Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Adam17

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ADAM17
- Mouse genes Adam17
- Rat genes Adam17
- Zfish genes adam17a,adam17b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adam17

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	ADAM17	IMP		Human	PMID:24990881
Molecular Function	GO:0004175	endopeptidase activity	ADAM17	IMP		Human	PMID:25049354
Molecular Function	GO:0004175	endopeptidase activity	Adam17	IDA		Mouse	MGI:MGI:6294190\|PMID:17245433
Molecular Function	GO:0005178	integrin binding	ADAM17	IPI	UniProtKB:P05556	Human	PMID:14970227
Molecular Function	GO:0005178	integrin binding	ADAM17	IPI	UniProtKB:P08648	Human	PMID:14970227
Molecular Function	GO:0005138	interleukin-6 receptor binding	ADAM17	IPI	UniProtKB:P08887	Human	PMID:16034137
Molecular Function	GO:0070573	metallodipeptidase activity	Adam17	IMP		Mouse	PMID:14993236
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAM17	IDA		Human	PMID:14625290
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAM17	IDA		Human	PMID:15691827
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAM17	IDA		Human	PMID:17010968
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAM17	IDA		Human	PMID:24226769
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAM17	IDA		Human	PMID:24337742
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAM17	IMP		Human	PMID:9034190
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAM17	IMP		Human	PMID:9034191
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAM17	IDA		Human	PMID:9774383
Molecular Function	GO:0004222	metalloendopeptidase activity	ADAM17	IDA		Human	PMID:9920899
Molecular Function	GO:0004222	metalloendopeptidase activity	Adam17	IMP		Mouse	PMID:14993236
Molecular Function	GO:1902945	metalloendopeptidase activity involved in amyloid precursor protein catabolic process	ADAM17	IDA		Human	PMID:9774383
Molecular Function	GO:0008237	metallopeptidase activity	ADAM17	IMP		Human	PMID:12535668
Molecular Function	GO:0008237	metallopeptidase activity	ADAM17	IDA		Human	PMID:12777399
Molecular Function	GO:0008237	metallopeptidase activity	Adam17	IDA		Mouse	MGI:MGI:3040545\|PMID:14761956
Molecular Function	GO:0008237	metallopeptidase activity	Adam17	IMP		Mouse	PMID:14993236
Molecular Function	GO:0008237	metallopeptidase activity	Adam17	IMP		Mouse	PMID:17169360
Molecular Function	GO:0008237	metallopeptidase activity	Adam17	IMP	MGI:MGI:1857753	Mouse	PMID:14993236
Molecular Function	GO:0008237	metallopeptidase activity	Adam17	IMP	MGI:MGI:4354847	Mouse	PMID:28751722
Molecular Function	GO:0008237	metallopeptidase activity	Adam17	IDA		Mouse	PMID:26651291
Molecular Function	GO:0008237	metallopeptidase activity	Adam17	IMP		Mouse	PMID:26651291
Molecular Function	GO:0005112	Notch binding	ADAM17	IDA		Human	PMID:24226769
Molecular Function	GO:0030165	PDZ domain binding	ADAM17	IPI	UniProtKB:P26045	Human	PMID:12207026
Molecular Function	GO:0005515	protein binding	ADAM17	IPI	UniProtKB:Q13257	Human	PMID:10527948
Molecular Function	GO:0005515	protein binding	ADAM17	IPI	UniProtKB:Q9UI95	Human	PMID:10527948
Molecular Function	GO:0005515	protein binding	ADAM17	IPI	UniProtKB:Q12959	Human	PMID:12668732
Molecular Function	GO:0005515	protein binding	ADAM17	IPI	UniProtKB:Q5HYK7-4	Human	PMID:15280379
Molecular Function	GO:0005515	protein binding	ADAM17	IPI	UniProtKB:Q5HYK7-5	Human	PMID:15280379
Molecular Function	GO:0005515	protein binding	ADAM17	IPI	UniProtKB:O43847	Human	PMID:18355445
Molecular Function	GO:0005515	protein binding	ADAM17	IPI	UniProtKB:P36897	Human	PMID:18625725
Molecular Function	GO:0005515	protein binding	ADAM17	IPI	UniProtKB:P35625	Human	PMID:18638486
Molecular Function	GO:0005515	protein binding	ADAM17	IPI	UniProtKB:Q80WQ6	Human	PMID:22246777
Molecular Function	GO:0005515	protein binding	ADAM17	IPI	UniProtKB:P05556	Human	PMID:22413019
Molecular Function	GO:0005515	protein binding	ADAM17	IPI	UniProtKB:Q9BZ67	Human	PMID:29897336
Molecular Function	GO:0005515	protein binding	ADAM17	IPI	UniProtKB:P05556	Human	PMID:30455686
Molecular Function	GO:0005515	protein binding	ADAM17	IPI	UniProtKB:P05067	Human	PMID:9774383
Molecular Function	GO:0005515	protein binding	Adam17	IPI	UniProtKB:Q80WQ6	Mouse	MGI:MGI:5302863\|PMID:22246777
Molecular Function	GO:0005515	protein binding	Adam17	IPI	UniProtKB:Q80WQ6	Mouse	MGI:MGI:5302862\|PMID:22246778
Molecular Function	GO:0005515	protein binding	Adam17	IPI	PR:Q01705	Mouse	PMID:15574878
Cellular Component	GO:0015629	actin cytoskeleton	ADAM17	IDA		Human	PMID:17010968
Cellular Component	GO:0045177	apical part of cell	Adam17	IDA		Rat	PMID:25232008\|RGD:13703036
Cellular Component	GO:0016324	apical plasma membrane	ADAM17	IDA		Human	PMID:16034137
Cellular Component	GO:0009986	cell surface	ADAM17	IDA		Human	PMID:18383040
Cellular Component	GO:0009986	cell surface	ADAM17	IDA		Human	PMID:18625725
Cellular Component	GO:0009986	cell surface	ADAM17	IDA		Human	PMID:9034190
Cellular Component	GO:0009986	cell surface	Adam17	IDA		Rat	PMID:21503882\|RGD:5686904
Cellular Component	GO:0005911	cell-cell junction	ADAM17	IDA		Human	PMID:14970227
Cellular Component	GO:0005737	cytoplasm	ADAM17	IDA		Human	PMID:25468996
Cellular Component	GO:0005737	cytoplasm	Adam17	IDA		Mouse	PMID:15739225
Cellular Component	GO:0031410	cytoplasmic vesicle	Adam17	IDA		Rat	PMID:25232008\|RGD:13703036
Cellular Component	GO:0005829	cytosol	ADAM17	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	ADAM17	IDA		Human	PMID:14970227
Cellular Component	GO:0016020	membrane	ADAM17	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Adam17	IDA		Mouse	PMID:26651291
Cellular Component	GO:0045121	membrane raft	ADAM17	IDA		Human	PMID:17010968
Cellular Component	GO:0045121	membrane raft	ADAM17	IDA		Human	PMID:17786981
Cellular Component	GO:0005886	plasma membrane	ADAM17	IDA		Human	PMID:17786981
Cellular Component	GO:0005886	plasma membrane	ADAM17	IDA		Human	PMID:24337742
Cellular Component	GO:0005886	plasma membrane	Adam17	IMP		Mouse	PMID:14993236
Cellular Component	GO:0005886	plasma membrane	Adam17	IMP		Mouse	PMID:17169360
Cellular Component	GO:0005886	plasma membrane	Adam17	IMP	MGI:MGI:1857753	Mouse	PMID:14993236
Cellular Component	GO:0005886	plasma membrane	Adam17	IMP	MGI:MGI:4354847	Mouse	PMID:28751722
Cellular Component	GO:0005886	plasma membrane	Adam17	IDA		Rat	PMID:15284022\|RGD:2317978
Cellular Component	GO:0032587	ruffle membrane	ADAM17	IDA		Human	PMID:14970227
Biological Process	GO:0042987	amyloid precursor protein catabolic process	ADAM17	IDA		Human	PMID:9774383
Biological Process	GO:0030183	B cell differentiation	Adam17	IMP		Mouse	MGI:MGI:3828349\|PMID:17371977
Biological Process	GO:0007155	cell adhesion	ADAM17	IDA		Human	PMID:14970227
Biological Process	GO:0033627	cell adhesion mediated by integrin	ADAM17	IDA		Human	PMID:14970227
Biological Process	GO:0048870	cell motility	Adam17	IMP		Mouse	MGI:MGI:3829110\|PMID:18625725
Biological Process	GO:0071403	cellular response to high density lipoprotein particle stimulus	ADAM17	IDA		Human	PMID:17786981
Biological Process	GO:0050830	defense response to Gram-positive bacterium	ADAM17	IMP		Human	PMID:16034137
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ADAM17	IDA		Human	PMID:12743035
Biological Process	GO:0002467	germinal center formation	Adam17	IMP		Mouse	MGI:MGI:3828349\|PMID:17371977
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM17	IMP		Human	PMID:12743035
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM17	IDA		Human	PMID:14625290
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM17	IDA		Human	PMID:15691827
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM17	IMP		Human	PMID:16034137
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM17	IDA		Human	PMID:17010968
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM17	IDA		Human	PMID:17786981
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM17	IMP		Human	PMID:18373975
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM17	IDA		Human	PMID:18676862
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM17	IMP		Human	PMID:21170088
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM17	IDA		Human	PMID:24337742
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM17	IMP		Human	PMID:24990881
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM17	IDA		Human	PMID:9034190
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM17	IMP		Human	PMID:9034191
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ADAM17	IDA		Human	PMID:9574564
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Adam17	IDA		Mouse	MGI:MGI:3828405\|PMID:15691827
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Adam17	IMP		Mouse	MGI:MGI:85910\|PMID:9034190
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Adam17	IDA		Mouse	MGI:MGI:6294190\|PMID:17245433
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Adam17	IDA		Mouse	PMID:26651291
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Adam17	IMP		Mouse	PMID:26651291
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Adam17	IMP		Rat	PMID:15284022\|RGD:2317978
Biological Process	GO:0043066	negative regulation of apoptotic process	Adam17	IDA		Rat	PMID:11973430\|RGD:632021
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Adam17	IMP		Mouse	MGI:MGI:6101010\|PMID:18687778
Biological Process	GO:0010977	negative regulation of neuron projection development	Adam17	IGI	MGI:MGI:2679262	Mouse	PMID:26651291
Biological Process	GO:0010977	negative regulation of neuron projection development	Adam17	IGI	MGI:MGI:2443718	Mouse	PMID:26651291
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ADAM17	IMP		Human	PMID:21170088
Biological Process	GO:0007220	Notch receptor processing	ADAM17	IDA		Human	PMID:24226769
Biological Process	GO:0043065	positive regulation of apoptotic process	Adam17	IMP		Rat	PMID:21503882\|RGD:5686904
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ADAM17	IDA		Human	PMID:24813629
Biological Process	GO:0030307	positive regulation of cell growth	ADAM17	IMP		Human	PMID:18373975
Biological Process	GO:0030335	positive regulation of cell migration	ADAM17	IMP		Human	PMID:18373975
Biological Process	GO:0030335	positive regulation of cell migration	ADAM17	IDA		Human	PMID:26617808
Biological Process	GO:0008284	positive regulation of cell population proliferation	ADAM17	IMP		Human	PMID:18373975
Biological Process	GO:0032722	positive regulation of chemokine production	ADAM17	IMP		Human	PMID:16034137
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	ADAM17	IMP		Human	PMID:18483258
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	ADAM17	IMP		Human	PMID:17655843
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	ADAM17	IDA		Human	PMID:18483258
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Adam17	IMP		Rat	PMID:23688779\|RGD:13703057
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	ADAM17	IMP		Human	PMID:18483258
Biological Process	GO:0010976	positive regulation of neuron projection development	Adam17	IMP		Rat	PMID:21645559\|RGD:13703101
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ADAM17	IMP		Human	PMID:18625725
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	ADAM17	IMP		Human	PMID:18373975
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	Adam17	IMP		Mouse	MGI:MGI:3829110\|PMID:18625725
Biological Process	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	ADAM17	IMP		Human	PMID:24813629
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	ADAM17	IDA		Human	PMID:24813629
Biological Process	GO:0002532	production of molecular mediator involved in inflammatory response	Adam17	IDA		Mouse	MGI:MGI:5619466\|PMID:20610799
Biological Process	GO:0016485	protein processing	ADAM17	IDA		Human	PMID:9774383
Biological Process	GO:0006508	proteolysis	ADAM17	IDA		Human	PMID:24227843
Biological Process	GO:0035624	receptor transactivation	ADAM17	IMP		Human	PMID:17655843
Biological Process	GO:0035624	receptor transactivation	Adam17	IMP		Rat	PMID:25232008\|RGD:13703036
Biological Process	GO:0048679	regulation of axon regeneration	Adam17	IGI	MGI:MGI:2443718	Mouse	PMID:26651291
Biological Process	GO:0033025	regulation of mast cell apoptotic process	Adam17	IMP		Mouse	MGI:MGI:3828408\|PMID:14625290
Biological Process	GO:2001222	regulation of neuron migration	Adam17	IGI	MGI:MGI:1097159	Mouse	PMID:26651291
Biological Process	GO:2001222	regulation of neuron migration	Adam17	IGI	MGI:MGI:2443718	Mouse	PMID:26651291
Biological Process	GO:0097327	response to antineoplastic agent	Adam17	IEP		Rat	PMID:21503882\|RGD:5686904
Biological Process	GO:1990910	response to hypobaric hypoxia	Adam17	IEP		Rat	PMID:22230263\|RGD:13703065
Biological Process	GO:0001666	response to hypoxia	ADAM17	IDA		Human	PMID:18276953
Biological Process	GO:0032496	response to lipopolysaccharide	ADAM17	IDA		Human	PMID:18383040
Biological Process	GO:0009410	response to xenobiotic stimulus	Adam17	IMP		Mouse	MGI:MGI:3828403\|PMID:16179345
Biological Process	GO:0140448	signaling receptor ligand precursor processing	Adam17	IMP		Mouse	PMID:14993236
Biological Process	GO:0140448	signaling receptor ligand precursor processing	Adam17	IMP		Mouse	PMID:17169360
Biological Process	GO:0140448	signaling receptor ligand precursor processing	Adam17	IMP	MGI:MGI:1857753	Mouse	PMID:14993236
Biological Process	GO:0140448	signaling receptor ligand precursor processing	Adam17	IMP	MGI:MGI:4354847	Mouse	PMID:28751722
Biological Process	GO:0007283	spermatogenesis	Adam17	IEP		Rat	PMID:25053185\|RGD:13702088
Biological Process	GO:0048536	spleen development	Adam17	IMP		Mouse	MGI:MGI:3828349\|PMID:17371977
Biological Process	GO:0033077	T cell differentiation in thymus	Adam17	IMP		Mouse	MGI:MGI:3828349\|PMID:17371977
Biological Process	GO:0035313	wound healing, spreading of epidermal cells	ADAM17	IEP		Human	PMID:14970227

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.