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Casp9
Gene Detail
Symbol

Name
ID
Casp9
caspase 9
MGI:1277950
Synonyms
Caspase-9, ICE-LAP6, Mch6
Feature Type
protein coding gene
Genetic Map
Chromosome 4
74.75 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:141793612-141815976 bp, + strand
From VEGA annotation of GRCm38

  22365 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31024  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: CASP9
Protein SuperFamily: caspase, interleukin-1 beta convertase type
Gene Tree: Casp9

Human
homologs
CASP9, caspase 9, apoptosis-related cysteine peptidase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 842
neXtProt AC: NX_P55211

Human Synonyms: APAF3, APAF-3, ICE-LAP6, MCH6, PPP1R56

Human Chr (Location): 1p36.21; chr1:15491401-15526529 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Genomic Mutations involving Casp9 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted mutants die perinatally with enlarged and malformed cerebrums caused by reduced apoptosis during brain development. Broad system- and stimulus-dependent effects are seen on apoptosis.
 
Interactions
Casp9 interacts with 235 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (30 records)
Data Summary: Results (173)    Tissues (111)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 12
Western blot 31
RT-PCR 36
cDNA source data(33)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase casp9 ; ZFIN casp9    NEW 
Molecular
reagents
All nucleic(40) Genomic(2) cDNA(35) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000009932 (Evidence)
Ensembl Gene Model ENSMUSG00000028914 (Evidence)
Entrez Gene 12371 (Evidence)
UniGene 88829
DFCI TC1577151, TC1673435
DoTS DT.101254180, DT.101254987, DT.528266, DT.94038286, DT.99854483
NIA Mouse Gene Index U005051
EC 3.4.22.62
Consensus CDS Project CCDS18883.1, CCDS71510.1
International Mouse Phenotyping Consortium Status Casp9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009932 VEGA Gene Model | MGI Sequence Detail 22365 C57BL/6J ±  kb
transcript OTTMUST00000023070 VEGA | MGI Sequence Detail 3897 Not Applicable 
polypeptide OTTMUSP00000010525 VEGA | MGI Sequence Detail 454 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(4) UniProt(8)
Polymorphisms
SNPs within 2kb(529 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017350 Caspase, interleukin-1 beta convertase
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
InterPro IPR011600 Peptidase C14, caspase catalytic
InterPro IPR002138 Peptidase C14, caspase non-catalytic subunit p10
InterPro IPR015917 Peptidase C14, caspase precursor p45, core
InterPro IPR001309 Peptidase C14, ICE, catalytic subunit p20
InterPro IPR016129 Peptidase C14, ICE, catalytic subunit p20, active site
Protein Ontology PR:000002318 caspase-9
References
(Earliest) J:47358 Sakamaki K, et al., Molecular cloning and characterization of mouse caspase-8. Eur J Biochem. 1998 Apr 15;253(2):399-405
(Latest) J:218093 Aoto K, et al., Co-ordinated brain and craniofacial development depend upon Patched1/XIAP regulation of cell survival. Hum Mol Genet. 2015 Feb 1;24(3):698-713
All references(134)
Other
accession IDs
MGI:2140188, MGI:2140578

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory