digestive/alimentary system
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• starting at 10 weeks of age, mice present with the gross manifestations of colitis including colonic thickening and substantial increase in the size of mesenteric lymph nodes
• histological examinations reveals prominent mononuclear infiltration of epithelial tissues as well as tissue destruction of the cecum and portions of the colon
• disease is similar to what is observed in Il10tm1Cgn null mice though with less severity and incidence, and a slightly later onset
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immune system
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• starting at 10 weeks of age, mice present with the gross manifestations of colitis including colonic thickening and substantial increase in the size of mesenteric lymph nodes
• histological examinations reveals prominent mononuclear infiltration of epithelial tissues as well as tissue destruction of the cecum and portions of the colon
• disease is similar to what is observed in Il10tm1Cgn null mice though with less severity and incidence, and a slightly later onset
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• Foxp3 expressing regulatory CD4 T cells fail to produce IL-10
• mice exhibit spontaneous colitis and inflammation in the lung that is contributable to defective regulatory T cell responses
• mice also have heightened inflammatory responses when challenged with antigen to the lungs or skin
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• there is a substantial increase in ear thickness and inflammation after application of dinitrofluorobenzene (DNFB) on the ear
• T cells infiltrating the site of DNFB application have higher expression of the activation marker CD69
• there is no difference in the number of FoxP3 regulatory T cells found at the site of inflammation when compared to control mice suggesting the inability to make IL-10 is affecting regulator T cell function
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• IL-10 producing T cells are greatly diminished by the Foxp3-expressing, but not Foxp3 negative, CD4+ T cell subset
• there is almost a two-fold reduction in the number of lamina propria Foxp3 negative lymphocytes that produce IL-10
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• mice have mild perivasculitis and moderate mononuclear infiltration around large airways in the lungs
• inducing lung inflammation by sensitizing and then challenging mice with OVA peptide leads to more pronounced inflammatory response with 2.7 fold increase in leukocytes numbers from bronchoalveolar lavage fluid
• OVA induced inflammation leads to markedly increased mucus production, goblet cell expansion, edema, and increased eosinophilic infiltration around major airways
• OVA treated mice also show a marked increase in airway hyperreactivity to aerosolized methacholine
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respiratory system
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• mice have mild perivasculitis and moderate mononuclear infiltration around large airways in the lungs
• inducing lung inflammation by sensitizing and then challenging mice with OVA peptide leads to more pronounced inflammatory response with 2.7 fold increase in leukocytes numbers from bronchoalveolar lavage fluid
• OVA induced inflammation leads to markedly increased mucus production, goblet cell expansion, edema, and increased eosinophilic infiltration around major airways
• OVA treated mice also show a marked increase in airway hyperreactivity to aerosolized methacholine
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hematopoietic system
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• Foxp3 expressing regulatory CD4 T cells fail to produce IL-10
• mice exhibit spontaneous colitis and inflammation in the lung that is contributable to defective regulatory T cell responses
• mice also have heightened inflammatory responses when challenged with antigen to the lungs or skin
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Analysis Tools
