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Adam17 Gene Detail
Summary
  • Symbol
    Adam17
  • Name
    a disintegrin and metallopeptidase domain 17
  • Synonyms
    CD156b, Tace
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096335
    NCBI Gene: 11491
  • Gene Overview
    MyGene.info: ADAM17
Location & Maps
more
  • Sequence Map
    Chr12:21323509-21373632 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      50124 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 8.30 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    ADAM17, ADAM metallopeptidase domain 17
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ADAM17, ADAM metallopeptidase domain 17
    Orthology source: HomoloGene
  • Synonyms
    ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE
  • Links
    NCBI Gene ID: 6868
    neXtProt AC: NX_P78536

  • Chr Location
    2p25; chr2:9489263-9555788 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2395
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: ADAM17
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ADAM17 associations

Human Disease Mouse Models
       Inflammatory Skin and Bowel Disease, Neonatal, 1; NISBD1   OMIM: 614328
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    159 phenotypes from 15 alleles in 22 genetic backgrounds
    12 phenotypes from multigenic genotypes
    4 images
    88 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    28
  • Chemically induced (ENU)
    1
  • Gene trapped
    10
  • Spontaneous
    1
  • Targeted
    16
  • Incidental Mutations
Most mice homozygous for targeted mutations that inactivate the gene die perinatally with stunted vibrissae and open eyelids. Survivors display various degrees of eye degeneration, perturbed hair coats, curly vibrissae, and irregular pigmentation patterns. Histological analysis of fetuses reveal defects in epithelial cell maturation and organization in multiple organs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021042 VEGA Gene Model | MGI Sequence Detail 50124 C57BL/6J ±  kb
transcript OTTMUST00000049767 VEGA | MGI Sequence Detail 4469 Not Applicable  
polypeptide OTTMUSP00000023112 VEGA | MGI Sequence Detail 846 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    755 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 26
    Genomic 2
    cDNA 22
    Primer pair 2

    Microarray probesets 6
References
more
  • Summaries
    All 176
    Developmental Gene Expression 18
    Gene Ontology 14
    Phenotypes 88
  • Earliest
    J:38526 Moss ML, et al., Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha [published erratum appears in Nature 1997 Apr 17;386(6626):738]. Nature. 1997 Feb 20;385(6618):733-6
  • Latest
    J:230318 Becker AM, et al., ADAM17 limits the expression of CSF1R on murine hematopoietic progenitors. Exp Hematol. 2015 Jan;43(1):44-52.e1-3

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory