GO Annotations Graph

• Symbol: Adam17
• Name: a disintegrin and metallopeptidase domain 17
• ID: MGI:1096335

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004175	endopeptidase activity	IDA	J:273527
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005138	interleukin-6 receptor binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0070573	metallodipeptidase activity	IMP	J:88801
Molecular Function	GO:0004222	metalloendopeptidase activity	ISO	J:164563
Molecular Function	GO:0004222	metalloendopeptidase activity	ISS	J:143685
Molecular Function	GO:0004222	metalloendopeptidase activity	TAS	Reactome:R-MMU-1168790
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:0004222	metalloendopeptidase activity	IMP	J:88801
Molecular Function	GO:0004222	metalloendopeptidase activity	ISO	J:264179
Molecular Function	GO:1902945	metalloendopeptidase activity involved in amyloid precursor protein catabolic process	ISO	J:164563
Molecular Function	GO:0008237	metallopeptidase activity	IDA	J:89492
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:164563
Molecular Function	GO:0008237	metallopeptidase activity	IMP	J:88801
Molecular Function	GO:0008237	metallopeptidase activity	IMP	J:117695
Molecular Function	GO:0008237	metallopeptidase activity	IMP	J:117695
Molecular Function	GO:0008237	metallopeptidase activity	IMP	J:88801
Molecular Function	GO:0008237	metallopeptidase activity	IMP	J:252350
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:325503
Molecular Function	GO:0008237	metallopeptidase activity	IDA	J:227692
Molecular Function	GO:0008237	metallopeptidase activity	IMP	J:227692
Molecular Function	GO:0005112	Notch binding	ISO	J:164563
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:179654
Molecular Function	GO:0005515	protein binding	IPI	J:179653
Molecular Function	GO:0005515	protein binding	IPI	J:97329
Molecular Function	GO:0004252	serine-type endopeptidase activity	TAS	Reactome:R-NUL-2484957
Molecular Function	GO:0017124	SH3 domain binding	IEA	J:60000
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0045177	apical part of cell	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:97065
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-1168790
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:227692
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-179883
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-1251988
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-2484957
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IMP	J:88801
Cellular Component	GO:0005886	plasma membrane	IMP	J:88801
Cellular Component	GO:0005886	plasma membrane	IMP	J:88801
Cellular Component	GO:0005886	plasma membrane	IMP	J:117695
Cellular Component	GO:0005886	plasma membrane	IMP	J:117695
Cellular Component	GO:0005886	plasma membrane	IMP	J:88801
Cellular Component	GO:0005886	plasma membrane	IMP	J:252350
Cellular Component	GO:0005886	plasma membrane	ISO	J:325503
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Biological Process	GO:0042987	amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:0030183	B cell differentiation	IMP	J:143629
Biological Process	GO:0007155	cell adhesion	ISO	J:164563
Biological Process	GO:0033627	cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0048870	cell motility	IMP	J:143805
Biological Process	GO:0071403	cellular response to high density lipoprotein particle stimulus	ISO	J:164563
Biological Process	GO:0050830	defense response to Gram-positive bacterium	ISO	J:164563
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0002467	germinal center formation	IMP	J:143629
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IDA	J:143685
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ISO	J:155856
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IMP	J:38527
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IDA	J:273527
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IBA	J:265628
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IDA	J:227692
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IDA	J:227692
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IMP	J:227692
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	IMP	J:249896
Biological Process	GO:0010977	negative regulation of neuron projection development	IGI	J:227692
Biological Process	GO:0010977	negative regulation of neuron projection development	IGI	J:227692
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007220	Notch receptor processing	ISO	J:164563
Biological Process	GO:0007219	Notch signaling pathway	IBA	J:265628
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	ISO	J:164563
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	IMP	J:143805
Biological Process	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0002532	production of molecular mediator involved in inflammatory response	IDA	J:219083
Biological Process	GO:0016485	protein processing	ISO	J:164563
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0035624	receptor transactivation	ISO	J:155856
Biological Process	GO:0035624	receptor transactivation	ISO	J:164563
Biological Process	GO:0048679	regulation of axon regeneration	IGI	J:227692
Biological Process	GO:0033025	regulation of mast cell apoptotic process	IMP	J:143688
Biological Process	GO:2001222	regulation of neuron migration	IGI	J:227692
Biological Process	GO:2001222	regulation of neuron migration	IGI	J:227692
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:143683
Biological Process	GO:0140448	signaling receptor ligand precursor processing	IMP	J:88801
Biological Process	GO:0140448	signaling receptor ligand precursor processing	IMP	J:88801
Biological Process	GO:0140448	signaling receptor ligand precursor processing	IMP	J:88801
Biological Process	GO:0140448	signaling receptor ligand precursor processing	IMP	J:117695
Biological Process	GO:0140448	signaling receptor ligand precursor processing	IMP	J:117695
Biological Process	GO:0140448	signaling receptor ligand precursor processing	IMP	J:88801
Biological Process	GO:0140448	signaling receptor ligand precursor processing	ISO	J:325503
Biological Process	GO:0140448	signaling receptor ligand precursor processing	IMP	J:252350
Biological Process	GO:0048536	spleen development	IMP	J:143629
Biological Process	GO:0033077	T cell differentiation in thymus	IMP	J:143629