Automated description from the Alliance of Genome Resources (Release 8.3.0)
Enables receptor ligand activity; type 1 angiotensin receptor binding activity; and type 2 angiotensin receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within several processes, including hormone secretion; positive regulation of metabolic process; and regulation of systemic arterial blood pressure by renin-angiotensin. Located in extracellular space. Is active in extracellular region. Is expressed in several structures, including alimentary system; axial skeleton; central nervous system; metanephros; and testis. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; IgA vasculitis; artery disease (multiple); cerebrovascular disease (multiple); and heart conduction disease (multiple). Orthologous to human AGT (angiotensinogen).
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