Gene Ontology Classifications

Symbol
Name
ID

Adam17
a disintegrin and metallopeptidase domain 17
MGI:1096335

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Automated description from the Alliance of Genome Resources (Release 8.3.0)

Enables metallodipeptidase activity and metalloendopeptidase activity. Involved in several processes, including germinal center formation; lymphocyte differentiation; and negative regulation of cold-induced thermogenesis. Acts upstream of or within membrane protein ectodomain proteolysis; regulation of neuron migration; and regulation of neuron projection development. Located in cytoplasm and membrane. Is active in plasma membrane. Is expressed in several structures, including brain; foregut-midgut junction; heart; lung; and retina. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in Alzheimer's disease; neonatal inflammatory skin and bowel disease 1; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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