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Agt
Gene Detail
Symbol

Name
ID
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
MGI:87963
Synonyms
angiotensin precursor, Aogen, Serpina8
Feature Type
protein coding gene
Genetic Map
Chromosome 8
72.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr8:124556587-124569707 bp, - strand
From NCBI annotation of GRCm38

  13121 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:14  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: serpin
Gene Tree: Agt

Human
homologs
Human Homolog AGT, angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
NCBI Gene ID 183
neXtProt AC  NX_P01019
Human Synonyms  ANHU, SERPINA8
Human Chr (Location)  1q42.2; chr1:230702523-230714590 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human AGT
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutation of this gene results in small body size and lower body fat, decreased blood pressure and hypotension, kidney abnormalities, polydipsia and polyuria.
 
Phenotype Images(1)
Interactions
Agt interacts with 48 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (13 records)
Data Summary: Results (111)    Tissues (63)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 99
Northern blot 10
RT-PCR 2
cDNA source data(143)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(158) Genomic(10) cDNA(145) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031980 (Evidence)
Entrez Gene11606 (Evidence)
UniGene301626
DFCITC1576097
DoTSDT.531843
NIA Mouse Gene IndexU030392
Consensus CDS ProjectCCDS40513.1
International Mouse Knockout Project StatusAgt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11606 NCBI Gene Model | MGI Sequence Detail 13121 C57BL/6J ±  kb
transcript NM_007428 RefSeq | MGI Sequence Detail 1856 C57BL/6 
polypeptide NP_031454 RefSeq | MGI Sequence Detail 482 C57BL/6 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(7) : SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000227 Angiotensinogen
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000003847 angiotensinogen
References
(Earliest) J:20305 Abel K, et al., Mapping and expression analyses of murine angiotensinogen genes. Mouse News Lett. 1986;74:108-109
(Latest) J:213153 Harms MJ, et al., Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab. 2014 Apr 1;19(4):593-604
All references(151)
Other
accession IDs
MGD-MRK-1192, MGI:2142488

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory