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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Agt

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Agt
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0005179hormone activityAGTIDAHumanPMID:1567413
Molecular FunctionGO:0005179hormone activityAgtIDARatPMID:8348686|RGD:8553767
Molecular FunctionGO:0005515protein bindingAGTIPIUniProtKB:P0C045HumanPMID:16237761
Molecular FunctionGO:0005515protein bindingAGTIPIUniProtKB:P25095HumanPMID:18202720
Molecular FunctionGO:0005515protein bindingAGTIPIUniProtKB:P00797HumanPMID:20927107
Molecular FunctionGO:0005515protein bindingAGTIPIUniProtKB:Q10714HumanPMID:23082758
Molecular FunctionGO:0005515protein bindingAGTIPIUniProtKB:C9J082HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingAGTIPIUniProtKB:O00746HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingAGTIPIUniProtKB:O14744HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingAGTIPIUniProtKB:O43493-5HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingAGTIPIUniProtKB:Q8IYM2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingAGTIPIUniProtKB:Q8N0U8HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingAGTIPIUniProtKB:Q8NFB2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingAGTIPIUniProtKB:Q8TAB7HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingAGTIPIUniProtKB:Q8TAS3HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingAGTIPIUniProtKB:Q9UI10HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingAGTIPIUniProtKB:Q9UMY4HumanPMID:32814053
Molecular FunctionGO:0031702type 1 angiotensin receptor bindingAGTIPIUniProtKB:P30556HumanPMID:1378723
Molecular FunctionGO:0031702type 1 angiotensin receptor bindingAgtIDAMousePMID:9878677
Molecular FunctionGO:0031703type 2 angiotensin receptor bindingAGTIPIUniProtKB:P50052HumanPMID:10406457
Molecular FunctionGO:0031703type 2 angiotensin receptor bindingAgtIPIPR:P35374MousePMID:9878677
Cellular ComponentGO:0072562blood microparticleAGTHDAHumanPMID:22516433
Cellular ComponentGO:0062023collagen-containing extracellular matrixAGTHDAHumanPMID:25037231
Cellular ComponentGO:0005737cytoplasmAgtIDARatPMID:12242043|RGD:1581651
Cellular ComponentGO:0070062extracellular exosomeAGTHDAHumanPMID:23533145
Cellular ComponentGO:0005576extracellular regionAGTHDAHumanPMID:27068509
Cellular ComponentGO:0005615extracellular spaceAGTIDAHumanPMID:4300938
Cellular ComponentGO:0005615extracellular spaceAGTHDAHumanPMID:16502470
Cellular ComponentGO:0005615extracellular spaceAGTIDAHumanPMID:18971559
Cellular ComponentGO:0005615extracellular spaceAgtIDAMousePMID:11606482
Cellular ComponentGO:0005615extracellular spaceAgtIDAMousePMID:7989296
Cellular ComponentGO:0005615extracellular spaceAgtIDAMousePMID:10425188
Cellular ComponentGO:0005615extracellular spaceAgtIDARatPMID:12242043|RGD:1581651
Cellular ComponentGO:0005615extracellular spaceAgtIDARatPMID:8252633|RGD:8553951
Biological ProcessGO:0007250activation of NF-kappaB-inducing kinase activityAgtIDAMousePMID:19404405
Biological ProcessGO:0007202activation of phospholipase C activityAgtIMPRatPMID:11100981|RGD:1582152
Biological ProcessGO:0007568agingAgtIEPRatPMID:21318332|RGD:5129178
Biological ProcessGO:0035932aldosterone secretionAgtIMPMousePMID:22550170
Biological ProcessGO:0035932aldosterone secretionAgtIMPMGI:MGI:2136636MousePMID:9557921
Biological ProcessGO:0003051angiotensin-mediated drinking behaviorAgtIDARatPMID:21281609|RGD:5129187
Biological ProcessGO:0003051angiotensin-mediated drinking behaviorAgtIMPRatPMID:9622148|RGD:8549458
Biological ProcessGO:0001998angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressureAgtIDAMousePMID:10425188
Biological ProcessGO:0014824artery smooth muscle contractionAgtIDARatPMID:21076237|RGD:5129195
Biological ProcessGO:0008306associative learningAgtIDARatPMID:15245880|RGD:1581389
Biological ProcessGO:0048143astrocyte activationAgtIMPMGI:MGI:2136636MousePMID:9734405
Biological ProcessGO:0001568blood vessel developmentAgtIMPMGI:MGI:2183545MousePMID:8675666
Biological ProcessGO:0001568blood vessel developmentAgtIMPMGI:MGI:2183545MousePMID:9466969
Biological ProcessGO:0002035brain renin-angiotensin systemAgtIDAMousePMID:15499027
Biological ProcessGO:0002035brain renin-angiotensin systemAgtIDAMousePMID:9878677
Biological ProcessGO:0001658branching involved in ureteric bud morphogenesisAgtIDAMousePMID:12657564
Biological ProcessGO:0061049cell growth involved in cardiac muscle cell developmentAgtIDARatPMID:21376054|RGD:5129173
Biological ProcessGO:0008283cell population proliferationAgtIMPMousePMID:11606482
Biological ProcessGO:0008283cell population proliferationAgtIMPMGI:MGI:2183545MousePMID:8675666
Biological ProcessGO:0008283cell population proliferationAgtIMPMGI:MGI:1857121MousePMID:10318840
Biological ProcessGO:0007166cell surface receptor signaling pathwayAgtIDARatPMID:12130563|RGD:625718
Biological ProcessGO:0007160cell-matrix adhesionAgtIMPMGI:MGI:2136636MousePMID:9734405
Biological ProcessGO:1904385cellular response to angiotensinAgtIEPRatPMID:24431199|RGD:13432364
Biological ProcessGO:0071260cellular response to mechanical stimulusAgtIEPRatPMID:21131638|RGD:5129192
Biological ProcessGO:0042756drinking behaviorAgtIMPMGI:MGI:2136636MousePMID:9852267
Biological ProcessGO:0070371ERK1 and ERK2 cascadeAgtIDARatPMID:21367774|RGD:5129174
Biological ProcessGO:0008065establishment of blood-nerve barrierAgtIMPMGI:MGI:2136636MousePMID:9734405
Biological ProcessGO:0030198extracellular matrix organizationAgtIMPMGI:MGI:2136636MousePMID:9734405
Biological ProcessGO:0007565female pregnancyAgtIEPRatPMID:17977916|RGD:8548898
Biological ProcessGO:0048144fibroblast proliferationAgtIDARatPMID:21419085|RGD:5129171
Biological ProcessGO:0007186G protein-coupled receptor signaling pathwayAGTIDAHumanPMID:10406457
Biological ProcessGO:0007186G protein-coupled receptor signaling pathwayAgtIMPRatPMID:16286564|RGD:1582434
Biological ProcessGO:0042445hormone metabolic processAgtIMPMGI:MGI:2136636MousePMID:12660889
Biological ProcessGO:0006883intracellular sodium ion homeostasisAgtIMPRatPMID:16380540|RGD:1582118
Biological ProcessGO:0001822kidney developmentAGTIMPHumanPMID:16116425
Biological ProcessGO:0001822kidney developmentAgtIMPMGI:MGI:2183545MousePMID:9466969
Biological ProcessGO:0001822kidney developmentAgtIMPMGI:MGI:2183545MousePMID:8675666
Biological ProcessGO:0002034maintenance of blood vessel diameter homeostasis by renin-angiotensinAGTIDAHumanPMID:1567413
Biological ProcessGO:0000165MAPK cascadeAgtIMPMGI:MGI:2136636MousePMID:9196031
Biological ProcessGO:0016525negative regulation of angiogenesisAgtIDARatPMID:21281454|RGD:5129188
Biological ProcessGO:0030308negative regulation of cell growthAgtIMPRatPMID:15951342|RGD:1581938
Biological ProcessGO:0008285negative regulation of cell population proliferationAgtIMPMousePMID:11606482
Biological ProcessGO:0043407negative regulation of MAP kinase activityAGTIMPHumanPMID:28283184
Biological ProcessGO:0043524negative regulation of neuron apoptotic processAgtIMPMGI:MGI:2136636MousePMID:9310306
Biological ProcessGO:0051387negative regulation of neurotrophin TRK receptor signaling pathwayAGTIDAHumanPMID:10406457
Biological ProcessGO:0048662negative regulation of smooth muscle cell proliferationAgtIMPMGI:MGI:2183545MousePMID:8675666
Biological ProcessGO:0048662negative regulation of smooth muscle cell proliferationAgtIMPMGI:MGI:1857121MousePMID:10318840
Biological ProcessGO:0034104negative regulation of tissue remodelingAgtIDARatPMID:21167013|RGD:5129191
Biological ProcessGO:1904706negative regulation of vascular associated smooth muscle cell proliferationAgtIMPMGI:MGI:2183545MousePMID:8675666
Biological ProcessGO:0051402neuron apoptotic processAgtIMPMGI:MGI:2136636MousePMID:9310306
Biological ProcessGO:0035106operant conditioningAgtIDARatPMID:15245880|RGD:1581389
Biological ProcessGO:0035265organ growthAgtIDAMousePMID:16374517
Biological ProcessGO:0001543ovarian follicle ruptureAgtIMPMGI:MGI:1857122MousePMID:11384650
Biological ProcessGO:0030432peristalsisAgtIMPMGI:MGI:2183545MousePMID:9788961
Biological ProcessGO:0010536positive regulation of activation of Janus kinase activityAGTIMPHumanPMID:15153556
Biological ProcessGO:0045777positive regulation of blood pressureAgtIDARatPMID:11897768|RGD:70484
Biological ProcessGO:0045777positive regulation of blood pressureAgtIDARatPMID:21318332|RGD:5129178
Biological ProcessGO:0090190positive regulation of branching involved in ureteric bud morphogenesisAGTIDAHumanPMID:18607644
Biological ProcessGO:0010666positive regulation of cardiac muscle cell apoptotic processAgtIDARatPMID:24465706|RGD:11039412
Biological ProcessGO:0010613positive regulation of cardiac muscle hypertrophyAgtIDARatPMID:8348686|RGD:8553767
Biological ProcessGO:0043085positive regulation of catalytic activityAgtIMPRatPMID:11100981|RGD:1582152
Biological ProcessGO:0008284positive regulation of cell population proliferationAgtIDARatPMID:22561449|RGD:8549484
Biological ProcessGO:1905920positive regulation of CoA-transferase activityAGTIDAHumanPMID:18971559
Biological ProcessGO:0001819positive regulation of cytokine productionAgtIMPMouseMGI:MGI:4420536|PMID:19023134
Biological ProcessGO:0007204positive regulation of cytosolic calcium ion concentrationAgtIDARatPMID:24036592|RGD:11039031
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionAGTIDAHumanPMID:15153556
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionAGTIDAHumanPMID:18607644
Biological ProcessGO:0010595positive regulation of endothelial cell migrationAGTIDAHumanPMID:15652490
Biological ProcessGO:0045742positive regulation of epidermal growth factor receptor signaling pathwayAGTIDAHumanPMID:15652490
Biological ProcessGO:0003331positive regulation of extracellular matrix constituent secretionAgtIDARatPMID:21419085|RGD:5129171
Biological ProcessGO:2001238positive regulation of extrinsic apoptotic signaling pathwayAGTIDAHumanPMID:10406457
Biological ProcessGO:0045723positive regulation of fatty acid biosynthetic processAgtIMPMousePMID:11606482
Biological ProcessGO:0048146positive regulation of fibroblast proliferationAgtIDARatPMID:8348686|RGD:8553767
Biological ProcessGO:1903598positive regulation of gap junction assemblyAGTIGIUniProtKB:P00797HumanPMID:17416596
Biological ProcessGO:0010628positive regulation of gene expressionAgtIDAMousePMID:19404405
Biological ProcessGO:0046628positive regulation of insulin receptor signaling pathwayAgtIDARatPMID:24184594|RGD:11039409
Biological ProcessGO:1905589positive regulation of L-arginine import across plasma membraneAgtIDARatPMID:7499219|RGD:11039060
Biological ProcessGO:1905010positive regulation of L-lysine import across plasma membraneAgtIDARatPMID:7499219|RGD:11039060
Biological ProcessGO:0010744positive regulation of macrophage derived foam cell differentiationAGTIDAHumanPMID:18971559
Biological ProcessGO:0043410positive regulation of MAPK cascadeAgtIMPMGI:MGI:2136636MousePMID:9196031
Biological ProcessGO:0040018positive regulation of multicellular organism growthAgtIMPMGI:MGI:2136636MousePMID:12660889
Biological ProcessGO:0010976positive regulation of neuron projection developmentAgtIMPRatPMID:18388195|RGD:13432362
Biological ProcessGO:0045429positive regulation of nitric oxide biosynthetic processAgtIDARatPMID:17616753|RGD:8548892
Biological ProcessGO:0046622positive regulation of organ growthAgtIDAMousePMID:16374517
Biological ProcessGO:0046622positive regulation of organ growthAgtIMPMGI:MGI:2136636MousePMID:12660889
Biological ProcessGO:0033138positive regulation of peptidyl-serine phosphorylationAgtIDAMousePMID:23775122
Biological ProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationAGTIDAHumanPMID:15652490
Biological ProcessGO:0014068positive regulation of phosphatidylinositol 3-kinase signalingAGTIDAHumanPMID:15652490
Biological ProcessGO:1900020positive regulation of protein kinase C activityAgtIDAMousePMID:23775122
Biological ProcessGO:0051247positive regulation of protein metabolic processAGTIDAHumanPMID:18971559
Biological ProcessGO:0061098positive regulation of protein tyrosine kinase activityAGTIMPHumanPMID:15153556
Biological ProcessGO:0035815positive regulation of renal sodium excretionAgtIMPRatPMID:16380540|RGD:1582118
Biological ProcessGO:0035815positive regulation of renal sodium excretionAgtIDARatPMID:22689743|RGD:8549474
Biological ProcessGO:0032930positive regulation of superoxide anion generationAgtIDARatPMID:21376054|RGD:5129173
Biological ProcessGO:1904754positive regulation of vascular associated smooth muscle cell migrationAgtIDARatPMID:24595849|RGD:11039416
Biological ProcessGO:1904707positive regulation of vascular associated smooth muscle cell proliferationAgtIDARatPMID:24595849|RGD:11039416
Biological ProcessGO:0006606protein import into nucleusAgtIDARatPMID:21376054|RGD:5129173
Biological ProcessGO:0042981regulation of apoptotic processAgtIDAMousePMID:19404405
Biological ProcessGO:0042981regulation of apoptotic processAgtIDARatPMID:24168260|RGD:11039408
Biological ProcessGO:0008217regulation of blood pressureAGTIGIUniProtKB:P00797HumanPMID:17416596
Biological ProcessGO:0008217regulation of blood pressureAgtIMPMGI:MGI:2136636MousePMID:9557921
Biological ProcessGO:0051924regulation of calcium ion transportAgtIDARatPMID:21423294|RGD:5129170
Biological ProcessGO:1903779regulation of cardiac conductionAGTIGIUniProtKB:P00797HumanPMID:17416596
Biological ProcessGO:1901201regulation of extracellular matrix assemblyAGTIGIUniProtKB:P00797HumanPMID:17416596
Biological ProcessGO:0010468regulation of gene expressionAgtIDAMousePMID:16585392
Biological ProcessGO:0002027regulation of heart rateAgtIDARatPMID:11897768|RGD:70484
Biological ProcessGO:0050727regulation of inflammatory responseAgtIGIMGI:MGI:98259MousePMID:19404405
Biological ProcessGO:0050727regulation of inflammatory responseAgtIDAMousePMID:19404405
Biological ProcessGO:0048169regulation of long-term neuronal synaptic plasticityAgtIMPRatPMID:11282364|RGD:1582105
Biological ProcessGO:0014061regulation of norepinephrine secretionAgtIMPRatPMID:11100981|RGD:1582152
Biological ProcessGO:0002019regulation of renal output by angiotensinAgtIMPMGI:MGI:2136636MousePMID:9507198
Biological ProcessGO:0002019regulation of renal output by angiotensinAgtIMPMousePMID:11606482
Biological ProcessGO:0002019regulation of renal output by angiotensinAgtIMPMGI:MGI:2136636MousePMID:9852267
Biological ProcessGO:0035813regulation of renal sodium excretionAgtIDARatPMID:11390024|RGD:1582107
Biological ProcessGO:0001991regulation of systemic arterial blood pressure by circulatory renin-angiotensinAgtIMPMGI:MGI:2136636MousePMID:7989296
Biological ProcessGO:0001991regulation of systemic arterial blood pressure by circulatory renin-angiotensinAgtIMPMGI:MGI:2136636MousePMID:9852267
Biological ProcessGO:0001991regulation of systemic arterial blood pressure by circulatory renin-angiotensinAgtIMPMGI:MGI:2183545MousePMID:9466969
Biological ProcessGO:0001991regulation of systemic arterial blood pressure by circulatory renin-angiotensinAgtIMPMGI:MGI:1857121MousePMID:12574102
Biological ProcessGO:0001991regulation of systemic arterial blood pressure by circulatory renin-angiotensinAgtIMPMGI:MGI:2136636MousePMID:9507198
Biological ProcessGO:0001991regulation of systemic arterial blood pressure by circulatory renin-angiotensinAgtIMPMGI:MGI:2136636MousePMID:10076178
Biological ProcessGO:0001991regulation of systemic arterial blood pressure by circulatory renin-angiotensinAgtIMPMGI:MGI:2136636MousePMID:11606482
Biological ProcessGO:0051969regulation of transmission of nerve impulseAgtIDARatPMID:22198171|RGD:8549468
Biological ProcessGO:0001999renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressureAgtIMPMousePMID:11606482
Biological ProcessGO:0003014renal system processAGTIDAHumanPMID:21183621
Biological ProcessGO:0002018renin-angiotensin regulation of aldosterone productionAgtIMPMGI:MGI:2136636MousePMID:9852267
Biological ProcessGO:0002018renin-angiotensin regulation of aldosterone productionAgtIMPMGI:MGI:2136636MousePMID:10076178
Biological ProcessGO:0002018renin-angiotensin regulation of aldosterone productionAgtIDARatPMID:21318332|RGD:5129178
Biological ProcessGO:0009409response to coldAgtIMPMGI:MGI:1857121MousePMID:12574102
Biological ProcessGO:0032355response to estradiolAgtIEPRatPMID:18388195|RGD:13432362
Biological ProcessGO:0014873response to muscle activity involved in regulation of muscle adaptationAgtIMPRatPMID:8252633|RGD:8553951
Biological ProcessGO:0009651response to salt stressAgtIMPMGI:MGI:2136636MousePMID:9557921
Biological ProcessGO:0051145smooth muscle cell differentiationAgtIMPMGI:MGI:2183545MousePMID:9788961
Biological ProcessGO:0051145smooth muscle cell differentiationAgtIDAMousePMID:9788961
Biological ProcessGO:0048659smooth muscle cell proliferationAgtIMPMGI:MGI:1857121MousePMID:10318840
Biological ProcessGO:0048659smooth muscle cell proliferationAgtIMPMGI:MGI:2183545MousePMID:8675666
Biological ProcessGO:0048659smooth muscle cell proliferationAgtIMPMGI:MGI:2183545MousePMID:9788961
Biological ProcessGO:0048659smooth muscle cell proliferationAgtIDAMousePMID:9788961
Biological ProcessGO:0048659smooth muscle cell proliferationAgtIDARatPMID:21292788|RGD:5129183
Biological ProcessGO:0051403stress-activated MAPK cascadeAgtIDARatPMID:21367774|RGD:5129174
Biological ProcessGO:0070471uterine smooth muscle contractionAgtIDARatPMID:21401609|RGD:5129172
Biological ProcessGO:1990874vascular associated smooth muscle cell proliferationAgtIMPMGI:MGI:2183545MousePMID:8675666
Biological ProcessGO:0042310vasoconstrictionAgtIDARatPMID:20955746|RGD:5129197
Biological ProcessGO:0042311vasodilationAgtIDARatPMID:21056585|RGD:5129196
Biological ProcessGO:0042311vasodilationAgtIDARatPMID:23718715|RGD:8549478
Biological ProcessGO:0030103vasopressin secretionAgtIMPMGI:MGI:2136636MousePMID:9557921

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory