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Agt Gene Detail
Summary
  • Symbol
    Agt
  • Name
    angiotensinogen
  • Synonyms
    angiotensin precursor, Aogen, Serpina8
  • Feature Type
    protein coding gene
  • IDs
    MGI:87963
    NCBI Gene: 11606
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:125283326-125296445 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.81 cM
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • SNPs within 2kb
    498 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87963
 protein coding gene Chr8:125283273-125296445 (-)
129S1/SvImJ ENSMUSG00200041075
 protein coding gene Chr8:119535251-119548423 (-)
A/J ENSMUSG00195024871
 protein coding gene Chr8:119821410-119834458 (-)
AKR/J ENSMUSG00220037438
 protein coding gene Chr8:119998831-120019186 (-)
BALB/cJ ENSMUSG00180026015
 protein coding gene Chr8:119866291-119879339 (-)
C3H/HeJ ENSMUSG00175028835
 protein coding gene Chr8:119918267-119938620 (-)
C57BL/6NJ ENSMUSG00215030799
 protein coding gene Chr8:119515086-119528262 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031706
 protein coding gene Chr8:115708688-115721570 (-)
CAST/EiJ ENSTCUG00005030495
 protein coding gene Chr8:119273463-119286654 (-)
CBA/J ENSMUSG00210031758
 protein coding gene Chr8:119841106-119854280 (-)
DBA/2J ENSMUSG00185035139
 protein coding gene Chr8:126160026-126173196 (-)
FVB/NJ ENSMUSG00205033615
 protein coding gene Chr8:118813833-118826930 (-)
JF1/MsJ ENSUMUG00000032257
 protein coding gene Chr8:128373798-128386822 (-)
LP/J ENSMUSG00230025242
 protein coding gene Chr8:129717929-129731098 (-)
NOD/ShiLtJ ENSMUSG00190018898
 protein coding gene Chr8:119961486-119974568 (-)
NZO/HlLtJ ENSMUSG00225019337
 protein coding gene Chr8:133082697-133095745 (-)
PWK/PhJ ENSLUMG00010037378
 protein coding gene Chr8:119662871-119676061 (-)
SPRET/EiJ ENSMSPG00010001757
 protein coding gene Chr8:121850916-121863610 (-)
WSB/EiJ ENSIUOG00005028962
 protein coding gene Chr8:120634684-120647778 (-)



Homology
more
  • Human Ortholog
    AGT, angiotensinogen
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGT, angiotensinogen
  • Synonyms
    ANHU, hFLT1, SERPINA8
  • Links
    NCBI Gene ID: 183
    UniProt: P01019

  • Chr Location
    1q42.2; chr1:230690776-230745583 (-)  GRCh38
Human Diseases
more
  • Diseases
    23 with human AGT associations

Human Disease Mouse Models
      
IDs
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 4 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    84 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutation of this gene results in small body size and lower body fat, decreased blood pressure and hypotension, kidney abnormalities, polydipsia and polyuria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    154
  • GO References
    37
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    83
  • cDNA Data
    145
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11606 NCBI Gene Model | MGI Sequence Detail 13120 C57BL/6J ±  kb
    transcript NM_001416312 RefSeq | MGI Sequence Detail 1900 ZRU/MplStud  
    polypeptide P11859 UniProt | EBI | MGI Sequence Detail 477 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 162
      Genomic 10
      cDNA 147
      Primer pair 4
      Other 1
      Antibodies 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1192, MGI:2142488
    References
    more
    • Summaries
      All 285
      Developmental Gene Expression 28
      Gene Ontology 37
      Phenotypes 84
    • Earliest
      J:9259 Clouston WM, et al., Molecular cloning of the mouse angiotensinogen gene. Genomics. 1988 Apr;2(3):240-8
    • Latest
      J:377726 Jiang D, et al., Lmo3-expressing peri-isthmus progenitor cells sustain renewal and repair of the mammalian intestinal telocyte niche. Dev Cell. 2026 Jan 14;61(1):178-192.e5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory