Adam17
Gene Detail

Symbol Name ID

Adam17 a disintegrin and metallopeptidase domain 17 MGI:1096335

Synonyms

CD156b, Tace

Feature Type

protein coding gene

Genetic Map

Chromosome 12

8.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr12:21323509-21373632 bp, - strand From VEGA annotation of GRCm38   50124 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2395  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Adam17

Human homologs

Human Homolog		ADAM17, ADAM metallopeptidase domain 17
NCBI Gene ID		6868
neXtProt AC		NX_P78536
Human Synonyms		ADAM18, CD156B, CSVP, NISBD, TACE
Human Chr (Location)		2p25; chr2:9629392-9695917 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ADAM17

Alleles and phenotypes

All alleles(26) : Targeted(14) Gene trapped(10) Spontaneous(1) Chemically induced(1)
 

Most mice homozygous for targeted mutations that inactivate the gene die perinatally with stunted vibrissae and open eyelids. Survivors display various degrees of eye degeneration, perturbed hair coats, curly vibrissae, and irregular pigmentation patterns. Histological analysis of fetuses reveal defects in epithelial cell maturation and organization in multiple organs.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (63 annotations)

Process	B cell differentiation, cell adhesion, ...
Component	actin cytoskeleton, apical plasma membrane, ...
Function	hydrolase activity, integrin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (21)    Tissues (12)    Images (19)
Theiler Stages: 15, 16, 20, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	19
RNA in situ	1
RT-PCR	1

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(2) cDNA(20) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000021042 (Evidence)
Ensembl Gene Model	ENSMUSG00000052593 (Evidence)
Entrez Gene	11491 (Evidence)
NIA Mouse Gene Index	U113451
EC	3.4.24.86
Consensus CDS Project	CCDS25836.1
International Mouse Knockout Project Status	Adam17

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021042	VEGA Gene Model | MGI Sequence Detail	50124	C57BL/6J
transcript	OTTMUST00000049767	VEGA | MGI Sequence Detail	4469	Not Applicable
polypeptide	OTTMUSP00000023112	VEGA | MGI Sequence Detail	846	Not Applicable

All sequences(90) RefSeq(5) UniProt(12)

Polymorphisms

RFLP(2) : SNPs(403 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001762	Blood coagulation inhibitor, Disintegrin
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR001590	Peptidase M12B, ADAM/reprolysin
InterPro	IPR002870	Peptidase M12B, propeptide
Protein Ontology	PR:000001279	ADAM 17 endopeptidase

References

(Earliest) J:38526 Moss ML, et al., Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha [published erratum appears in Nature 1997 Apr 17;386(6626):738]. Nature. 1997 Feb 20;385(6618):733-6
(Latest) J:195804 Saito K, et al., Conditional inactivation of TNFalpha-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones. PLoS One. 2013;8(1):e54853
All references(138)