About   Help   FAQ
Agt Gene Detail
Summary
  • Symbol
    Agt
  • Name
    angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
  • Synonyms
    angiotensin precursor, Aogen, Serpina8
  • Feature Type
    protein coding gene
  • IDs
    MGI:87963
    NCBI Gene: 11606
  • Gene Overview
    MyGene.info: AGT
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:124556587-124569707 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 72.81 cM
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87963
protein coding gene Chr8:124556534-124569707 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034272
protein coding gene Chr8:128245438-128260823 (-)
A/J MGP_AJ_G0034252
protein coding gene Chr8:122939198-122952182 (-)
AKR/J MGP_AKRJ_G0034179
protein coding gene Chr8:126469592-126488387 (-)
BALB/cJ MGP_BALBcJ_G0034245
protein coding gene Chr8:123124486-123138317 (-)
C3H/HeJ MGP_C3HHeJ_G0033956
protein coding gene Chr8:127120070-127136555 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034765
protein coding gene Chr8:132535664-132548855 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031706
protein coding gene Chr8:115708688-115721570 (-)
CAST/EiJ MGP_CASTEiJ_G0033283
protein coding gene Chr8:127236714-127250973 (-)
CBA/J MGP_CBAJ_G0033929
protein coding gene Chr8:137396367-137412818 (-)
DBA/2J MGP_DBA2J_G0034085
protein coding gene Chr8:122096196-122109344 (-)
FVB/NJ MGP_FVBNJ_G0034029
protein coding gene Chr8:121267798-121281960 (-)
LP/J MGP_LPJ_G0034174
protein coding gene Chr8:128401374-128414393 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034076
protein coding gene Chr8:139479234-139492297 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034784
protein coding gene Chr8:126710217-126723243 (-)
PWK/PhJ MGP_PWKPhJ_G0032985
protein coding gene Chr8:121860106-121873269 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032824
protein coding gene Chr8:125350926-125366646 (-)
WSB/EiJ MGP_WSBEiJ_G0033400
protein coding gene Chr8:127431587-127444652 (-)



Homology
more
  • Human Ortholog
    AGT, angiotensinogen
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AGT, angiotensinogen
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ANHU, hFLT1, SERPINA8
  • Links
    NCBI Gene ID: 183
    neXtProt AC: NX_P01019
    UniProt: P01019

  • Chr Location
    1q42.2; chr1:230702523-230714590 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 14
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AGT
  • Protein SuperFamily
  • Gene Tree
    Agt
Human Diseases
more
  • Diseases
    1 with human AGT associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 5 alleles in 5 genetic backgrounds
    43 phenotypes from multigenic genotypes
    1 images
    115 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutation of this gene results in small body size and lower body fat, decreased blood pressure and hypotension, kidney abnormalities, polydipsia and polyuria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11606 NCBI Gene Model | MGI Sequence Detail 13121 C57BL/6J ±  kb
    transcript NM_007428 RefSeq | MGI Sequence Detail 1856 C57BL/6  
    polypeptide P11859 UniProt | EBI | MGI Sequence Detail 477 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 159
      Genomic 10
      cDNA 146
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1192, MGI:2142488
    References
    more
    • Summaries
      All 259
      Developmental Gene Expression 19
      Gene Ontology 29
      Phenotypes 115
    • Earliest
      J:9259 Clouston WM, et al., Molecular cloning of the mouse angiotensinogen gene. Genomics. 1988 Apr;2(3):240-8
    • Latest
      J:260351 Chen Q, et al., Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis. Cell Rep. 2018 Mar 13;22(11):2860-2872

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory