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Agt
Gene Detail
Symbol

Name
ID
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
MGI:87963
Synonyms
angiotensin precursor, Aogen, Serpina8
Feature Type
protein coding gene
Genetic Map
Chromosome 8
72.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr8:124556587-124569707 bp, - strand
From NCBI annotation of GRCm38

  13121 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:14  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AGT
Protein SuperFamily: serpin
Gene Tree: Agt

Human
homologs
AGT, angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 183
neXtProt AC: NX_P01019

Human Synonyms: ANHU, SERPINA8

Human Chr (Location): 1q42.2; chr1:230702523-230714590 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human AGT

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(11) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutation of this gene results in small body size and lower body fat, decreased blood pressure and hypotension, kidney abnormalities, polydipsia and polyuria.
 
Phenotype Images(1)
Interactions
Agt interacts with 48 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (14 records)
Data Summary: Results (111)    Tissues (63)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 99
Northern blot 10
RT-PCR 2
cDNA source data(143)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA AGT ; Xenbase agt ; ZFIN agt    NEW 
Molecular
reagents
All nucleic(158) Genomic(10) cDNA(145) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000031980 (Evidence)
Entrez Gene 11606 (Evidence)
UniGene 301626
DFCI TC1576097
DoTS DT.531843
NIA Mouse Gene Index U030392
Consensus CDS Project CCDS40513.1
International Mouse Phenotyping Consortium Status Agt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11606 NCBI Gene Model | MGI Sequence Detail 13121 C57BL/6J ±  kb
transcript NM_007428 RefSeq | MGI Sequence Detail 1856 C57BL/6 
polypeptide NP_031454 RefSeq | MGI Sequence Detail 482 C57BL/6 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(7) : SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000227 Angiotensinogen
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000003847 angiotensinogen
References
(Earliest) J:20305 Abel K, et al., Mapping and expression analyses of murine angiotensinogen genes. Mouse News Lett. 1986;74:108-109
(Latest) J:218046 Cuffe JS, et al., The effects of gestational age and maternal hypoxia on the placental renin angiotensin system in the mouse. Placenta. 2014 Nov;35(11):953-61
All references(151)
Other
accession IDs
MGD-MRK-1192, MGI:2142488

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory