Casp9
Gene Detail

Symbol Name ID

Casp9 caspase 9 MGI:1277950

Synonyms

Caspase-9, ICE-LAP6, Mch6

Feature Type

protein coding gene

Genetic Map

Chromosome 4

74.75 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr4:141793612-141815976 bp, + strand From VEGA annotation of GRCm38   22365 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31024  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: caspase, interleukin-1 beta convertase type
Gene Tree: Casp9

Human homologs

Human Homolog		CASP9, caspase 9, apoptosis-related cysteine peptidase
NCBI Gene ID		842
neXtProt AC		NX_P55211
Human Synonyms		APAF3, APAF-3, CASPASE-9c, ICE-LAP6, MCH6, PPP1R56
Human Chr (Location)		1p36.21; chr1:15818769-15851285 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Homozygous targeted mutants die perinatally with enlarged and malformed cerebrums caused by reduced apoptosis during brain development. Broad system- and stimulus-dependent effects are seen on apoptosis.

 

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component	apoptosome, cytoplasm, ...
Function	cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (25 records)
Data Summary: Results (173)    Tissues (111)   
Theiler Stages: 2, 3, 10, 18, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	94
Northern blot	12
Western blot	31
RT-PCR	36

cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(2) cDNA(13) Primer pair(3)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000009932 (Evidence)
Ensembl Gene Model	ENSMUSG00000028914 (Evidence)
Entrez Gene	12371 (Evidence)
DFCI	TC1577151, TC1673435
DoTS	DT.101254180, DT.101254987, DT.528266, DT.94038286, DT.99854483
NIA Mouse Gene Index	U005051
EC	3.4.22.62
Consensus CDS Project	CCDS18883.1
International Mouse Knockout Project Status	Casp9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009932	VEGA Gene Model | MGI Sequence Detail	22365	C57BL/6J
transcript	OTTMUST00000023070	VEGA | MGI Sequence Detail	3897	Not Applicable
polypeptide	OTTMUSP00000010525	VEGA | MGI Sequence Detail	454	Not Applicable

All sequences(58) RefSeq(4) UniProt(9)

Polymorphisms

SNPs(333 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017350	Caspase, interleukin-1 beta convertase
InterPro	IPR001315	Caspase Recruitment
InterPro	IPR011029	DEATH-like
InterPro	IPR011600	Peptidase C14, caspase catalytic
InterPro	IPR002138	Peptidase C14, caspase non-catalytic subunit p10
InterPro	IPR002398	Peptidase C14, caspase precursor p45
InterPro	IPR015917	Peptidase C14, caspase precursor p45, core
InterPro	IPR001309	Peptidase C14, ICE, catalytic subunit p20
InterPro	IPR016129	Peptidase C14, ICE, catalytic subunit p20, active site
Protein Ontology	PR:000002318	caspase-9

References

(Earliest) J:47358 Sakamaki K, et al., Molecular cloning and characterization of mouse caspase-8. Eur J Biochem. 1998 Apr 15;253(2):399-405
(Latest) J:193196 Simon DJ, et al., A caspase cascade regulating developmental axon degeneration. J Neurosci. 2012 Dec 5;32(49):17540-53
All references(121)

Other accession IDs

MGI:2140188, MGI:2140578