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Adam17 Gene Detail
Summary
  • Symbol
    Adam17
  • Name
    a disintegrin and metallopeptidase domain 17
  • Synonyms
    CD156b, Tace
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096335
    NCBI Gene: 11491
  • Gene Overview
    MyGene.info: ADAM17
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:21323509-21373632 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 8.30 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    755 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096335
protein coding gene Chr12:21323509-21373632 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019625
protein coding gene Chr12:18877556-18928866 (-)
A/J MGP_AJ_G0019592
protein coding gene Chr12:18168073-18219931 (-)
AKR/J MGP_AKRJ_G0019563
protein coding gene Chr12:19005584-19059581 (-)
BALB/cJ MGP_BALBcJ_G0019569
protein coding gene Chr12:18544450-18594937 (-)
C3H/HeJ MGP_C3HHeJ_G0019373
protein coding gene Chr12:18898739-18950068 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020017
protein coding gene Chr12:19578093-19634066 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017642
protein coding gene Chr12:17768616-17818824 (-)
CAST/EiJ MGP_CASTEiJ_G0018928
protein coding gene Chr12:16168967-16222116 (-)
CBA/J MGP_CBAJ_G0019345
protein coding gene Chr12:20315005-20374231 (-)
DBA/2J MGP_DBA2J_G0019458
protein coding gene Chr12:18200643-18250745 (-)
FVB/NJ MGP_FVBNJ_G0019449
protein coding gene Chr12:18100913-18150424 (-)
LP/J MGP_LPJ_G0019528
protein coding gene Chr12:18978364-19031972 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019484
protein coding gene Chr12:20133877-20188668 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020056
protein coding gene Chr12:18580108-18633901 (-)
PWK/PhJ MGP_PWKPhJ_G0018694
protein coding gene Chr12:15475304-15526987 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018483
protein coding gene Chr12:15871179-15925700 (-)
WSB/EiJ MGP_WSBEiJ_G0018979
protein coding gene Chr12:18765511-18817297 (-)



Homology
more
  • Human Ortholog
    ADAM17, ADAM metallopeptidase domain 17
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ADAM17, ADAM metallopeptidase domain 17
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE
  • Links
    NCBI Gene ID: 6868
    neXtProt AC: NX_P78536
    UniProt: P78536

  • Chr Location
    2p25.1; chr2:9488486-9555820 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2395
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ADAM17
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    168 phenotypes from 15 alleles in 25 genetic backgrounds
    12 phenotypes from multigenic genotypes
    6 images
    104 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Most mice homozygous for targeted mutations that inactivate the gene die perinatally with stunted vibrissae and open eyelids. Survivors display various degrees of eye degeneration, perturbed hair coats, curly vibrissae, and irregular pigmentation patterns. Histological analysis of fetuses reveal defects in epithelial cell maturation and organization in multiple organs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11491 NCBI Gene Model | MGI Sequence Detail 50124 C57BL/6J ±  kb
    transcript NM_001277266 RefSeq | MGI Sequence Detail 4508 C57BL/6  
    polypeptide Q9Z0F8 UniProt | EBI | MGI Sequence Detail 827 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 2
      cDNA 23
      Primer pair 2

      Microarray probesets 6
    References
    more
    • Summaries
      All 222
      Developmental Gene Expression 20
      Gene Ontology 18
      Phenotypes 104
    • Earliest
      J:38526 Moss ML, et al., Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha [published erratum appears in Nature 1997 Apr 17;386(6626):738]. Nature. 1997 Feb 20;385(6618):733-6
    • Latest
      J:265279 Tang J, et al., Neutrophil and macrophage cell surface CSF-1 shed by ADAM17 drives mouse macrophage proliferation in acute and chronic inflammation. Mol Cell Biol. 2018 Jun 11;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory