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Symbol
Name
ID

Adam17
a disintegrin and metallopeptidase domain 17
MGI:1096335

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Type II diabetes mellitus	Insulin resistance
Disease(s) Associated with ADAM17	Type II diabetes mellitus	Insulin resistance
type 2 diabetes mellitus

Mouse Phenotypes		nuchal edema	abnormal platelet physiology	abnormal circulating chemokine level	increased circulating interleukin-17 level	decreased circulating tumor necrosis factor level	cyanosis	impaired skin barrier function	abnormal chemokine level	decreased transforming growth factor beta level	decreased physiological sensitivity to xenobiotic
Availability	Mouse Genotype	nuchal edema	abnormal platelet physiology	abnormal circulating chemokine level	increased circulating interleukin-17 level	decreased circulating tumor necrosis factor level	cyanosis	impaired skin barrier function	abnormal chemokine level	decreased transforming growth factor beta level	decreased physiological sensitivity to xenobiotic
	Adam17^m1Btlr/Adam17^m1Btlr
	Adam17^tm1.1Srj/Adam17^tm1.1Srj
	Adam17^tm1Imx/Adam17^tm1Imx
	Adam17^tm1Rain/Adam17^tm1Rain
	Adam17^tm1.2Bbl/Adam17^tm1.2Bbl Sox9^tm3(cre)Crm/Sox9⁺ (conditional)
	Adam17^tm1Bbl/Adam17^tm1Bbl Lyz2^tm1(cre)Ifo/0 (conditional)
	Adam17^tm1Bbl/Adam17^tm1Bbl Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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