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Gene Ontology Browser
Term Detail
GO term:apoptotic process
Synonym: activation of apoptosis
Synonym: apoptosis
Synonym: apoptosis activator activity
Synonym: apoptosis signaling
Synonym: apoptotic cell death
Synonym: apoptotic program
Synonym: apoptotic programmed cell death
Synonym: cell suicide
Synonym: cellular suicide
Synonym: commitment to apoptosis
Synonym: induction of apoptosis
Synonym: induction of apoptosis by p53
Synonym: programmed cell death by apoptosis
Synonym: signaling (initiator) caspase activity
Synonym: type I programmed cell death
GO id:GO:0006915
Definition:A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
Number of paths to term: 3

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process [GO:0006915] (1539 genes, 3478 annotations)
                                                        part-ofactivation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        is-aanoikis +
                                                        part-ofapoptotic mitochondrial changes +
                                                        is-aapoptotic process involved in development +
                                                        part-ofapoptotic signaling pathway +
                                                        is-acell-type specific apoptotic process +
                                                        part-ofexecution phase of apoptosis +
                                                        negatively-regulatesnegative regulation of apoptotic process +
                                                        part-ofnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofnegative regulation of mitochondrial membrane permeability involved in apoptotic process
                                                        positively-regulatespositive regulation of apoptotic process +
                                                        part-ofpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofpositive regulation of mitochondrial membrane permeability involved in apoptotic process +
                                                        regulatesregulation of apoptotic process +
                                                        part-ofregulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofregulation of mitochondrial membrane permeability involved in apoptotic process +
                                                is-aautophagic cell death +
                                                is-acornification
                                                is-adevelopmental programmed cell death +
                                                is-ahost programmed cell death induced by symbiont +
                                                part-ofmitochondrial outer membrane permeabilization involved in programmed cell death +
                                                negatively-regulatesnegative regulation of programmed cell death +
                                                positively-regulatespositive regulation of programmed cell death +
                                                is-aprogrammed cell death in response to reactive oxygen species +
                                                is-aprogrammed necrotic cell death +
                                                is-apyroptosis
                                                regulatesregulation of programmed cell death +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-adeath
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process [GO:0006915] (1539 genes, 3478 annotations)
                                                        part-ofactivation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        is-aanoikis +
                                                        part-ofapoptotic mitochondrial changes +
                                                        is-aapoptotic process involved in development +
                                                        part-ofapoptotic signaling pathway +
                                                        is-acell-type specific apoptotic process +
                                                        part-ofexecution phase of apoptosis +
                                                        negatively-regulatesnegative regulation of apoptotic process +
                                                        part-ofnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofnegative regulation of mitochondrial membrane permeability involved in apoptotic process
                                                        positively-regulatespositive regulation of apoptotic process +
                                                        part-ofpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofpositive regulation of mitochondrial membrane permeability involved in apoptotic process +
                                                        regulatesregulation of apoptotic process +
                                                        part-ofregulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofregulation of mitochondrial membrane permeability involved in apoptotic process +
                                                is-aautophagic cell death +
                                                is-acornification
                                                is-adevelopmental programmed cell death +
                                                is-ahost programmed cell death induced by symbiont +
                                                part-ofmitochondrial outer membrane permeabilization involved in programmed cell death +
                                                negatively-regulatesnegative regulation of programmed cell death +
                                                positively-regulatespositive regulation of programmed cell death +
                                                is-aprogrammed cell death in response to reactive oxygen species +
                                                is-aprogrammed necrotic cell death +
                                                is-apyroptosis
                                                regulatesregulation of programmed cell death +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process [GO:0006915] (1539 genes, 3478 annotations)
                                                        part-ofactivation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        is-aanoikis +
                                                        part-ofapoptotic mitochondrial changes +
                                                        is-aapoptotic process involved in development +
                                                        part-ofapoptotic signaling pathway +
                                                        is-acell-type specific apoptotic process +
                                                        part-ofexecution phase of apoptosis +
                                                        negatively-regulatesnegative regulation of apoptotic process +
                                                        part-ofnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofnegative regulation of mitochondrial membrane permeability involved in apoptotic process
                                                        positively-regulatespositive regulation of apoptotic process +
                                                        part-ofpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofpositive regulation of mitochondrial membrane permeability involved in apoptotic process +
                                                        regulatesregulation of apoptotic process +
                                                        part-ofregulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofregulation of mitochondrial membrane permeability involved in apoptotic process +
                                                is-aautophagic cell death +
                                                is-acornification
                                                is-adevelopmental programmed cell death +
                                                is-ahost programmed cell death induced by symbiont +
                                                part-ofmitochondrial outer membrane permeabilization involved in programmed cell death +
                                                negatively-regulatesnegative regulation of programmed cell death +
                                                positively-regulatespositive regulation of programmed cell death +
                                                is-aprogrammed cell death in response to reactive oxygen species +
                                                is-aprogrammed necrotic cell death +
                                                is-apyroptosis
                                                regulatesregulation of programmed cell death +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory