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Term Detail
GO term:metallopeptidase activity
Synonym: metalloprotease activity
Synonym: metalloproteinase activity
GO id:GO:0008237
Definition:Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship

                is-acatalytic activity
                        is-ahydrolase activity
                                is-apeptidase activity
                                        is-apeptidase activity, acting on L-amino acid peptides
                                                is-aaspartic-type peptidase activity +
                                                is-aATP-dependent peptidase activity
                                                is-acysteine-type peptidase activity +
                                                is-aendopeptidase activity +
                                                is-aexopeptidase activity +
                                                is-aglutamic-type peptidase activity +
                                                is-ametallopeptidase activity [GO:0008237] (176 genes, 340 annotations)
                                                        is-ametalloendopeptidase activity +
                                                        is-ametalloexopeptidase activity +
                                                is-aserine-type peptidase activity +
                                                is-athreonine-type peptidase activity +

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory