Agt
Gene Detail

Symbol Name ID

Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) MGI:87963

Synonyms

angiotensin precursor, Aogen, Serpina8

Feature Type

protein coding gene

Genetic Map

Chromosome 8

72.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)

Sequence Map

Chr8:124556587-124569707 bp, - strand From NCBI annotation of GRCm38   13121 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:14  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serpin
Gene Tree: Agt

Human homologs

Human Homolog		AGT, angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
NCBI Gene ID		183
neXtProt AC		NX_P01019
Human Synonyms		ANHU, SERPINA8
Human Chr (Location)		1q42.2; chr1:230838269-230850336 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human AGT

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homozygous null mutation of this gene results in small body size and lower body fat, decreased blood pressure and hypotension, kidney abnormalities, polydipsia and polyuria.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (107 annotations)

Process	activation of NF-kappaB-inducing kinase activity, activation of phospholipase C activity, ...
Component	cytoplasmic part, extracellular space
Function	acetyltransferase activator activity, angiotensin receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (111)    Tissues (62)    Images (42)
Theiler Stages: 17, 19, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	99
Northern blot	10
RT-PCR	2

cDNA source data(140)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(155) Genomic(10) cDNA(142) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000031980 (Evidence)
Entrez Gene	11606 (Evidence)
UniGene	301626
DFCI	TC1576097
DoTS	DT.531843
NIA Mouse Gene Index	U030392
Consensus CDS Project	CCDS40513.1
International Mouse Knockout Project Status	Agt

Sequences

Length	Strain/Species
genomic	11606	NCBI Gene Model | MGI Sequence Detail	13121	C57BL/6J
transcript	NM_007428	RefSeq | MGI Sequence Detail	1856	C57BL/6
polypeptide	NP_031454	RefSeq | MGI Sequence Detail	482	C57BL/6

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(7) : SNPs(91 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000227	Angiotensinogen
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000003847	angiotensinogen

References

(Earliest) J:20305 Abel K, et al., Mapping and expression analyses of murine angiotensinogen genes. Mouse News Lett. 1986;74:108-109
(Latest) J:190471 Murphy KT, et al., Disruption of muscle renin-angiotensin system in AT1a-/- mice enhances muscle function despite reducing muscle mass but compromises repair after injury. Am J Physiol Regul Integr Comp Physiol. 2012 Aug 1;303(3):R321-31
All references(141)

Other accession IDs

MGD-MRK-1192, MGI:2142488