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Agt
Gene Detail
 Symbol
Name
ID
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
MGI:87963
Synonyms angiotensin precursor, Aogen, Serpina8
Feature Type protein coding gene
Genetic Map
Chromosome 8
72.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr8:124556587-124569707 bp, - strand
From NCBI annotation of GRCm38

  13121 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:14  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serpin
Gene Tree: Agt

Human
homologs
Human Homolog AGT, angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
NCBI Gene ID 183
neXtProt AC  NX_P01019
Human Synonyms  ANHU, SERPINA8
Human Chr (Location)  1q42.2; chr1:230702523-230714590 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human AGT
Alleles
and
phenotypes
All alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutation of this gene results in small body size and lower body fat, decreased blood pressure and hypotension, kidney abnormalities, polydipsia and polyuria.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (112 annotations)
Process activation of NF-kappaB-inducing kinase activity, activation of phospholipase C activity, ...
Component blood microparticle, cytoplasm, ...
Function angiotensin receptor binding, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (111)    Tissues (62)    Images (42)
Theiler Stages: 17, 19, 20, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 99
Northern blot 10
RT-PCR 2
cDNA source data(143)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(158) Genomic(10) cDNA(145) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031980 (Evidence)
Entrez Gene11606 (Evidence)
UniGene301626
DFCITC1576097
DoTSDT.531843
NIA Mouse Gene IndexU030392
Consensus CDS ProjectCCDS40513.1
International Mouse Knockout Project StatusAgt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11606 NCBI Gene Model | MGI Sequence Detail 13121 C57BL/6J ±  kb
transcript NM_007428 RefSeq | MGI Sequence Detail 1856 C57BL/6 
polypeptide NP_031454 RefSeq | MGI Sequence Detail 482 C57BL/6 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms RFLP(7) : SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000227 Angiotensinogen
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000003847 angiotensinogen
References (Earliest) J:20305 Abel K, et al., Mapping and expression analyses of murine angiotensinogen genes. Mouse News Lett. 1986;74:108-109
(Latest) J:198125 Rajakumari S, et al., EBF2 determines and maintains brown adipocyte identity. Cell Metab. 2013 Apr 2;17(4):562-74
All references(147)
Other
accession IDs
MGD-MRK-1192, MGI:2142488

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory