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Casp9 Gene Detail
Summary
  • Symbol
    Casp9
  • Name
    caspase 9
  • Synonyms
    Caspase-9, ICE-LAP6, Mch6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277950
    NCBI Gene: 12371
  • Gene Overview
    MyGene.info: CASP9
Location & Maps
more
  • Sequence Map
    Chr4:141793612-141815976 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22365 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 74.75 cM, cytoband E1
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CASP9, caspase 9
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CASP9, caspase 9
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APAF3, APAF-3, ICE-LAP6, MCH6, PPP1R56
  • Links
    NCBI Gene ID: 842
    neXtProt AC: NX_P55211

  • Chr Location
    1p36.21; chr1:15491401-15526529 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Targeted
    6
  • Genomic Mutations
    3 involving Casp9
  • Incidental Mutations
Homozygous targeted mutants die perinatally with enlarged and malformed cerebrums caused by reduced apoptosis during brain development. Broad system- and stimulus-dependent effects are seen on apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009932 VEGA Gene Model | MGI Sequence Detail 22365 C57BL/6J ±  kb
transcript OTTMUST00000023070 VEGA | MGI Sequence Detail 3897 Not Applicable  
polypeptide OTTMUSP00000010525 VEGA | MGI Sequence Detail 454 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    502 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 40
    Genomic 2
    cDNA 35
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
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MGI:2140188, MGI:2140578
References
more
  • Summaries
    All 134
    Developmental Gene Expression 31
    Gene Ontology 18
    Phenotypes 40
  • Earliest
    J:47358 Sakamaki K, et al., Molecular cloning and characterization of mouse caspase-8. Eur J Biochem. 1998 Apr 15;253(2):399-405
  • Latest
    J:229013 Liu ES, et al., c-Raf promotes angiogenesis during normal growth plate maturation. Development. 2016 Jan 15;143(2):348-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory