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Gene Ontology Browser
Term Detail
GO term:epidermal growth factor receptor signaling pathway
Synonym: EGF receptor signaling pathway
Synonym: EGF receptor signalling pathway
Synonym: EGFR signaling pathway
Synonym: epidermal growth factor receptor signalling pathway
Synonym: ERBB1 signaling pathway
Synonym: receptor tyrosine-protein kinase erbB-1 signaling pathway
GO id:GO:0007173
Definition:A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
Number of paths to term: 9

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aenzyme linked receptor protein signaling pathway
                                                                is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                        is-aERBB signaling pathway
                                                                                is-aepidermal growth factor receptor signaling pathway [GO:0007173] (71 genes, 95 annotations)
                                                                                        is-aepidermal growth factor receptor signaling pathway involved in lung development
                                                                                        is-aepidermal growth factor receptor signaling pathway via MAPK cascade
                                                                                        is-aepidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity +
                                                                                        is-aepidermal growth factor signaling pathway involved in forebrain neuron fate commitment
                                                                                        is-aERBB2-EGFR signaling pathway
                                                                                        is-aERBB4-EGFR signaling pathway
                                                                                        is-agurken signaling pathway
                                                                                        negatively-regulatesnegative regulation of epidermal growth factor receptor signaling pathway +
                                                                                        positively-regulatespositive regulation of epidermal growth factor receptor signaling pathway +
                                                                                        regulatesregulation of epidermal growth factor receptor signaling pathway +
                                                                                is-aERBB2 signaling pathway +
                                                                                is-aERBB3 signaling pathway +
                                                                                is-aERBB4 signaling pathway +
                                                                                negatively-regulatesnegative regulation of ERBB signaling pathway +
                                                                                positively-regulatespositive regulation of ERBB signaling pathway +
                                                                                regulatesregulation of ERBB signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                is-aERBB signaling pathway
                                                                        is-aepidermal growth factor receptor signaling pathway [GO:0007173] (71 genes, 95 annotations)
                                                                                is-aepidermal growth factor receptor signaling pathway involved in lung development
                                                                                is-aepidermal growth factor receptor signaling pathway via MAPK cascade
                                                                                is-aepidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity +
                                                                                is-aepidermal growth factor signaling pathway involved in forebrain neuron fate commitment
                                                                                is-aERBB2-EGFR signaling pathway
                                                                                is-aERBB4-EGFR signaling pathway
                                                                                is-agurken signaling pathway
                                                                                negatively-regulatesnegative regulation of epidermal growth factor receptor signaling pathway +
                                                                                positively-regulatespositive regulation of epidermal growth factor receptor signaling pathway +
                                                                                regulatesregulation of epidermal growth factor receptor signaling pathway +
                                                                        is-aERBB2 signaling pathway +
                                                                        is-aERBB3 signaling pathway +
                                                                        is-aERBB4 signaling pathway +
                                                                        negatively-regulatesnegative regulation of ERBB signaling pathway +
                                                                        positively-regulatespositive regulation of ERBB signaling pathway +
                                                                        regulatesregulation of ERBB signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                is-aERBB signaling pathway
                                                                        is-aepidermal growth factor receptor signaling pathway [GO:0007173] (71 genes, 95 annotations)
                                                                                is-aepidermal growth factor receptor signaling pathway involved in lung development
                                                                                is-aepidermal growth factor receptor signaling pathway via MAPK cascade
                                                                                is-aepidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity +
                                                                                is-aepidermal growth factor signaling pathway involved in forebrain neuron fate commitment
                                                                                is-aERBB2-EGFR signaling pathway
                                                                                is-aERBB4-EGFR signaling pathway
                                                                                is-agurken signaling pathway
                                                                                negatively-regulatesnegative regulation of epidermal growth factor receptor signaling pathway +
                                                                                positively-regulatespositive regulation of epidermal growth factor receptor signaling pathway +
                                                                                regulatesregulation of epidermal growth factor receptor signaling pathway +
                                                                        is-aERBB2 signaling pathway +
                                                                        is-aERBB3 signaling pathway +
                                                                        is-aERBB4 signaling pathway +
                                                                        negatively-regulatesnegative regulation of ERBB signaling pathway +
                                                                        positively-regulatespositive regulation of ERBB signaling pathway +
                                                                        regulatesregulation of ERBB signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aenzyme linked receptor protein signaling pathway
                                                                is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                        is-aERBB signaling pathway
                                                                                is-aepidermal growth factor receptor signaling pathway [GO:0007173] (71 genes, 95 annotations)
                                                                                        is-aepidermal growth factor receptor signaling pathway involved in lung development
                                                                                        is-aepidermal growth factor receptor signaling pathway via MAPK cascade
                                                                                        is-aepidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity +
                                                                                        is-aepidermal growth factor signaling pathway involved in forebrain neuron fate commitment
                                                                                        is-aERBB2-EGFR signaling pathway
                                                                                        is-aERBB4-EGFR signaling pathway
                                                                                        is-agurken signaling pathway
                                                                                        negatively-regulatesnegative regulation of epidermal growth factor receptor signaling pathway +
                                                                                        positively-regulatespositive regulation of epidermal growth factor receptor signaling pathway +
                                                                                        regulatesregulation of epidermal growth factor receptor signaling pathway +
                                                                                is-aERBB2 signaling pathway +
                                                                                is-aERBB3 signaling pathway +
                                                                                is-aERBB4 signaling pathway +
                                                                                negatively-regulatesnegative regulation of ERBB signaling pathway +
                                                                                positively-regulatespositive regulation of ERBB signaling pathway +
                                                                                regulatesregulation of ERBB signaling pathway +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                is-aERBB signaling pathway
                                                                        is-aepidermal growth factor receptor signaling pathway [GO:0007173] (71 genes, 95 annotations)
                                                                                is-aepidermal growth factor receptor signaling pathway involved in lung development
                                                                                is-aepidermal growth factor receptor signaling pathway via MAPK cascade
                                                                                is-aepidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity +
                                                                                is-aepidermal growth factor signaling pathway involved in forebrain neuron fate commitment
                                                                                is-aERBB2-EGFR signaling pathway
                                                                                is-aERBB4-EGFR signaling pathway
                                                                                is-agurken signaling pathway
                                                                                negatively-regulatesnegative regulation of epidermal growth factor receptor signaling pathway +
                                                                                positively-regulatespositive regulation of epidermal growth factor receptor signaling pathway +
                                                                                regulatesregulation of epidermal growth factor receptor signaling pathway +
                                                                        is-aERBB2 signaling pathway +
                                                                        is-aERBB3 signaling pathway +
                                                                        is-aERBB4 signaling pathway +
                                                                        negatively-regulatesnegative regulation of ERBB signaling pathway +
                                                                        positively-regulatespositive regulation of ERBB signaling pathway +
                                                                        regulatesregulation of ERBB signaling pathway +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                is-aERBB signaling pathway
                                                                        is-aepidermal growth factor receptor signaling pathway [GO:0007173] (71 genes, 95 annotations)
                                                                                is-aepidermal growth factor receptor signaling pathway involved in lung development
                                                                                is-aepidermal growth factor receptor signaling pathway via MAPK cascade
                                                                                is-aepidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity +
                                                                                is-aepidermal growth factor signaling pathway involved in forebrain neuron fate commitment
                                                                                is-aERBB2-EGFR signaling pathway
                                                                                is-aERBB4-EGFR signaling pathway
                                                                                is-agurken signaling pathway
                                                                                negatively-regulatesnegative regulation of epidermal growth factor receptor signaling pathway +
                                                                                positively-regulatespositive regulation of epidermal growth factor receptor signaling pathway +
                                                                                regulatesregulation of epidermal growth factor receptor signaling pathway +
                                                                        is-aERBB2 signaling pathway +
                                                                        is-aERBB3 signaling pathway +
                                                                        is-aERBB4 signaling pathway +
                                                                        negatively-regulatesnegative regulation of ERBB signaling pathway +
                                                                        positively-regulatespositive regulation of ERBB signaling pathway +
                                                                        regulatesregulation of ERBB signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                is-aERBB signaling pathway
                                                                        is-aepidermal growth factor receptor signaling pathway [GO:0007173] (71 genes, 95 annotations)
                                                                                is-aepidermal growth factor receptor signaling pathway involved in lung development
                                                                                is-aepidermal growth factor receptor signaling pathway via MAPK cascade
                                                                                is-aepidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity +
                                                                                is-aepidermal growth factor signaling pathway involved in forebrain neuron fate commitment
                                                                                is-aERBB2-EGFR signaling pathway
                                                                                is-aERBB4-EGFR signaling pathway
                                                                                is-agurken signaling pathway
                                                                                negatively-regulatesnegative regulation of epidermal growth factor receptor signaling pathway +
                                                                                positively-regulatespositive regulation of epidermal growth factor receptor signaling pathway +
                                                                                regulatesregulation of epidermal growth factor receptor signaling pathway +
                                                                        is-aERBB2 signaling pathway +
                                                                        is-aERBB3 signaling pathway +
                                                                        is-aERBB4 signaling pathway +
                                                                        negatively-regulatesnegative regulation of ERBB signaling pathway +
                                                                        positively-regulatespositive regulation of ERBB signaling pathway +
                                                                        regulatesregulation of ERBB signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aenzyme linked receptor protein signaling pathway
                                                        is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                is-aERBB signaling pathway
                                                                        is-aepidermal growth factor receptor signaling pathway [GO:0007173] (71 genes, 95 annotations)
                                                                                is-aepidermal growth factor receptor signaling pathway involved in lung development
                                                                                is-aepidermal growth factor receptor signaling pathway via MAPK cascade
                                                                                is-aepidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity +
                                                                                is-aepidermal growth factor signaling pathway involved in forebrain neuron fate commitment
                                                                                is-aERBB2-EGFR signaling pathway
                                                                                is-aERBB4-EGFR signaling pathway
                                                                                is-agurken signaling pathway
                                                                                negatively-regulatesnegative regulation of epidermal growth factor receptor signaling pathway +
                                                                                positively-regulatespositive regulation of epidermal growth factor receptor signaling pathway +
                                                                                regulatesregulation of epidermal growth factor receptor signaling pathway +
                                                                        is-aERBB2 signaling pathway +
                                                                        is-aERBB3 signaling pathway +
                                                                        is-aERBB4 signaling pathway +
                                                                        negatively-regulatesnegative regulation of ERBB signaling pathway +
                                                                        positively-regulatespositive regulation of ERBB signaling pathway +
                                                                        regulatesregulation of ERBB signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aenzyme linked receptor protein signaling pathway
                                                                is-atransmembrane receptor protein tyrosine kinase signaling pathway
                                                                        is-aERBB signaling pathway
                                                                                is-aepidermal growth factor receptor signaling pathway [GO:0007173] (71 genes, 95 annotations)
                                                                                        is-aepidermal growth factor receptor signaling pathway involved in lung development
                                                                                        is-aepidermal growth factor receptor signaling pathway via MAPK cascade
                                                                                        is-aepidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity +
                                                                                        is-aepidermal growth factor signaling pathway involved in forebrain neuron fate commitment
                                                                                        is-aERBB2-EGFR signaling pathway
                                                                                        is-aERBB4-EGFR signaling pathway
                                                                                        is-agurken signaling pathway
                                                                                        negatively-regulatesnegative regulation of epidermal growth factor receptor signaling pathway +
                                                                                        positively-regulatespositive regulation of epidermal growth factor receptor signaling pathway +
                                                                                        regulatesregulation of epidermal growth factor receptor signaling pathway +
                                                                                is-aERBB2 signaling pathway +
                                                                                is-aERBB3 signaling pathway +
                                                                                is-aERBB4 signaling pathway +
                                                                                negatively-regulatesnegative regulation of ERBB signaling pathway +
                                                                                positively-regulatespositive regulation of ERBB signaling pathway +
                                                                                regulatesregulation of ERBB signaling pathway +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory