJ	ENSLUMG00010039123	protein coding gene	Chr4:133776143-133796233 (+)
SPRET/EiJ	ENSMSPG00010029055	protein coding gene	Chr4:135818255-135838278 (+)
WSB/EiJ	ENSIUOG00005045470	protein coding gene	Chr4:134224058-134250486 (+)

Human Ortholog

CASP9, caspase 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CASP9, caspase 9
Synonyms

APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56
Links

HGNC:1511

NCBI Gene ID: 842

UniProt: P55211
Chr Location

1p36.21; chr1:15490832-15526534 (-) GRCh38

MGI Vertebrate Homology

Casp9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CASP9
Protein SuperFamily

Caspase_ICE
Gene Tree

Casp9

Diseases

6 with human CASP9 associations

				Human Disease	Mouse Models
				colorectal cancer IDs colorectal cancer DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				pancreatic cancer IDs pancreatic cancer DOID:1793 DOID:14356 DOID:1797 DOID:3588 DOID:9859 ICD10CM:C25.0 ICD10CM:C25.1 ICD10CM:C25.2 ICD9CM:157.0 ICD9CM:157.1 ICD9CM:157.2 ICD9CM:157.8 KEGG:05212 MESH:D010190 NCI:C194089 NCI:C194090 NCI:C194091 NCI:C3305 ORDO:1333 ORDO:217074 UMLS_CUI:C0030297 UMLS_CUI:C0153458 UMLS_CUI:C0153459 UMLS_CUI:C0153460 UMLS_CUI:C0153463
				Parkinson's disease IDs Parkinson's disease DOID:14330 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 UMLS_CUI:C0030567
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

42 phenotypes from 2 alleles in 3 genetic backgrounds
9 phenotypes from multigenic genotypes
52 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

2
Targeted

6
Genomic Mutations

3 involving Casp9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous targeted mutants die perinatally with enlarged and malformed cerebrums caused by reduced apoptosis during brain development. Broad system- and stimulus-dependent effects are seen on apoptosis.

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All GO Annotations

93
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

843
Tissues

133
cDNA Data

34
Literature Summary

46

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase casp9

ZFIN casp9

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All Sequences

65
RefSeq

10
UniProt

8
CCDS

CCDS18883.1, CCDS71510.1

Ensembl

ENSMUSG00000028914 (Evidence)
NCBI Gene

12371

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028914	Ensembl Gene Model \| MGI Sequence Detail	22365	C57BL/6J	± kb
transcript	ENSMUST00000030747	Ensembl \| MGI Sequence Detail	3897	Not Applicable
polypeptide	ENSMUSP00000030747	Ensembl \| MGI Sequence Detail	454	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000002318 caspase-9

(term hierarchy)
EC

3.4.22.62
InterPro Domains

IPR001315 CARD domain

IPR042147 CASP9, CARD domain

IPR029030 Caspase-like domain superfamily

IPR037939 Death domain-containing protein CRADD

IPR011029 Death-like domain superfamily

IPR015917 Peptidase C14A, caspase catalytic domain

IPR011600 Peptidase C14, caspase domain

IPR002138 Peptidase C14, caspase non-catalytic subunit p10

IPR002398 Peptidase C14 family

IPR001309 Peptidase C14, p20 domain

IPR033139 Peptidase family C14A, cysteine active site

IPR016129 Peptidase family C14A, His active site
GlyGen

Q8C3Q9 2 sites, 1 O-linked glycan (1 site)

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All nucleic 44

Genomic 2

cDNA 36

Primer pair 5

Other 1

Antibodies 9

Microarray probesets 7

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MGI:2140188, MGI:2140578

Summaries

All 280

Developmental Gene Expression 46

Gene Ontology 18

Phenotypes 52
Earliest

J:47358 Sakamaki K, et al., Molecular cloning and characterization of mouse caspase-8. Eur J Biochem. 1998 Apr 15;253(2):399-405
Latest

J:377026 Deng Q, et al., N-terminal alpha-amino SUMOylation promotes phosphorylation-independent cofilin-1 translocation to the mitochondrial matrix and induces apoptosis. Nat Commun. 2025 Nov 27;16(1):11687

TSS for Casp9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40099	Chr4:141521016-141521046 (+)	108 bp
Tssr40100	Chr4:141521100-141521120 (+)	187 bp
Tssr40101	Chr4:141521129-141521159 (+)	221 bp
Tssr40102	Chr4:141542268-141542282 (+)	21,352 bp
Tssr40103	Chr4:141542293-141542298 (+)	21,373 bp
Tssr40104	Chr4:141542306-141542344 (+)	21,402 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24